ID A0A452R3E7_URSAM Unreviewed; 457 AA.
AC A0A452R3E7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=5-hydroxytryptamine receptor 3C {ECO:0000313|Ensembl:ENSUAMP00000012803.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000012803.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000012803.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000256|RuleBase:RU000687}.
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DR AlphaFoldDB; A0A452R3E7; -.
DR STRING; 9643.ENSUAMP00000012803; -.
DR Ensembl; ENSUAMT00000014372.1; ENSUAMP00000012803.1; ENSUAMG00000010344.1.
DR GeneTree; ENSGT00940000156739; -.
DR OMA; CVGINKL; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:1904602; C:serotonin-activated cation-selective channel complex; IEA:Ensembl.
DR GO; GO:0022850; F:serotonin-gated monoatomic cation channel activity; IEA:Ensembl.
DR GO; GO:0098662; P:inorganic cation transmembrane transport; IEA:Ensembl.
DR CDD; cd19063; LGIC_TM_5-HT3; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945:SF931; 5-HYDROXYTRYPTAMINE RECEPTOR 3C; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|RuleBase:RU000687};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Signal {ECO:0000256|RuleBase:RU000687};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000687};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000687}; Transport {ECO:0000256|RuleBase:RU000687}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT CHAIN 28..457
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT /id="PRO_5022265010"
FT TRANSMEM 250..272
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 284..303
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 309..334
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 435..455
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT DOMAIN 52..248
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 255..391
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
SQ SEQUENCE 457 AA; 51301 MW; 85F74E313B803CFD CRC64;
MEGGWPVVGG VLLCLTVSLL LPGRGDTFTI NCSGFDQYGV DPAAFQAVFD RKAFRPVINN
SIPTHVNISF TLSAILEVNA QLQLLTSFLW INLMWNNPFI SWNPQECVSL KKLTVSAENL
WLPDIVILES SMDVDQAPPG LTAFVNSEGQ IKYDRPVRVT SICNLDIFYF PFDQQNCTLT
FSSFLYTVDS MLLGMDKEVW EITDTSRNLI QTQGEWELLS INKATPKMLV GSNLYDQIMF
YVAIRRRPSL YVINLLVPSG FLVAIDALSF YLPAESENRA PFKMTLLLGY NVFLLMMNDL
LPASGTPLIS VYFALCLSLM VVSLLETIFI TYLLHLATTQ PPPMPRWLHS LLLYWASPRK
CCPTAPQKGN KGLGPTPTHL PGVKEPVELV WKVSGPREAE LNGCPGSAET QQEEEAQKQH
LVDLWVKFSH VMDTLLFRLY LLFMATSVVT VIVLWNT
//
