GenomeNet

Database: UniProt
Entry: A0A452QS30_URSAM
LinkDB: A0A452QS30_URSAM
Original site: A0A452QS30_URSAM 
ID   A0A452QS30_URSAM        Unreviewed;      3110 AA.
AC   A0A452QS30;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   10-FEB-2021, entry version 11.
DE   SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSUAMP00000008342};
GN   Name=CENPF {ECO:0000313|Ensembl:ENSUAMP00000008342};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000008342, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Ensembl:ENSUAMP00000008342, ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000008342}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2019) to UniProtKB.
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DR   Ensembl; ENSUAMT00000009409; ENSUAMP00000008342; ENSUAMG00000007040.
DR   GeneTree; ENSGT00730000111187; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR   GO; GO:0000940; C:condensed chromosome outer kinetochore; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0030496; C:midbody; IEA:Ensembl.
DR   GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR   GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR   GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR   GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR   GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR   GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR   InterPro; IPR043513; Cenp-F.
DR   InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR   InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR   InterPro; IPR018463; Centromere_CenpF_N.
DR   PANTHER; PTHR18874; PTHR18874; 2.
DR   Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR   Pfam; PF10473; CENP-F_leu_zip; 3.
DR   Pfam; PF10481; CENP-F_N; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT   DOMAIN          1..307
FT                   /note="CENP-F_N"
FT                   /evidence="ECO:0000259|Pfam:PF10481"
FT   DOMAIN          1892..2032
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2128..2267
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2310..2449
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2966..3009
FT                   /note="CENP-F_C_Rb_bdg"
FT                   /evidence="ECO:0000259|Pfam:PF10490"
FT   REGION          242..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2912..3110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          13..131
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          164..191
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          273..377
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          386..438
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          463..487
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          509..615
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          623..643
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          651..671
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          686..713
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          725..759
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          839..866
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          899..947
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          955..996
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1029..1077
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1118..1159
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1202..1243
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1293..1320
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1397..1417
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1550..1613
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1789..1851
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1889..1909
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1931..1958
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1966..1996
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2013..2082
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2139..2201
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2209..2275
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2293..2313
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2321..2457
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2500..2600
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2608..2674
