ID A0A452QS30_URSAM Unreviewed; 3110 AA.
AC A0A452QS30;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 10-FEB-2021, entry version 11.
DE SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSUAMP00000008342};
GN Name=CENPF {ECO:0000313|Ensembl:ENSUAMP00000008342};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000008342, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Ensembl:ENSUAMP00000008342, ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000008342}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2019) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSUAMT00000009409; ENSUAMP00000008342; ENSUAMG00000007040.
DR GeneTree; ENSGT00730000111187; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR GO; GO:0000940; C:condensed chromosome outer kinetochore; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR InterPro; IPR043513; Cenp-F.
DR InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR InterPro; IPR018463; Centromere_CenpF_N.
DR PANTHER; PTHR18874; PTHR18874; 2.
DR Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 3.
DR Pfam; PF10481; CENP-F_N; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 1..307
FT /note="CENP-F_N"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 1892..2032
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2128..2267
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2310..2449
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2966..3009
FT /note="CENP-F_C_Rb_bdg"
FT /evidence="ECO:0000259|Pfam:PF10490"
FT REGION 242..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2912..3110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 13..131
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 164..191
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 273..377
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 386..438
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 463..487
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 509..615
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 623..643
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 651..671
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 686..713
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 725..759
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 839..866
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 899..947
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 955..996
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1029..1077
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1118..1159
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1202..1243
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1293..1320
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1397..1417
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1550..1613
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1789..1851
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1889..1909
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1931..1958
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1966..1996
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2013..2082
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2139..2201
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2209..2275
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2293..2313
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2321..2457
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2500..2600
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2608..2674
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2679..2713
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2715..2735
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2750..2822
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2830..2860
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2868..2888
