ID A0A452R2A3_URSAM Unreviewed; 635 AA.
AC A0A452R2A3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=G-protein coupled receptors family 2 profile 2 domain-containing protein {ECO:0000259|PROSITE:PS50261};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000012356.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000012356.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A452R2A3; -.
DR STRING; 9643.ENSUAMP00000012356; -.
DR Ensembl; ENSUAMT00000013886.1; ENSUAMP00000012356.1; ENSUAMG00000010015.1.
DR GeneTree; ENSGT00940000155081; -.
DR OMA; NPEFNTS; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR CDD; cd15989; 7tmB2_BAI3; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011:SF40; ADHESION G PROTEIN-COUPLED RECEPTOR B3; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR01694; BAIPRECURSOR.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 87..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 83..357
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 635 AA; 70448 MW; 168605553AEB08D8 CRC64;
MFLLQGRDAG QGKKCQGLQR RVGLNEVWSG KLMNESLGTW STQGCKTVLT DASHTKCLCD
RLSTFAILAQ QPREIIMESS GTPSVTLIVG SGLSCLALIT LAVVYAALWR YIRSERSIIL
INFCLSIISS NILILVGQTQ THNKSICTTT TAFLHFFFLA SFCWVLTEAW QSYMAVTGKI
RTRLIRKRFL CLGWGLPALV VATSVGFTRT KGYGTDHYCW LSLEGGLLYA FVGPAAAVVL
VNMVIGILVF NKLVSRDGIL DKKLKHRAGQ MSEPHSGLTL KCAKCGVVST TALSATTASN
AMASLWSSCV VLPLLALTWM SAVLAMTDKR SILFQILFAV FDSLQGFVIV MVHCILRREV
QDAFRCRLRN CQDPINADSS SSFPNGHAQI MTDFEKDVDI ACRSVLHKDI GPCRAATITG
TLSRISLNDD EEEKGTNPEG LSYSTLPGNV ISKVIIQQPT GMHMPMSMNE LGNQCLKKEN
SELRRTVYLC TDDNLRGADM DMVHPQERMM ESDYIVMPRS SVNTQPSMKE ESKMNIGMET
LPHERLLHYK VNPEFNMNPP VMDQFNMNLD QHLAPQEHMQ NLPFEPRTAV KNFMASELDD
NAGLSRSETG STISMSSLEV SNRINLSLIF EIFDI
//