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2679..2713
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2715..2735
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2750..2822
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2830..2860
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2868..2888
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        246..273
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2912..2928
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2951..2980
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3020..3076
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3110 AA;  357239 MW;  1B0CC5F65C1B3B95 CRC64;
     MSWALEEWKE GLPTRALQKI QELEGQLDKL KKERQQRQFQ LETLEAALQK QKQKVENEKT
     EGANLKRENQ SLMEICENLE KTKQKISHEL QVKESQVNFQ EGQLNSSKKQ IEKLEQELKR
     CKSELERSQQ AAQAADVSVY SSSTPQKIFA TPLTPSQYYS GSKYEDLKEK YNKEVEERKR
     LEAEVKALQA KKASQAIPQS TMNHRDIARH QASSSVFSWQ QEKTPTRLSL NALKTPIRRD
     FSASHFSGEQ EVTPSGSTLQ TGKRDANSSF CDNSSNSHLL DQLKAQNQEL RNKISDLELH
     LQGQEKEMKG QANKCQELQL QLEKAKAELI EKEKALNKSR DELVRSTAQY DQASAKCTAL
     EQKLKRLSED LSCQRQNAES ARCSLEQKLK EKEKEFQEEL SRQQRTFQAL DQECAQMKAR
     LTQELQQAKN THNILQADLD KVTSGKYQLE KTLEEFKQKF CRAEQALQAS QVKENELRRS
     SEEAKKEYSL LKGQSEQRAR EVCHLEEELR KAKQSLSQSQ NVAEEMRAKN ASQETMLRDL
     QEKVNQQENS LTLDKLKLAL VDLEKQRDCS QDLLKKREHH IEQLNDKLSK MEKESEALLI
     ALELKKKEYE ELKEEKTLFA RWKSENEQLL SQLESEKGSL QSKINHLETC LKTQQIKSHE
     YNEKVRTLEM ESENLHVEIR NLHNMIDSKT VEVETQKQAY ADLQQKAEFS DQKHKKETEN
     MCLKISELTG QVEDLEHKLQ LLSSEVIDKD QRYQDLQAEY ESLGDLLKSK DSSLVTNEAH
     HRSLLAFEQQ SAMNNSFVNI IGEQGSTPSE RSKCHLEALP SPKSSAILQN RVLSLEFSLE
     SQKQMNSDLQ KQCEELVQIR GEIEENLIKA EQMHQSFVAE TSQRISKLQE DTSVHQNAFA
     ETLVALENKE REIQLLNEKL ETEQAEIQEL KKSNHLLQES LKALQLLSET LSSEKKEMSS
     TISLNRKEIE DLTQENETLK EINATLNQEK INLLQKSESF SNCIDERDKS ISELSNQYKQ
     ERLILQQRCE ETGRAFEDLS EKYQAAQEKN SQLECLLNEC TSACENRQKE LDHLKETFAR
     EQEVFVTKLA LAEETNQNLV LELGAVQQDL RSEIADIQNN SKSEADGLKQ EIMTLKEEHS
     KMQKELNALM QENEHLMMLM ETKQEHQILE SEAISDSVEG ESEINKCHVQ LPMDLEVKDP
     SLDCYNAQLM QLEAKRRNRE LKLQESEKDK ERLQHELQTI GIELETGNLQ RDAQSQELSG
     PKDCDIGTEE KYISVLHELS ASQNDNVLLQ CSLQTAMSKL SELEKMCEML QVEKLELMSE
     LNDSRSECIT TTSKMAEEME KLVNEVKIPN DENDLLQGEL VKDMVEGESD ERQNEQKRAS
     FNPLDDSNCY EHLTLSNKEV QMHFAELQEK FSSLQSEHKV LYDQHRQVSS KMSELQSYVD
     TLKAENSILS TSLRNFQGDL VKEEMLGPEE GHFLSLSFSC VTDSPSLTRL GESSFCKDLL
     DQTGETSLLN NLEGTISANQ SNIEEGSCCS PGEEKNLTRK EILSAPARSV EELETLCQMY
     LESLKKLEDK IESQEIMKNK EIKELEQLLS SEREELDCLR KQYLSENEQW QQKLTSVTME
     MESKLAAEKK QTEHLSFELE VARLQLQGLD LSSRSLLGPD IEEALQVGNN SCDVKESEEH
     TLETKERTPK HDIHQICEEG VQQDLNLEME KVTKTSPVRF TEEWSREQSL ETPAEDKTEG
     CLERISDLSF SGPNALVPMD FLETQVTIQN LQLQVKESSN EHLRLLHIIE ERDKKVESLL
     NEIKELDSKL HVQKAQITAK MEACIELEKM VEELKKEKSN LSERLESFSC DKQKLHQRTE
     SLEGLNSSLE ICADKLSHAI IEDSVAKVND NWRERFLDVE NELKRIQSEK GSIEHHALSL
     EADLETVQTE KLYLEKDNEN QQNVIIRLEE ELSVVTSERN RLHGELDTLS KENKELDLMS
     EKMKQKIREL ESHQGEGHID VAGAEVRDQT QLIETLSSDV TKLLEENTHL QEQLQNVEKD
     SQALSLVKSE LEIQIEQLSR EKESLARESE SLQTRLHESE HEKLTVTKAL EGALLEKGEV
     AVRLSSTQEE VYQLRQGIEK LRVRIEADDK KQLHVLEKLR TSERKADSLQ DKVENLEREL
     QMSEENQELV ILDAESSKAE VEALKTQMEL MTKSLRDLEL DLGTIRFEKE NLVKQLQEKQ
     GQVSELDTLL SSLKGRLEEE EQEKIEMREE SKAALEMLQT QLKELNEEVI ALCHDQEIQK
     VEEQSLDPSV QEIHQLRNSI EKLKARLEAD EKEQLQVLGK LTESEHHVDL LKDRVENLER
     ELERSRENQE RVILEAENSK AEVGTLKAKI EEMAQTLRDL ELDLVHIRSE KENVIKELQK
     EQGRVSELEI LNSSFENLLQ EKEQEKVQMK EESKIAVETL QTQLKELNEK VAALCHDQDT
     WKAQAQSLRS QVDALGYEKA QLLQGLDEVK NNYLNVQSSA NGLLQQVEDG KQKLEKKDEE
     ISILKNQVQD REQLASKLSQ VEGEQQLWKK QKVELENLMV ELEEKIRVLQ SKNDTLQDTL
     EALQDSHRDL EKELELTKME NVSFVEKVNA MTGKETELQR EMREMAQKTT ELKEEYFGEK
     NRLTEELNIM SQEIKSSKGQ LKELMLENSE LKKNLDYIHK DQMEKEEKVQ EERAEYQLQL
     QEAEKKHQAL LLDTNKQYEM EIQTYREKLS SQEECLSLQK AEVDLLKSSK EELNNSLKAT
     TQILEELKKT KADNVKYTNQ LKKENERAQG KIKLLIKSCK QLEEEKEMLQ KELSHLEAAQ
     EKQKTGTVVD SNVEDLMAEI KELKETLEEK NKEADEYLDK YCSLLISHEK LEKAKEMLET
     QVARLSSQSK LNLQHSPLLN SVVPEAFSAP SATEKKLSSS QSKASGKRQR STGIREDGGG
     TAPSTPETFS KKSRKAVKSG IHPAEDARDT EFEPEGLPEV VKKGFADIPT GKASPYVLRR
     TTMPTRTSPR LAAQKLAPSP LSLNKENHAE TSQPTAGGSR SQKVKVAQQS PADSSAPFRE
     PTTRSLSVSN LPERSPANSP REGLRAKRGR LAPSPEAVPE SKSSENCRVQ
//
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