ID A0A452QU70_URSAM Unreviewed; 2167 AA.
AC A0A452QU70;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Fibrillin 1 {ECO:0000313|Ensembl:ENSUAMP00000009184.1};
GN Name=FBN1 {ECO:0000313|Ensembl:ENSUAMP00000009184.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000009184.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000009184.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSUAMT00000010339.1; ENSUAMP00000009184.1; ENSUAMG00000001604.1.
DR GeneTree; ENSGT00950000183158; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0031012; C:extracellular matrix; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 23.
DR Gene3D; 2.10.25.10; Laminin; 36.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 7.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24039; FIBRILLIN-RELATED; 1.
DR PANTHER; PTHR24039:SF28; FIBULIN-1; 1.
DR Pfam; PF12662; cEGF; 3.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 28.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00683; TB; 7.
DR PIRSF; PIRSF036312; Fibrillin; 2.
DR SMART; SM00181; EGF; 36.
DR SMART; SM00179; EGF_CA; 36.
DR SUPFAM; SSF57196; EGF/Laminin; 11.
DR SUPFAM; SSF57184; Growth factor receptor domain; 8.
DR SUPFAM; SSF57581; TB module/8-cys domain; 7.
DR PROSITE; PS00010; ASX_HYDROXYL; 34.
DR PROSITE; PS01186; EGF_2; 22.
DR PROSITE; PS50026; EGF_3; 31.
DR PROSITE; PS01187; EGF_CA; 13.
DR PROSITE; PS51364; TB; 7.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 37..78
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 91..132
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 133..174
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 175..214
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 219..258
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 278..319
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 324..376
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 396..437
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 438..480
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 481..522
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 523..564
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 606..647
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 648..685
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 690..730
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 731..769
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 772..813
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 814..850
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 855..895
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 900..957
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 974..1015
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1016..1052
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1061..1116
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1134..1175
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1176..1216
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1217..1258
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1259..1294
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1318..1359
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1364..1416
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1432..1470
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1471..1510
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1552..1595
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1596..1637
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1642..1695
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1707..1744
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1790..1826
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1829..1871
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1872..1911
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1912..1948
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 179..189
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1263..1273
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1876..1886
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2167 AA; 236547 MW; 2D4378A8FF390004 CRC64;
CMNGRCVNTD GSYRCECFPG LAVGLDGRVC VDTHMRSTCY GGYKRGQCVK PLFGAVTKSE
CCCANTEYAF GEPCQPCPNV IDTELFSGGA DINECALDPD ICPNGICENL RGTYKCICNS
GYEVDSSGKN CVDINECVLN SLLCDNGQCR NTPGSFVCTC PKGFIYKPDL KTCEDIDECE
SSPCINGVCK NSPGSFICEC SSESTLDPTK TICIETIKGT CWQTVIDGRC EININGATLK
SQCCSSLGAA WGSPCTLCQV DPICGKGYSR IKGTQCEDIN ECEVFPGVCK NGLCVNSKGS
FKCQCPSGMT LDATGRICLD IRLETCFLRY EDEECTLPVA GRHRMDACCC SVGAAWGTEE
CEECPVRNTP EYDELCPRGP GFATKEITNG KPFFKDINEC KMIPSLCTHG KCRNTIGSFK
CRCDSGFALD SEERNCTDID ECRISPDLCG RGQCVNTPGD FECKCDEGYE SGFMMMKNCM
DIDECQRDPL LCRGGVCLNT EGSFRCECPP GHQLSPNISA CIDINECELS ANLCPHGRCV
NLIGKYQCAC NPGYHSTPDR LFCVDIDECN IMNGGCETFC TNSEGSYECS CQPGFALMPD
QRSCTDIDEC EDNPNICDGG QCTNIPGEYR CLCYDGFMAS EDMKTCVDVN ECDLNPNICL
SGTCENTKGS FICHCDMGYS GKKGKTGCTD INECEIGAHN CDRHAVCTNT AGSFKCSCSP
GWIGDGIKCT DLDECSNGTH MCSQHADCKN TMGSYRCLCK EGYTGDGFTC TDLDECSENL
NLCGNGQCLN APGGYRCECD MGFVPSADGK ACEDIDECSL PNICVFGTCH NLPGLFRCEC
EIGYELDRSG GNCTDVNECL DPTTCISGNC VNTPGSYTCD CPPDFELNPT RVGCVDTRSG
NCYLDIRPRG DNGDTACSNE IGVGVSKASC CCSLGKAWGT PCELCPPVNT SEYKILCPGG
EGFRPNPITV ILEDIDECQE LPGLCQGGKC INTFGSFQCR CPTGYYLNED TRVCDDVNEC
ETPGICGPGT CYNTVGNYTC ICPPDYMQVN GGNNCMDMRR SLCYRNYYAD NQTCDGELLF
NMTKKMCCCS YNIGRAWNKP CEQCPIPSTD EFATLCGSQR PGFVIDIYTG LPVDIDECRE
IPGVCENGVC INMVGSFRCE CPVGFFYNDK LLVCEDIDEC QNGPVCQRNA ECINTAGSFR
CDCKPGYRFT STGQCNDRNE CQEIPNICSH GQCIDTVGSF YCLCHTGFKT NADQTMCLDI
NECERDACGN GTCRNTIGSF NCRCNHGFIL SHNNDCIGAY ANRFMYFFDL IPNDKCEDID
ECVEEPEICA LGTCSNTEGS FKCLCPDGFS LSSTGRRCQD LRMSYCYAKF EGGKCSSPKS
RNHSKQECCC ALKGEGWGDP CELCPTEPDE AFRQICPYGS GIIVGPDDSA VDMDECKEPD
VCKHGQCINT DGSYRCECPF GYILEGNECV DTDECSVGNP CGNGTCKNVI GGFECTCEEG
FEPGPMMTCE DINECAQNPL LCAFRCVNTY GSYECKCPAG YVLREDRRMC KDEDECEEGK
HDCAEKQMEC KNLIGTYICI CGPGYQRRPD GEGCVDENEC QTKPGICENG RCLNTRGSYT
CECNDGFTAS PTQDECLDNR EGYCFTEVLQ NLCQIGSSNR NPVTKSECCC DGGRGWGPHC
EICPFQGTVA FKKLCPHGRG FMTNGADIDE CKVIHDVCRN GECVNDRGSY HCLCKNGYTP
DITGTSCVDL NECNQAPKPC NFICKNTEGS FQCSCPKGYI LQEDGRSCKD LDECATKQHN
CQFLCVNTIG SFTCKCPPGF TQHHTACIDN NECTSDINLC GSKGICQNTP GSFTCECQRG
FSLDQTGASC EDVDECEGNH RCQHGCQNII GGYRCSCPQG YLQHYQWNQC VDENECLSAH
ICGGASCHNT LGSYKCMCPA GFQYEQFSGG CQDINECGSA QAPCSYGCSN TEGGYLCGCP
PGYFRIGQGH CVSGIGMGRG GPEPPASGEM DDNSLSPEAC YECKINGYPK RGRKRRSANE
TDRDTNVSLA SWDIEKTAVF AFNISHISNK VRILELLPAL TTLTNHNKYL IESGNENGFF
KINQKEGISY LHFTKKKPVA GTYSLQISST PLYKQKERNQ LEDKYDKDYL SGELGDNLKM
KIQILLH
//