ID A0A452QU03_URSAM Unreviewed; 726 AA.
AC A0A452QU03;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=NHL repeat containing 2 {ECO:0000313|Ensembl:ENSUAMP00000009109.1};
GN Name=NHLRC2 {ECO:0000313|Ensembl:ENSUAMP00000009109.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000009109.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000009109.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A452QU03; -.
DR STRING; 9643.ENSUAMP00000009109; -.
DR Ensembl; ENSUAMT00000010254.1; ENSUAMP00000009109.1; ENSUAMG00000007615.1.
DR GeneTree; ENSGT00390000015483; -.
DR OMA; IAMAGVH; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR CDD; cd14951; NHL-2_like; 1.
DR CDD; cd03012; TlpA_like_DipZ_like; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR045302; NHL2_NHL_rpt_dom.
DR InterPro; IPR001258; NHL_repeat.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR46388; NHL REPEAT-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR46388:SF2; NHL REPEAT-CONTAINING PROTEIN 2; 1.
DR Pfam; PF01436; NHL; 4.
DR Pfam; PF13905; Thioredoxin_8; 1.
DR SMART; SM00135; LY; 2.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS51125; NHL; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 48..200
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT REPEAT 465..505
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
SQ SEQUENCE 726 AA; 79258 MW; 6BFC1AE76CE11728 CRC64;
MAVPGARGCS LAGLLPAQTS LEYALLDAVT QEEKDSLVYQ YLQKVDGWEQ DLSVPEFPEG
LEWLNTEEPI SLYKDLCGKV VILDFFTYCC INCIHLLPDL HALEHTYSAK DGLLIVGVHS
AKFPNEKVLD NIKSAVLRYN ITHPVVNDAD ASLWQELEVS CWPTLVILGP RGNMLFSLIG
EGHKDKLFLY TSIALKYYKD RGQIRDNKIE VKLYKDSLPL SPLLFPGKVT VDHVSNRLVI
ADTGHHRILV IWKNGQIQYS IGGPNPGRKD GIFSESTFNS PQGVAMRNNI IYVADTENHL
VRKIDLEAEM VSTVAGIGIQ GTDKEGGAQG EEQPISSPWD VAFGTSGSDI QREDILWIAM
AGTHQIWALL LDSGRLPKKN ELKKGTCLRF AGSGNEENRN NAYPHKAGFA QPSGLSLAPD
EPWSCLFVAD SESSTVRTVS LKDGAVKHLV GGERDPMNLF AFGDVDGVGI NAKLQHPLGV
TWDKKRNLLY VADSYNHKIK VVDPKTKNCS TLAGTGDASN AITSSFTEST FNEPGGLCIG
EDGQLLYVAD TNNHQIKVMD LETKTISVLS IFRPDSAVVD GPFPVEKPKT LPKLPKSAPN
IRLSPVAASP GQTLQFKLRL DLPSGTKLTE GVSSCWFLTA EGNEWLLQGQ IPSGEIESIS
SQPVISLQIP GDCLSLEAVI SVSVFLYYCS ADSNACMMKG IVFSQPLQIS SAHQACIAPV
ELKYGF
//
