ID A0A452QSW6_URSAM Unreviewed; 640 AA.
AC A0A452QSW6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Solute carrier family 7 member 4 {ECO:0000313|Ensembl:ENSUAMP00000008659.1};
GN Name=SLC7A4 {ECO:0000313|Ensembl:ENSUAMP00000008659.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000008659.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000008659.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A452QSW6; -.
DR STRING; 9643.ENSUAMP00000008659; -.
DR Ensembl; ENSUAMT00000009761.1; ENSUAMP00000008659.1; ENSUAMG00000007275.1.
DR GeneTree; ENSGT00940000154637; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 2.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR029485; CAT_C.
DR PANTHER; PTHR43243:SF89; CATIONIC AMINO ACID TRANSPORTER 4; 1.
DR PANTHER; PTHR43243; INNER MEMBRANE TRANSPORTER YGJI-RELATED; 1.
DR Pfam; PF13520; AA_permease_2; 1.
DR Pfam; PF13906; AA_permease_C; 1.
DR PIRSF; PIRSF006060; AA_transporter; 2.
PE 4: Predicted;
KW Amino-acid transport {ECO:0000256|ARBA:ARBA00022970};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022970}.
FT TRANSMEM 39..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 171..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 391..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..498
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 510..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 571..588
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 540..590
FT /note="Cationic amino acid transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13906"
FT REGION 616..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..632
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 640 AA; 68986 MW; 2799F39237F844A2 CRC64;
MVRGLPSTAS LARFCQKLNR LKPLEDSTME TSLRRCLSTL DLTLLGVGGM VGSGLYVLTG
TVAKEMAGPA VLLSFAVAAV ASLLSALCYA EFGARLPRTG SAYLFTYVSM GELWAFLIGW
NVLLEYLIGG AAVARAWSGY LDSMFSHRIH NFTQAHTGTW QVPLLAHYPD FLAAGIILLA
SAFISCGARV SSWLNHTFSV VSLVLILFII ILGFILARPH NWSAEEGGFA PFGFSGIMAG
TATCFYAFVG FDVIAASSEE ARNPKQAVPI AISISLGLAA AAYILVSAVL TLMVPWHSLN
PDSALADAFY RRGYSWAGFI VAIGSICAMN TVLLSSLFSL PRIVYAMAVD GLFFQVFARV
HPRTQVPLVG IVVFGGLMSL LALLLDLEAL VQFLSIGTLL AYTFVATSIL VLRFQKAPPS
SSPGPASPGP RVKEYHSFSD HIQLVGTEQA SAPEPGQLRP ALRPYLGFLA RCSPGAAVAW
ALSILVASAI TLACVLVFGD SALHLPYWGY ILLLLFCSVA FLLSLLVLGA HQQQHQQDTF
QIPVVPLTPA LSILLNICLM LKLSYLTWLR FSIWLLIGLA VYFGYGIWHS KENQREPPEL
TTTRYVVFPS TSLEETVQTV QPASQAPAQE PSPTEQPAGP
//
