ID A0A452QXA2_URSAM Unreviewed; 843 AA.
AC A0A452QXA2;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Polyserase-2 {ECO:0000256|PIRNR:PIRNR037933};
DE EC=3.4.21.- {ECO:0000256|PIRNR:PIRNR037933};
GN Name=PRSS36 {ECO:0000313|Ensembl:ENSUAMP00000010385.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000010385.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000010385.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Serine protease. Has a preference for substrates with an Arg
CC instead of a Lys residue in position P1.
CC {ECO:0000256|PIRNR:PIRNR037933}.
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DR AlphaFoldDB; A0A452QXA2; -.
DR STRING; 9643.ENSUAMP00000010385; -.
DR Ensembl; ENSUAMT00000011676.1; ENSUAMP00000010385.1; ENSUAMG00000008539.1.
DR GeneTree; ENSGT00940000161761; -.
DR OMA; QESGTWF; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 3.
DR InterPro; IPR017326; Pept_S1A_polyserase-2.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24253:SF100; POLYSERASE-2; 1.
DR PANTHER; PTHR24253; TRANSMEMBRANE PROTEASE SERINE; 1.
DR Pfam; PF00089; Trypsin; 3.
DR PIRSF; PIRSF037933; Polyserase-2; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 3.
DR PROSITE; PS50240; TRYPSIN_DOM; 3.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|PIRNR:PIRNR037933, ECO:0000256|RuleBase:RU363034};
KW Protease {ECO:0000256|PIRNR:PIRNR037933, ECO:0000256|RuleBase:RU363034};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Serine protease {ECO:0000256|RuleBase:RU363034}.
FT DOMAIN 47..291
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DOMAIN 290..543
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DOMAIN 589..796
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT REGION 21..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 87
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR037933-1"
FT ACT_SITE 139
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR037933-1"
FT ACT_SITE 243
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR037933-1"
SQ SEQUENCE 843 AA; 90649 MW; F649556641DA7AE8 CRC64;
VRLQPLPASL SPAISPIPGA FQDSGKAAGL GESHVGDCGR PEPSARIVGG SDAQPGRWPW
QVSLHQNGGH ICGGSLIAPS WVLSAAHCFV TNGTLEPATE WSVLLGVHSQ DGPLDGAHVR
AVAAVLVPDN YSSVELGADL ALLRLASPAR LGPAVRPVCL PRASHRFAPG AACWATGWGD
IQEADRLPLP WVLQEVELRL LGEATCRCLY SRPGPFNLTF QLLPGMLCAG YPEGRRDTCQ
GDSGGPLVCE EGGRWFQAGI TSFGFGCGRR NRPGVFTAVA PYEAWIREQV IGSEPGPAFP
TQSWEPQAGP WEPRDENCTV ALPECGIAPR PGAWPWEARV MVPGSRPCHG ALVSESWVLA
PASCFLDWRV LLPSRPRAEL VARLVPHENA SWDDASDLAL LQLLAPVNLS TAPRPVCLPH
PEHYFLPRSR CRLALWGRGE PAPGPNAQLE AELLSGWWCH CLYGRQGASV PPPGDPPLAL
CPAYQEEEEE AGRCWNYSHR SLLCQEEGTW FLAGISDLSS GCLRPRVFYP LQTHGPWISH
VTRGAYLEDQ LTWDWGPEGE ETETQTCPPP TEHGACGLRP EPAVMGVLWP WLVEVHVAGD
RVCTGILVAP GWVLAATHCV LRPGSTTVPY IEVYLGRAGV SPLPQGHQVS RLVIGIRLPR
HLGLRPPLAL LELSSRVEPS PSALPICLHP GGIPLGASCW VLGWKDPQDR VPVAAAVSIL
MPRLCHCLYQ GVLPPGTLCV LYLEGQEDRC EVTSAPPLLC QTEGGSWVLV GMAVRGSREL
FAAIGPEEAW ISQIVGEAHF LPPSGYPHWP PEGSDLCPPD MARASGSPQA ALFLLLLTPL
LQA
//
