ID A0A452R685_URSAM Unreviewed; 1788 AA.
AC A0A452R685;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=BTB domain containing 8 {ECO:0000313|Ensembl:ENSUAMP00000014029.1};
GN Name=BTBD8 {ECO:0000313|Ensembl:ENSUAMP00000014029.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000014029.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000014029.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 9643.ENSUAMP00000014029; -.
DR Ensembl; ENSUAMT00000015745.1; ENSUAMP00000014029.1; ENSUAMG00000011268.1.
DR GeneTree; ENSGT00940000154382; -.
DR OMA; CIPERAN; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR CDD; cd18490; BACK_BTBD8; 1.
DR CDD; cd18285; BTB1_POZ_BTBD8; 1.
DR CDD; cd18286; BTB2_POZ_BTBD8; 1.
DR InterPro; IPR043225; BACK_BTBD8.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR040121; BTBD8_BTB_POZ_1.
DR InterPro; IPR027907; BTBD8_C.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR22427:SF2; AP2-INTERACTING CLATHRIN-ENDOCYTOSIS PROTEIN; 1.
DR PANTHER; PTHR22427; UNCHARACTERIZED; 1.
DR Pfam; PF00651; BTB; 2.
DR Pfam; PF15363; BTBD8_C; 1.
DR SMART; SM00225; BTB; 2.
DR SUPFAM; SSF54695; POZ domain; 2.
DR PROSITE; PS50097; BTB; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 58..127
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT DOMAIN 206..273
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REGION 526..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 743..769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 784..956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1169..1277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1368..1397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1443..1469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1481..1526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1543..1576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..600
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..617
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..759
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..816
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..876
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 877..896
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 915..956
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1169..1188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1189..1208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1226..1254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1255..1277
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1481..1514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1562..1576
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1788 AA; 198007 MW; 101054BD4787FD97 CRC64;
MAGCGEGGAV PVVLLGSPGV CSKGLQRKGP CERRRLKAVV SEQLSQDLLR LLKEETHTDV
TFSVGSTLFK AHKAVLLARV PDFYFHTIGQ TSDNLTNHES IAVKNFEASE FRTFLQIVYS
SNRSLKNYEE EIIRKKIVER GVPHKKHDFS FEKYKKSSHC SLLKHEVPDG ISDGEDNLIS
TDNYDLDPAS ELGEDLLKLY VKHCCPDIDI YVDGKSFKAH RAILSARSSY FAAMLSGCWA
ESSQEYIILQ GINHVEMNVM MHFIYGGTLD FPDKANVGYI LNMADMYGLE GLKEVAIYIL
RRDYCNFFQK PVPRSLASVL ECLIIAHTVG VDSLFADCMK WIVKHFARFW SERSFANVPP
EIQKSCLNML IQSLNDKNAA FLLMESDRLI ISLPRVKWTE VALTMASQLQ EECIAFIIEN
FSKIIQSENF ALLLQSQAMS STADLLDKIL KAIEENITTE NSCSLFMALD MLLNSDSTKE
MGFTCKIQAL RDKLWIFLVQ SFYAVRHTES WKLMSTDDQQ KIQAAAFDKG DDRRLGKKPV
FSSSQQRRQV SDSGVIKNES WRGNTKKACW NYPSTKEKMK SDGLGASGRS SSTNRSTVNK
TLKQDDLKEK GGTKTASKVT KELKTGGKNV SGKAKAVIKP QTENSDNAKS ANTSPRQAVE
RSAAASANGQ KNSLNEKGVR NQEGHITGAR PKVLTGNLNV QTKAKPLKKV TGRDSPCLSI
AGLSSRSTNS SMELLISTEC LDEPKENGSV GEERPSGEKL SFCESPGQTV KNSVESIKTT
VAVKSRPVSK VTNGTSNKKG TQEETNINNS VLKKVTSKGY SDPVPQAILK KKGNGSGYAT
AQQRAKNASS GLVKTQGSQG ESPSSVKSSV SSRQSDENVT KLDHSTTTDK QTPKKKIVKQ
GHTPLPKVNA KIVAMPKNLN QSKKSEPLSN KDSKQKTLPG QVISKTQASS QRPLKSETCV
VQKSMLHHVH DNNNKDDISE QKRPEPLINL TSEISGREAF QWSCKPDPQK PLNNQGKEKL
VLECQSISNL DKAIKQEPES KRICSDKSET KFSSKESDHH STAKIHCLSD GSDNADPKCY
STTVLKSMIS NPSENSLNSN PVCDVDSANA EQIHSVSDKE KQGGKQDINK KLNIKCVKDV
LPCVPERTNG TLNSVQDDRK SKIHVEEQKI HSHLSDDSMS EIKHATADSD TSSKCVLEQI
SGKNSPKDME TTETPENHET PEVPFMSHWN LSTSGLHQRE SPESDTGSAT TSSDDIKPRS
EDYDAGGSQD DDGSNDRGIS KCGTMLCHDF LGRSSSDTST PEELKIYDSN LRIEVKMKKQ
SSNDLFQVNS TSDDEIPRKR PEIWPRSTVV HPREKENILR GSVQFAQEVD QVSSSADETE
DERSEAENVG ENFCTSNSAP QQFQGIINLA FEDAAENESH QFTATKNFKR SVLLSVDECE
ELGSDEGEAH TPFQPSVDSL SPSDVFDGIS HEHHGRTCYS RYTQGSEGSN LECKQNKGNS
VYKNESSLLG PSSTDSSRKD KHLSASATGK KFTVDVLSKG GRQLLPEDKK VNSGRNVDND
FQQHSKLSDN DMKSQERPCH LELHQREPNS DIPKNSSTKF LDSCRSQLLP QEGQVKENHS
TATKKANTAL SAGDIDDCDT LAQTYMYDHR PSKALSPIYE MDVIEAFEQK MESETHVTDM
DFEDDQHFAE QDWTLLKQLL SEQDSNLNIT NSVPEDLNLA QYLITQTLLL ARDSSKPQGK
AHVDTLNRWS ELTSPLDDSS ASITMASFSS EDCSPQGEWT ILELETQH
//
