ID A0A452R303_URSAM Unreviewed; 261 AA.
AC A0A452R303;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Integrin alpha third immunoglobulin-like domain-containing protein {ECO:0000259|Pfam:PF20806};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000012642.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000012642.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A452R303; -.
DR STRING; 9643.ENSUAMP00000012642; -.
DR Ensembl; ENSUAMT00000014200.1; ENSUAMP00000012642.1; ENSUAMG00000010232.1.
DR GeneTree; ENSGT00940000158443; -.
DR OMA; CMKETIN; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF78; INTEGRIN ALPHA-4; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR SUPFAM; SSF69179; Integrin domains; 1.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 204..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..185
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 261 AA; 29880 MW; C013D9A26F797D73 CRC64;
EVMLTVHGFV SPTSFVYGSK EENEPETCMA EKMNVTFHVI NTGHSMAPNV SVEIVVPNSF
APQTDKLFNI LDVQTTAGEC HFKNYQRKCA LEQEKGPMEI LKDIFKFLSK TDKKLLFCIK
ADPYCLHFFC HFGKMESGKE ASVHIQLEGR PYLSEMDESS ALKFEIRATA FPEPNPKVIE
LNKDENVAHV LLEGLHHQRP KRHFTIAIIS SSLLLGLLLL LLISYVMWKA GFFKRQYKSV
LQEENRRDSW SYVNSKSNDD D
//
