ID A0A452QS03_URSAM Unreviewed; 2990 AA.
AC A0A452QS03;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 10-FEB-2021, entry version 10.
DE SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSUAMP00000008345};
GN Name=CENPF {ECO:0000313|Ensembl:ENSUAMP00000008345};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000008345, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Ensembl:ENSUAMP00000008345, ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000008345}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
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DR Ensembl; ENSUAMT00000009412; ENSUAMP00000008345; ENSUAMG00000007040.
DR GeneTree; ENSGT00730000111187; -.
DR OMA; YNAQLVQ; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:InterPro.
DR GO; GO:0070840; F:dynein complex binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR GO; GO:0008134; F:transcription factor binding; IEA:InterPro.
DR InterPro; IPR043513; Cenp-F.
DR InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR InterPro; IPR018463; Centromere_CenpF_N.
DR PANTHER; PTHR18874; PTHR18874; 2.
DR Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 3.
DR Pfam; PF10481; CENP-F_N; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 1..302
FT /note="CENP-F_N"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 1884..2024
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2120..2259
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2302..2441
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2846..2889
FT /note="CENP-F_C_Rb_bdg"
FT /evidence="ECO:0000259|Pfam:PF10490"
FT REGION 237..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1662..1682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2792..2990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 13..131
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 159..186
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 268..372
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 381..433
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 458..482
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 504..610
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 618..638
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 646..666
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 681..708
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 720..754
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 834..861
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 894..942
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 950..991
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1024..1072
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1113..1154
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1197..1238
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1288..1315
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1392..1412
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1545..1608
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1781..1843
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1881..1901
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1923..1950
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1958..1988
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2005..2074
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2131..2193
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2201..2267
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2285..2305
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2313..2449
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2492..2592
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2600..2701
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2710..2740
