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Database: UniProt
Entry: A0A452QX89_URSAM
LinkDB: A0A452QX89_URSAM
Original site: A0A452QX89_URSAM 
ID   A0A452QX89_URSAM        Unreviewed;      1045 AA.
AC   A0A452QX89;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Multiple EGF like domains 10 {ECO:0000313|Ensembl:ENSUAMP00000010417.1};
GN   Name=MEGF10 {ECO:0000313|Ensembl:ENSUAMP00000010417.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000010417.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000010417.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   AlphaFoldDB; A0A452QX89; -.
DR   STRING; 9643.ENSUAMP00000010417; -.
DR   Ensembl; ENSUAMT00000011709.1; ENSUAMP00000010417.1; ENSUAMG00000008563.1.
DR   GeneTree; ENSGT00940000157703; -.
DR   OMA; CPCHLPN; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0001891; C:phagocytic cup; IEA:Ensembl.
DR   GO; GO:0001849; F:complement component C1q complex binding; IEA:Ensembl.
DR   GO; GO:0005112; F:Notch binding; IEA:Ensembl.
DR   GO; GO:0005044; F:scavenger receptor activity; IEA:Ensembl.
DR   GO; GO:0034109; P:homotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0055001; P:muscle cell development; IEA:Ensembl.
DR   GO; GO:0033002; P:muscle cell proliferation; IEA:Ensembl.
DR   GO; GO:0051451; P:myoblast migration; IEA:Ensembl.
DR   GO; GO:0022409; P:positive regulation of cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:2000288; P:positive regulation of myoblast proliferation; IEA:Ensembl.
DR   GO; GO:0051147; P:regulation of muscle cell differentiation; IEA:Ensembl.
DR   GO; GO:0048641; P:regulation of skeletal muscle tissue development; IEA:Ensembl.
DR   GO; GO:0014816; P:skeletal muscle satellite cell differentiation; IEA:Ensembl.
DR   CDD; cd00055; EGF_Lam; 1.
DR   Gene3D; 2.10.25.10; Laminin; 2.
DR   Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 4.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR013111; EGF_extracell.
DR   InterPro; IPR002049; LE_dom.
DR   PANTHER; PTHR24035; MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN; 1.
DR   PANTHER; PTHR24035:SF109; PROTEIN DRAPER; 1.
DR   Pfam; PF07974; EGF_2; 1.
DR   Pfam; PF12661; hEGF; 5.
DR   Pfam; PF00053; Laminin_EGF; 6.
DR   PRINTS; PR00011; EGFLAMININ.
DR   SMART; SM00181; EGF; 17.
DR   SMART; SM00180; EGF_Lam; 14.
DR   PROSITE; PS00022; EGF_1; 16.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS50026; EGF_3; 9.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        762..787
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          52..87
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          95..130
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          138..173
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          186..216
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          224..259
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          399..434
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          485..520
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          621..651
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          659..694
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   REGION          1021..1045
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        77..86
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        120..129
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        163..172
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        206..215
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        249..258
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        424..433
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        510..519
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        641..650
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        684..693
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   1045 AA;  111193 MW;  5901D20E8646388A CRC64;
     SCNLANWNIC RRRVTHCADK CVHGRCIAPN TCQCEPGWGG TNCSSACDGD HWGPHCSSRC
     QCKNGALCNP ITGACHCAAG FRGWRCEDRC EQGTYGNDCH QRCQCQNGAT CDHVTGECRC
     PPGYTGAFCE DLCPPGKHGP QCEQRCPCQN GGVCHHVTGE CSCPPGWLGT VCGQPCPEGR
     FGKNCSQECQ CHNGGTCDAA TGQCHCSPGY TGERCQDECP VGTYGVRCAE TCQCINGGKC
     YHVSGSCLCE AGFAGERCEA RLCPEGLYGI KCDKRCPCHL DNTHSCHPMS GECACKRGWS
     GLYCNETCSP GFFGEACQQI CSCQNGADCD SVTGKCTCAP GFKGIDCSIP CPLGTYGINC
     SSLCGCKNDA VCSPVDGSCT CKAGWHGVDC SISCPSGTWG FSCNLTCQCH NGGACNTQDG
     TCTCAPGWRG EKCEVPCQDG TYGLNCAERC DCSHADGCHP TTGHCRCLPG WSGVHCDSVC
     AEGRWGPNCS LPCYCKNGAS CSPDDGICEC APGFRGTTCQ RICSPGFYGH RCSQTCPQCV
     HSSGPCHHIT GLCDCLPGFT GALCNEVCPS GRFGKNCAGV CTCTNNGTCN PIDRSCQCYP
     GWIGSDCSQP CPPAHWGPNC IHTCSCHNGA FCSAYDGECK CTPGWTGLYC TQRCPLGFYG
     KDCALICQCQ NGADCDHISG QCTCRTGFMG KHCEQKCPAG TYGYGCRQIC DCLNNSTCDH
     ITGTCYCSPG WKGARCDQAG VIIVGNLNSL SRTSTALPAD SYQIGAIVGI IILVLVVLFL
     LALFIIYRQK QKGKESSMPA VTYTPALRVM NADYAISETL PHSNGGGANS HYFTNPSYHT
     LTQCATSPHV NNRDRMTIAK SKNNQLFVNL KNVNPGKRGP VTDCTGTLPA DWKHGGYLNE
     LGAFGLDRSY MGKSLKDLGK NSEYNSSNCS LSSSENPYAT IKDPPVLIPK NSECGYVEMK
     SPARRDSPYA EINNSTSANK NVYEVEPTVS VVQGIFSNNG HLTQDPYDLP KNSHIPCHYD
     LLPVRDSSSS PKREDGGSGS SSSSE
//
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