ID A0A452QRY1_URSAM Unreviewed; 212 AA.
AC A0A452QRY1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Insulin like 6 {ECO:0000313|Ensembl:ENSUAMP00000008287.1};
GN Name=INSL6 {ECO:0000313|Ensembl:ENSUAMP00000008287.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000008287.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000008287.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR AlphaFoldDB; A0A452QRY1; -.
DR STRING; 9643.ENSUAMP00000008287; -.
DR Ensembl; ENSUAMT00000009349.1; ENSUAMP00000008287.1; ENSUAMG00000007030.1.
DR GeneTree; ENSGT00940000154434; -.
DR OMA; SIACFPY; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd00101; IlGF_like; 1.
DR CDD; cd04365; IlGF_relaxin_like; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR12004:SF1; INSULIN-LIKE PEPTIDE INSL6; 1.
DR PANTHER; PTHR12004; RELAXIN; 1.
DR Pfam; PF00049; Insulin; 1.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..212
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019322051"
FT DOMAIN 30..191
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
SQ SEQUENCE 212 AA; 24649 MW; C9EC2FCAAC020F89 CRC64;
MPRLLCLCLL SLGLLLVRFS LELSEISRAR RLCGRHLLKE IVKLCGNVNW SYFEEETPMP
PLFPQDNEIE TFIPDRLESS QTTFPAWARG TNPVSTSASE EEAINSLEMS PLPEYRYIRA
NLPPDKTREF SSSQDTNQYI HEISEFQKKD TNKIKTLRNV FWGNHPQRKR RGYSEKCCLK
GCTIEELSIA CFPYVEYKNL QKQVPSFVTE IY
//