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2748..2768
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 241..268
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2792..2808
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2831..2860
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2900..2956
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2990 AA; 343005 MW; 6BE65DEA497B141B CRC64;
MSWALEEWKE GLPTRALQKI QELEGQLDKL KKERQQRQFQ LETLEAALQK QKQKVENEKT
EGANLKRENQ SLMEICENLE KTKQKISHEL QVKESQVNFQ EGQLNSSKKQ IEKLEQELKR
CKSELERSQQ AAQAADVSVY SSSTPQKIFA TPLTPSSKYE DLKEKYNKEV EERKRLEAEV
KALQAKKASQ AIPQSTMNHR DIARHQASSS VFSWQQEKTP TRLSLNALKT PIRRDFSASH
FSGEQEVTPS GSTLQTGKRD ANSSFCDNSS NSHLLDQLKA QNQELRNKIS DLELHLQGQE
KEMKGQANKC QELQLQLEKA KAELIEKEKA LNKSRDELVR STAQYDQASA KCTALEQKLK
RLSEDLSCQR QNAESARCSL EQKLKEKEKE FQEELSRQQR TFQALDQECA QMKARLTQEL
QQAKNTHNIL QADLDKVTSG KYQLEKTLEE FKQKFCRAEQ ALQASQVKEN ELRRSSEEAK
KEYSLLKGQS EQRAREVCHL EEELRKAKQS LSQSQNVAEE MRAKNASQET MLRDLQEKVN
QQENSLTLDK LKLALVDLEK QRDCSQDLLK KREHHIEQLN DKLSKMEKES EALLIALELK
KKEYEELKEE KTLFARWKSE NEQLLSQLES EKGSLQSKIN HLETCLKTQQ IKSHEYNEKV
RTLEMESENL HVEIRNLHNM IDSKTVEVET QKQAYADLQQ KAEFSDQKHK KETENMCLKI
SELTGQVEDL EHKLQLLSSE VIDKDQRYQD LQAEYESLGD LLKSKDSSLV TNEAHHRSLL
AFEQQSAMNN SFVNIIGEQG STPSERSKCH LEALPSPKSS AILQNRVLSL EFSLESQKQM
NSDLQKQCEE LVQIRGEIEE NLIKAEQMHQ SFVAETSQRI SKLQEDTSVH QNAFAETLVA
LENKEREIQL LNEKLETEQA EIQELKKSNH LLQESLKALQ LLSETLSSEK KEMSSTISLN
RKEIEDLTQE NETLKEINAT LNQEKINLLQ KSESFSNCID ERDKSISELS NQYKQERLIL
QQRCEETGRA FEDLSEKYQA AQEKNSQLEC LLNECTSACE NRQKELDHLK ETFAREQEVF
VTKLALAEET NQNLVLELGA VQQDLRSEIA DIQNNSKSEA DGLKQEIMTL KEEHSKMQKE
LNALMQENEH LMMLMETKQE HQILESEAIS DSVEGESEIN KCHVQLPMDL EVKDPSLDCY
NAQLMQLEAK RRNRELKLQE SEKDKERLQH ELQTIGIELE TGNLQRDAQS QELSGPKDCD
IGTEEKYISV LHELSASQND NVLLQCSLQT AMSKLSELEK MCEMLQVEKL ELMSELNDSR
SECITTTSKM AEEMEKLVNE VKIPNDENDL LQGELVKDMV EGESDERQNE QKRASFNPLD
DSNCYEHLTL SNKEVQMHFA ELQEKFSSLQ SEHKVLYDQH RQVSSKMSEL QSYVDTLKAE
NSILSTSLRN FQGDLVKEEM LGPEEGHFLS LSFSCVTDSP SLTRLGESSF CKDLLDQTGE
TSLLNNLEGT ISANQSNIEE GSCCSPGEEK NLTRKEILSA PARSVEELET LCQMYLESLK
KLEDKIESQE IMKNKEIKEL EQLLSSEREE LDCLRKQYLS ENEQWQQKLT SVTMEMESKL
AAEKKQTEHL SFELEVARLQ LQGLDLSSRS LLGPDIEEVG NNSCDVKESE EHTLETKERT
PKHDIHQICE EGVQQDLNLE MEKVTKTSPV RFTEEWSREQ SLETPAEDKT EGCLERISDL
SFSGPNALVP MDFLETQVTI QNLQLQVKES SNEHLRLLHI IEERDKKVES LLNEIKELDS
KLHVQKAQIT AKMEACIELE KMVEELKKEK SNLSERLESF SCDKQKLHQR TESLEGLNSS
LEICADKLSH AIIEDSVAKV NDNWRERFLD VENELKRIQS EKGSIEHHAL SLEADLETVQ
TEKLYLEKDN ENQQNVIIRL EEELSVVTSE RNRLHGELDT LSKENKELDL MSEKMKQKIR
ELESHQGEGH IDVAGAEVRD QTQLIETLSS DVTKLLEENT HLQEQLQNVE KDSQALSLVK
SELEIQIEQL SREKESLARE SESLQTRLHE SEHEKLTVTK ALEGALLEKG EVAVRLSSTQ
EEVYQLRQGI EKLRVRIEAD DKKQLHVLEK LRTSERKADS LQDKVENLER ELQMSEENQE
LVILDAESSK AEVEALKTQM ELMTKSLRDL ELDLGTIRFE KENLVKQLQE KQGQVSELDT
LLSSLKGRLE EEEQEKIEMR EESKAALEML QTQLKELNEE VIALCHDQEI QKVEEQSLDP
SVQEIHQLRN SIEKLKARLE ADEKEQLQVL GKLTESEHHV DLLKDRVENL ERELERSREN
QERVILEAEN SKAEVGTLKA KIEEMAQTLR DLELDLVHIR SEKENVIKEL QKEQGRVSEL
EILNSSFENL LQEKEQEKVQ MKEESKIAVE TLQTQLKELN EKVAALCHDQ DTWKAQAQSL
RSQVDALGYE KAQLLQGLDE VKNNYLNVQS SANGLLQQVE DGKQKLEKKD EEISILKNQV
QDREQLASKL SQVEGEQQLW KKQKVELENL MVELEEKIRV LQSKNDTLQD TLEALQDSHR
DLEKELELTK MENVSFVEKV NAMTGKETEL QREMREMAQK TTELKEEYFG EKNRLTEELN
IMSQEIKSSK ADNVKYTNQL KKENERAQGK IKLLIKSCKQ LEEEKEMLQK ELSHLEAAQE
KQKTGSTVVD SNVEDLMAEI KELKETLEEK NKEADEYLDK YCSLLISHEK LEKAKEMLET
QVARLSSQSK LNLQHSPLLN SVVPEAFSAP SATEKKLSSS QSKASGKRQR STGIREDGGG
TAPSTPETFS KKSRKAVKSG IHPAEDARDT EFEPEGLPEV VKKGFADIPT GKASPYVLRR
TTMPTRTSPR LAAQKLAPSP LSLNKENHAE TSQPTAGGSR SQKVKVAQQS PADSSAPFRE
PTTRSLSVSN LPERSPANSP REGLRAKRGR LAPSPEAVPE SKSSENCRVQ
//
