ID   A0A452R0C2_URSAM        Unreviewed;       459 AA.
AC   A0A452R0C2;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Aldehyde dehydrogenase 7 family member A1 {ECO:0000313|Ensembl:ENSUAMP00000011631.1};
GN   Name=ALDH7A1 {ECO:0000313|Ensembl:ENSUAMP00000011631.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000011631.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000011631.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986}.
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DR   STRING; 9643.ENSUAMP00000011631; -.
DR   Ensembl; ENSUAMT00000013074.1; ENSUAMP00000011631.1; ENSUAMG00000009410.1.
DR   GeneTree; ENSGT00940000154938; -.
DR   OMA; RPGHRMA; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0008802; F:betaine-aldehyde dehydrogenase activity; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR044638; ALDH7A1-like.
DR   PANTHER; PTHR43521; ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR43521:SF1; ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE; 1.
DR   Pfam; PF00171; Aldedh; 2.
DR   SUPFAM; SSF53720; ALDH-like; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT   DOMAIN          50..218
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   DOMAIN          230..415
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
SQ   SEQUENCE   459 AA;  50029 MW;  D9C8546C4EAFAB23 CRC64;
     EWLRWLVECL SSAQVIIPGF WNRAPPTSGS LLSRESASPC PSAAPPVRVI TTYCPANNEP
     IARVRQASVA DYEETVKKAK EAWRVWAEVP APKRGEVVRQ IGDALREKIQ ILGNLVSLEM
     GKILVEGVGE VQEYVDICDY AVGLSRMIGG PILPSERPGH ALIEQWNPVG LVGIITAFNF
     PVAVYGWNNA IAMICGNVCL WKGAPTTSLI SVAQVYLATL MGICLSLSAF EDADLSLVVP
     SALFAAVGTA GQRCTTARRL FLHESIHDEV VNRLKKSYAQ IRVGNPWDSS VLYGPLHTKQ
     AVSMFLGAVE EAKKEGGTVV FGGKAMDRPG NYVEPTIVTG LAHNASIAHT ETFAPILYVF
     KFKNEEEVFA WNNEVKQGLS SSIFTKDLGR IFRWLGPKGS DCGIVNVNIP TSGAEIGGXR
     FQHRYLGRRH GSGGKREGEA AFRKLDQETE ITEPSKNLV
//