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 246..273
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2912..2928
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2951..2980
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3020..3076
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3110 AA; 357239 MW; 1B0CC5F65C1B3B95 CRC64;
MSWALEEWKE GLPTRALQKI QELEGQLDKL KKERQQRQFQ LETLEAALQK QKQKVENEKT
EGANLKRENQ SLMEICENLE KTKQKISHEL QVKESQVNFQ EGQLNSSKKQ IEKLEQELKR
CKSELERSQQ AAQAADVSVY SSSTPQKIFA TPLTPSQYYS GSKYEDLKEK YNKEVEERKR
LEAEVKALQA KKASQAIPQS TMNHRDIARH QASSSVFSWQ QEKTPTRLSL NALKTPIRRD
FSASHFSGEQ EVTPSGSTLQ TGKRDANSSF CDNSSNSHLL DQLKAQNQEL RNKISDLELH
LQGQEKEMKG QANKCQELQL QLEKAKAELI EKEKALNKSR DELVRSTAQY DQASAKCTAL
EQKLKRLSED LSCQRQNAES ARCSLEQKLK EKEKEFQEEL SRQQRTFQAL DQECAQMKAR
LTQELQQAKN THNILQADLD KVTSGKYQLE KTLEEFKQKF CRAEQALQAS QVKENELRRS
SEEAKKEYSL LKGQSEQRAR EVCHLEEELR KAKQSLSQSQ NVAEEMRAKN ASQETMLRDL
QEKVNQQENS LTLDKLKLAL VDLEKQRDCS QDLLKKREHH IEQLNDKLSK MEKESEALLI
ALELKKKEYE ELKEEKTLFA RWKSENEQLL SQLESEKGSL QSKINHLETC LKTQQIKSHE
YNEKVRTLEM ESENLHVEIR NLHNMIDSKT VEVETQKQAY ADLQQKAEFS DQKHKKETEN
MCLKISELTG QVEDLEHKLQ LLSSEVIDKD QRYQDLQAEY ESLGDLLKSK DSSLVTNEAH
HRSLLAFEQQ SAMNNSFVNI IGEQGSTPSE RSKCHLEALP SPKSSAILQN RVLSLEFSLE
SQKQMNSDLQ KQCEELVQIR GEIEENLIKA EQMHQSFVAE TSQRISKLQE DTSVHQNAFA
ETLVALENKE REIQLLNEKL ETEQAEIQEL KKSNHLLQES LKALQLLSET LSSEKKEMSS
TISLNRKEIE DLTQENETLK EINATLNQEK INLLQKSESF SNCIDERDKS ISELSNQYKQ
ERLILQQRCE ETGRAFEDLS EKYQAAQEKN SQLECLLNEC TSACENRQKE LDHLKETFAR
EQEVFVTKLA LAEETNQNLV LELGAVQQDL RSEIADIQNN SKSEADGLKQ EIMTLKEEHS
KMQKELNALM QENEHLMMLM ETKQEHQILE SEAISDSVEG ESEINKCHVQ LPMDLEVKDP
SLDCYNAQLM QLEAKRRNRE LKLQESEKDK ERLQHELQTI GIELETGNLQ RDAQSQELSG
PKDCDIGTEE KYISVLHELS ASQNDNVLLQ CSLQTAMSKL SELEKMCEML QVEKLELMSE
LNDSRSECIT TTSKMAEEME KLVNEVKIPN DENDLLQGEL VKDMVEGESD ERQNEQKRAS
FNPLDDSNCY EHLTLSNKEV QMHFAELQEK FSSLQSEHKV LYDQHRQVSS KMSELQSYVD
TLKAENSILS TSLRNFQGDL VKEEMLGPEE GHFLSLSFSC VTDSPSLTRL GESSFCKDLL
DQTGETSLLN NLEGTISANQ SNIEEGSCCS PGEEKNLTRK EILSAPARSV EELETLCQMY
LESLKKLEDK IESQEIMKNK EIKELEQLLS SEREELDCLR KQYLSENEQW QQKLTSVTME
MESKLAAEKK QTEHLSFELE VARLQLQGLD LSSRSLLGPD IEEALQVGNN SCDVKESEEH
TLETKERTPK HDIHQICEEG VQQDLNLEME KVTKTSPVRF TEEWSREQSL ETPAEDKTEG
CLERISDLSF SGPNALVPMD FLETQVTIQN LQLQVKESSN EHLRLLHIIE ERDKKVESLL
NEIKELDSKL HVQKAQITAK MEACIELEKM VEELKKEKSN LSERLESFSC DKQKLHQRTE
SLEGLNSSLE ICADKLSHAI IEDSVAKVND NWRERFLDVE NELKRIQSEK GSIEHHALSL
EADLETVQTE KLYLEKDNEN QQNVIIRLEE ELSVVTSERN RLHGELDTLS KENKELDLMS
EKMKQKIREL ESHQGEGHID VAGAEVRDQT QLIETLSSDV TKLLEENTHL QEQLQNVEKD
SQALSLVKSE LEIQIEQLSR EKESLARESE SLQTRLHESE HEKLTVTKAL EGALLEKGEV
AVRLSSTQEE VYQLRQGIEK LRVRIEADDK KQLHVLEKLR TSERKADSLQ DKVENLEREL
QMSEENQELV ILDAESSKAE VEALKTQMEL MTKSLRDLEL DLGTIRFEKE NLVKQLQEKQ
GQVSELDTLL SSLKGRLEEE EQEKIEMREE SKAALEMLQT QLKELNEEVI ALCHDQEIQK
VEEQSLDPSV QEIHQLRNSI EKLKARLEAD EKEQLQVLGK LTESEHHVDL LKDRVENLER
ELERSRENQE RVILEAENSK AEVGTLKAKI EEMAQTLRDL ELDLVHIRSE KENVIKELQK
EQGRVSELEI LNSSFENLLQ EKEQEKVQMK EESKIAVETL QTQLKELNEK VAALCHDQDT
WKAQAQSLRS QVDALGYEKA QLLQGLDEVK NNYLNVQSSA NGLLQQVEDG KQKLEKKDEE
ISILKNQVQD REQLASKLSQ VEGEQQLWKK QKVELENLMV ELEEKIRVLQ SKNDTLQDTL
EALQDSHRDL EKELELTKME NVSFVEKVNA MTGKETELQR EMREMAQKTT ELKEEYFGEK
NRLTEELNIM SQEIKSSKGQ LKELMLENSE LKKNLDYIHK DQMEKEEKVQ EERAEYQLQL
QEAEKKHQAL LLDTNKQYEM EIQTYREKLS SQEECLSLQK AEVDLLKSSK EELNNSLKAT
TQILEELKKT KADNVKYTNQ LKKENERAQG KIKLLIKSCK QLEEEKEMLQ KELSHLEAAQ
EKQKTGTVVD SNVEDLMAEI KELKETLEEK NKEADEYLDK YCSLLISHEK LEKAKEMLET
QVARLSSQSK LNLQHSPLLN SVVPEAFSAP SATEKKLSSS QSKASGKRQR STGIREDGGG
TAPSTPETFS KKSRKAVKSG IHPAEDARDT EFEPEGLPEV VKKGFADIPT GKASPYVLRR
TTMPTRTSPR LAAQKLAPSP LSLNKENHAE TSQPTAGGSR SQKVKVAQQS PADSSAPFRE
PTTRSLSVSN LPERSPANSP REGLRAKRGR LAPSPEAVPE SKSSENCRVQ
//
