ID   A0A452QRY6_URSAM        Unreviewed;       762 AA.
AC   A0A452QRY6;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Myotubularin related protein 10 {ECO:0000313|Ensembl:ENSUAMP00000008327.1};
GN   Name=MTMR10 {ECO:0000313|Ensembl:ENSUAMP00000008327.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000008327.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000008327.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR   AlphaFoldDB; A0A452QRY6; -.
DR   STRING; 9643.ENSUAMP00000008327; -.
DR   Ensembl; ENSUAMT00000009390.1; ENSUAMP00000008327.1; ENSUAMG00000006830.1.
DR   GeneTree; ENSGT00940000156900; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   CDD; cd14593; PTP-MTMR10; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR030573; MTMR10_PTP.
DR   InterPro; IPR022587; MTMR12-like_C.
DR   InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR   InterPro; IPR030564; Myotubularin_fam.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR   PANTHER; PTHR10807:SF39; MYOTUBULARIN-RELATED PROTEIN 10; 1.
DR   Pfam; PF12578; 3-PAP; 1.
DR   Pfam; PF06602; Myotub-related; 2.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT   DOMAIN          208..648
FT                   /note="Myotubularin phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS51339"
SQ   SEQUENCE   762 AA;  86914 MW;  1AE424598C1FF3CB CRC64;
     YRLVLKNAGS VLAFLVEPPQ TPQLFVPQFL YLTNGEIVVN EVNFVRKCIA TDTSQYDLWG
     KLICSNFKIS FITDDPMPLQ KFHYRNLLLG EHDVPLTCIE QIVTVNDHKR KQKVLGPNQK
     LKFNPTELII YCKDFRIVRF RFDESGPESA KKVCLAIAHY SQPTDLQLLF AFEYVGKKYH
     NSANKINGIP SGGGSGPGGG GVQKTPLFET YSDWDREVKR TGASGWRVCS INEGYMISTC
     LPEYFVVPSS LADQDLKIFS HSFVGRRMPL WCWSHSNGSA LVRMALIKDV LQQRKIDQRI
     CNAITKSHPQ RSDVYKSDLD KTLPNIQEIQ AAFVKLKQLC VNEPFEETEE KWLSSLENTR
     WLEYVRAFLK HSAELVYILE SRHLSVILQE EEGRDLSCIV ASLVQVMLDP HFRTITGFQS
     LIQKEWVMAG YQFLDRCNHL KRSEKESPLF LLFLDATWQL LDQYPAAFEF SETYLAVLYD
     STRISLFGTF LFNSPHQRVK QSTEFAISKN IQLGDEKGLK FPSVWDWSLQ FTAKDRTLFH
     NPLYIGKSTP CVQNGSVKSF KRTKKNYSST LRGMPASLKN GIISDQDLVP RRNSLILEAK
     PDLPQQPESQ NSGMERYFRE WFSKPADLHG VILPHLSGTH VKLWKLCYFR WVPEAQINLG
     GFITAFHKLS VLADEVDVLS RTLRQHRAGP LEACYAELDK SRMYFRASGP HDASGTPEFL
     SSSFPFSPVG NLCRRSISGT PLSKFLSGAK IWLSTETLAN ED
//