ID A0A452QZU8_URSAM Unreviewed; 925 AA.
AC A0A452QZU8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Signal peptide, CUB domain and EGF like domain containing 1 {ECO:0000313|Ensembl:ENSUAMP00000011378.1};
GN Name=SCUBE1 {ECO:0000313|Ensembl:ENSUAMP00000011378.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000011378.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000011378.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A452QZU8; -.
DR Ensembl; ENSUAMT00000012796.1; ENSUAMP00000011378.1; ENSUAMG00000009250.1.
DR GeneTree; ENSGT00940000153185; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF4; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 3.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 54..94
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 263..301
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 735..847
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 267..277
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 925 AA; 101348 MW; D1D5082B15A09E01 CRC64;
MQTGPPWPLA SCPCGRVNPA WGYLRCHFPR RGLSVGLTFL LAPGHLMAGS GPADVDECSE
GTDDCHIDAI CQNTPKSYKC LCKPGYKGEG RQCEDIDECE NDYYNGGCVH ECINIPGNYR
CTCFDGFMLA HDGHNCLDVD ECQDNNGGCQ QICVNAMGSY ECQCHSGFFL SDNQHTCIHR
SNETCAVNNG GCDRTCRDTA TGVRCSCPVG FTLQPDGKTC KDINECLANN GGCDHFCRNT
VGSFECGCRK GYKLLTDERT CQDIDECSFE RTCDHICINS PGSFQCLCHR GYTLYGTTHC
GDVDECSMNN GSCDQGCINT KGSYECVCPP GRRLHWNRKD CVETGKCLSR AKAPPWAQLS
CSKVGGVESC SLSCPAHSLF VPDSDNSYSL SCGVPGLQGK MPPKRNGTGS STGPSCVPAP
IRQKARFKIR DAKCHLRPHG REPAKETLRQ LLLENCHLTS VTLKCDSSKK RRRGKKSPSK
EVTHITAEFE VETKMEEASD TCEADCMRKR AEQSLQAAIK TLRKSISRQH FSVQVAGTEY
AMAQWPAKAL EGQGACGTGQ VLQDGKCVAC GPGTYFSGDP GQCVPCAPGS YQDGDGQLSC
TPCPSSEGLG LAGARNVSEC GGQCSPGFFS PDGFRPCQAC PVGMYQPEPG RTGCFPCGGG
LLTKHEGTVS FQDCEAKVHC SPGHHYNTST HRCVRCPVGT YQPEFGQNHC ISCPGNTSTD
FDGSTNVTHC KNQHCGGELG DYTGYIESPN YPGDYPANAE CVWHISPPPK RRILIVVPEI
FLPVEDECGD VLVMRKSASP ASITTYETCQ TYERPIAFTS RSRKLWIQFK SNEGNSGKGF
QVPYVTYDED YQQLIEDIVR DGRLYASENH QEILKDKKLI KALFDVLAHP QNYFKYTAQE
SKEMFPRSFI KLLRSKVSRF LRPYK
//
