ID A0A452R438_URSAM Unreviewed; 805 AA.
AC A0A452R438;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=BCR activator of RhoGEF and GTPase {ECO:0000313|Ensembl:ENSUAMP00000013031.1};
GN Name=BCR {ECO:0000313|Ensembl:ENSUAMP00000013031.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000013031.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000013031.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendritic spine
CC {ECO:0000256|ARBA:ARBA00004552}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR AlphaFoldDB; A0A452R438; -.
DR Ensembl; ENSUAMT00000014621.1; ENSUAMP00000013031.1; ENSUAMG00000010236.1.
DR GeneTree; ENSGT00940000153491; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08686; C2_ABR; 1.
DR CDD; cd04387; RhoGAP_Bcr; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR037769; Abr/Bcr.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23182:SF3; BREAKPOINT CLUSTER REGION PROTEIN; 1.
DR PANTHER; PTHR23182; BREAKPOINT CLUSTER REGION PROTEIN BCR; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 62..254
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 446..573
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 591..782
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
SQ SEQUENCE 805 AA; 90738 MW; BDEDC1F6538C6BE4 CRC64;
VPPFCQSREV ERAAGSGAHR GAMLGCPDSR LCGDTVRPEL ALGPSWNPVV LPELDLEKGL
EMRKWVLSGI LASEETYLSH LEALLLPMKP LKAAATTSQP VLTSQQIETI FFKVPELYEI
HKEFYDGLFP RVQQWSHQQR VGDLFQKLAS QLGVYRAFVD NYGVAMETAE KCCQANTQFA
EISEVLVTLF IQVHPSTSPR WDVALLYKPV DRVTRSTLVL HDLLKHTPSS HPDHPLLQDA
LRISQNFLSS INEEITPRRQ SMTVKKGEHR QLLKDSFMVE LVEGARKLRH VFLFTDLLLC
TKLKKQSGGK TQQYDCKWYI PLTDLSFQTV DESEAAPNIP LVLDEELDAM KIKISQIKND
IQREKRANKG SKAIERLKKK LSEQESLLLL MSPSMAFRVH NRNGKVSAHY DLTQPAGASR
CFKSFSLTSV ELQMLTNSCV KLQTVHSIPL TINKEDDESP GLYGFLNVIV HSATGFKQSS
NLYCTLEVDS FGYFVNKAKT RVYRDTAEPN WNEEFEIELE GSQTLRILCY EKCYNKTKIT
KEDGESTDRI MGKGQVQLDP QALQDRDWQR TVIAMNGIEV KLSIKFTSRE FSLKRMPSRK
QTGVFGVKIA VVTKKPRSHR PAVGCAGLRQ VGYAPISALL ADNKDVSVMM SEMDVNAIAG
TLKLYFRELP EPLFTDEFYP NFAEGIALSD PVAKESCMLN LLLSLPEANL LTFLFLLDHL
KRVAEKETVN KMSLHNLATV FGPTLLRPSE KESKVPANPS QPISMTDSWS LEVMSQVQVL
LYFLQLEAIP APDSKRQSTL FSTEV
//
