ID A0A452QX89_URSAM Unreviewed; 1045 AA.
AC A0A452QX89;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Multiple EGF like domains 10 {ECO:0000313|Ensembl:ENSUAMP00000010417.1};
GN Name=MEGF10 {ECO:0000313|Ensembl:ENSUAMP00000010417.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000010417.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000010417.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A452QX89; -.
DR STRING; 9643.ENSUAMP00000010417; -.
DR Ensembl; ENSUAMT00000011709.1; ENSUAMP00000010417.1; ENSUAMG00000008563.1.
DR GeneTree; ENSGT00940000157703; -.
DR OMA; CPCHLPN; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0001891; C:phagocytic cup; IEA:Ensembl.
DR GO; GO:0001849; F:complement component C1q complex binding; IEA:Ensembl.
DR GO; GO:0005112; F:Notch binding; IEA:Ensembl.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:Ensembl.
DR GO; GO:0034109; P:homotypic cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0055001; P:muscle cell development; IEA:Ensembl.
DR GO; GO:0033002; P:muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0051451; P:myoblast migration; IEA:Ensembl.
DR GO; GO:0022409; P:positive regulation of cell-cell adhesion; IEA:Ensembl.
DR GO; GO:2000288; P:positive regulation of myoblast proliferation; IEA:Ensembl.
DR GO; GO:0051147; P:regulation of muscle cell differentiation; IEA:Ensembl.
DR GO; GO:0048641; P:regulation of skeletal muscle tissue development; IEA:Ensembl.
DR GO; GO:0014816; P:skeletal muscle satellite cell differentiation; IEA:Ensembl.
DR CDD; cd00055; EGF_Lam; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 4.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR24035; MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN; 1.
DR PANTHER; PTHR24035:SF109; PROTEIN DRAPER; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF12661; hEGF; 5.
DR Pfam; PF00053; Laminin_EGF; 6.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 17.
DR SMART; SM00180; EGF_Lam; 14.
DR PROSITE; PS00022; EGF_1; 16.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 9.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 762..787
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..87
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 95..130
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 138..173
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 186..216
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 224..259
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 399..434
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 485..520
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 621..651
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 659..694
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1021..1045
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 77..86
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 120..129
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 163..172
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 206..215
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 249..258
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 424..433
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 510..519
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 641..650
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 684..693
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1045 AA; 111193 MW; 5901D20E8646388A CRC64;
SCNLANWNIC RRRVTHCADK CVHGRCIAPN TCQCEPGWGG TNCSSACDGD HWGPHCSSRC
QCKNGALCNP ITGACHCAAG FRGWRCEDRC EQGTYGNDCH QRCQCQNGAT CDHVTGECRC
PPGYTGAFCE DLCPPGKHGP QCEQRCPCQN GGVCHHVTGE CSCPPGWLGT VCGQPCPEGR
FGKNCSQECQ CHNGGTCDAA TGQCHCSPGY TGERCQDECP VGTYGVRCAE TCQCINGGKC
YHVSGSCLCE AGFAGERCEA RLCPEGLYGI KCDKRCPCHL DNTHSCHPMS GECACKRGWS
GLYCNETCSP GFFGEACQQI CSCQNGADCD SVTGKCTCAP GFKGIDCSIP CPLGTYGINC
SSLCGCKNDA VCSPVDGSCT CKAGWHGVDC SISCPSGTWG FSCNLTCQCH NGGACNTQDG
TCTCAPGWRG EKCEVPCQDG TYGLNCAERC DCSHADGCHP TTGHCRCLPG WSGVHCDSVC
AEGRWGPNCS LPCYCKNGAS CSPDDGICEC APGFRGTTCQ RICSPGFYGH RCSQTCPQCV
HSSGPCHHIT GLCDCLPGFT GALCNEVCPS GRFGKNCAGV CTCTNNGTCN PIDRSCQCYP
GWIGSDCSQP CPPAHWGPNC IHTCSCHNGA FCSAYDGECK CTPGWTGLYC TQRCPLGFYG
KDCALICQCQ NGADCDHISG QCTCRTGFMG KHCEQKCPAG TYGYGCRQIC DCLNNSTCDH
ITGTCYCSPG WKGARCDQAG VIIVGNLNSL SRTSTALPAD SYQIGAIVGI IILVLVVLFL
LALFIIYRQK QKGKESSMPA VTYTPALRVM NADYAISETL PHSNGGGANS HYFTNPSYHT
LTQCATSPHV NNRDRMTIAK SKNNQLFVNL KNVNPGKRGP VTDCTGTLPA DWKHGGYLNE
LGAFGLDRSY MGKSLKDLGK NSEYNSSNCS LSSSENPYAT IKDPPVLIPK NSECGYVEMK
SPARRDSPYA EINNSTSANK NVYEVEPTVS VVQGIFSNNG HLTQDPYDLP KNSHIPCHYD
LLPVRDSSSS PKREDGGSGS SSSSE
//