ID   A0A452R3N0_URSAM        Unreviewed;       247 AA.
AC   A0A452R3N0;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Potassium channel tetramerization domain containing 2 {ECO:0000313|Ensembl:ENSUAMP00000012992.1};
GN   Name=KCTD2 {ECO:0000313|Ensembl:ENSUAMP00000012992.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000012992.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000012992.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
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DR   AlphaFoldDB; A0A452R3N0; -.
DR   STRING; 9643.ENSUAMP00000012992; -.
DR   Ensembl; ENSUAMT00000014580.1; ENSUAMP00000012992.1; ENSUAMG00000010485.1.
DR   GeneTree; ENSGT00940000158336; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   Gene3D; 3.30.70.2000; -; 1.
DR   Gene3D; 6.10.140.750; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   PANTHER; PTHR14958:SF22; BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD2; 1.
DR   PANTHER; PTHR14958; POTASSIUM CHANNEL TETRAMERISATION DOMAIN CONTAINING PROTEIN; 1.
DR   Pfam; PF02214; BTB_2; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; POZ domain; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT   DOMAIN          56..159
FT                   /note="BTB"
FT                   /evidence="ECO:0000259|SMART:SM00225"
FT   REGION          1..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..37
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   247 AA;  27406 MW;  A70F4C39F45F1C01 CRC64;
     GRRVTAGPVN SRGGGEMTGA QSSGGGSSYT RSLCQRTNRE PGPGPPERAG GGGAARWVRL
     NVGGTYFVTT RQTLGREPKS FLCRLCCQED PELDSDKDET GAYLIDRDPT YFGPILNYLR
     HGKLIITKEL AEEGVLEEAE FYNIASLVRL VKERIRDNEN RTSQGPVKHV YRVLQCQEEE
     LTQMVSTMSD GWKFEQLISI GSSYNYGNED QAEFLCVVSR ELNNSTNGIV IEPSEKAKIL
     QERGSRM
//