ID A0A452QUU2_URSAM Unreviewed; 1367 AA.
AC A0A452QUU2;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Espin {ECO:0000313|Ensembl:ENSUAMP00000009422.1};
GN Name=ESPN {ECO:0000313|Ensembl:ENSUAMP00000009422.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000009422.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000009422.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, stereocilium
CC {ECO:0000256|ARBA:ARBA00004645}.
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DR STRING; 9643.ENSUAMP00000009422; -.
DR Ensembl; ENSUAMT00000010598.1; ENSUAMP00000009422.1; ENSUAMG00000007777.1.
DR GeneTree; ENSGT00940000160408; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0032420; C:stereocilium; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR24153; ESPIN; 1.
DR PANTHER; PTHR24153:SF14; ESPIN ISOFORM X1; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF02205; WH2; 1.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM00248; ANK; 8.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 6.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS51082; WH2; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hearing {ECO:0000256|ARBA:ARBA00022740};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 69..93
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 103..127
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 171..193
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 205..227
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 239..268
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 271..303
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 650..667
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 335..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 995..1038
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1248..1332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 810..846
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 348..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..463
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..507
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..621
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..648
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..728
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1248..1265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1296..1322
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1367 AA; 147789 MW; 9EC3C868E8FF6D15 CRC64;
MALERALQAA RQGDLDVLKS LHAAGLLKPS LRDPLDALPV HHAARAGKLH CLRFLVEEAS
LPAAARARNG ATPAHDAAAT GHLSCLQWLL SQGGCGVQDK DNSGATVLHL AARFGHPEVV
DWLLRHGGGD PTVTTETGAL PVHYAAAKGD FPSLRLLMGH HPQGVNAQTK NGATPLYLAC
QEGHLEVTQY LVQECGADPH ASAQDGMTPL HAAAQMGHSS VIVWLVSCTD VSLSEQDKDG
ATAMHFAASR GHAKVLSWLL LHGGEISADL WGGTPLHDAA ENGELECCQI LVVNGAELDV
RDRDGFTAAD LSDYNGHSHC TRYLRTVENM SVEHRVLSRD PSAELETKQP DSGMSSPNTT
MSVQPLNFDL SSPTSTLSNY DSCSSSHSSI KEQRPPRRLP SSRAADIQNY MDMLSPELGR
PRGKTERTTP LPPPPSFPPP PPPPGTQLPP PPPGYPAPQP PVGPHAADIY IQTKSKLRHV
ETEAFKKELS SRDGHNGLRR QDSGRKPRAF SKQPSTGDYY RQLGRCPGEP LAAGPGMAHS
EEVRACQPAP AGRPGPGLAS RFSLASPSAP PQAALLAGNH VHNGCAADPK ASRELPPPPP
PPPPLPEALS SPPPAPPLPF EGAGPGCGQR RSSSSTGSTK SFNMMSPTGD NAELLAEIKA
GKSLKPTPQS KGLTTVFSGS GQPISQADSP LPQALPAPSR ARSPTPPAAG PQPLLNGSVA
PAPPATPAPG VQLDVEALIP THDEQGRPIP EWKRQVMVRK LQLKMQEEEE QRRKLMAASS
CCYPREGWRY SSAHNAILGP FGELMTEADI LRIEQQIENL QVLHKAQKLE ARLEQLELEL
EQLLPISAAL SAPRFTVDPR RMHGRAASLP AWCSKISTLL KSMATLLAAL GGRPAHLAEL
LAADTGQPLA PLPDAPWRPG PLCLGRSHSL SWCREAVARE ILECGVSVQH LRAVYELRAQ
GSAPAHDSCR KFSLPAGASG REPILEEDYV AAGTGESSAP AANGLRAAGD SPGAPGPPDA
PGHQAALPEP EQLARRPPLS TELRCVQDYI DMRKERIVYL FLEHWRKWTF RGPGRQAQAR
LRRLLPRVVA AGAGPVLEAA DAPQPPAGDG PDGRLLRLLR QRQVVGKLLG HWRSLLRQVP
ARPPCGSGLA HGLYWPEHFL PPFDGGAPRR YDSLTLDLFM LGYFQLLEMG LSREERKFRH
LLCYEMFDRL GSHPWELIRL FHRVVLEEVE AGRRSWSDGF EDLRRQFFGD SPEAEPSREE
EAEKEQEEEK RDEEEEREPA RKVASAQTVD CPEGQPEAPA PAPQPPTPPP PAAPPPTWDP
PSSAEAPAED PLELVSEMGE FSNEDICRYI DRSFSFWKEK EAELFDI
//
