ID   A0A452R7K0_URSAM        Unreviewed;      1933 AA.
AC   A0A452R7K0;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Dedicator of cytokinesis 8 {ECO:0000313|Ensembl:ENSUAMP00000014599.1};
GN   Name=DOCK8 {ECO:0000313|Ensembl:ENSUAMP00000014599.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000014599.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000014599.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00983}.
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DR   Ensembl; ENSUAMT00000016376.1; ENSUAMP00000014599.1; ENSUAMG00000008390.1.
DR   GeneTree; ENSGT00940000155876; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd08696; C2_Dock-C; 1.
DR   CDD; cd11701; DHR2_DOCK8; 1.
DR   Gene3D; 1.20.58.740; -; 1.
DR   Gene3D; 1.25.40.410; -; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR037808; C2_Dock-C.
DR   InterPro; IPR027007; C2_DOCK-type_domain.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR026791; DOCK.
DR   InterPro; IPR043161; DOCK_C_lobe_A.
DR   InterPro; IPR043162; DOCK_C_lobe_C.
DR   InterPro; IPR027357; DOCKER_dom.
DR   InterPro; IPR046769; DOCKER_Lobe_A.
DR   InterPro; IPR046770; DOCKER_Lobe_B.
DR   InterPro; IPR046773; DOCKER_Lobe_C.
DR   PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR   PANTHER; PTHR23317:SF74; DEDICATOR OF CYTOKINESIS PROTEIN 8; 1.
DR   Pfam; PF06920; DHR-2_Lobe_A; 1.
DR   Pfam; PF20422; DHR-2_Lobe_B; 1.
DR   Pfam; PF20421; DHR-2_Lobe_C; 1.
DR   Pfam; PF14429; DOCK-C2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS51650; C2_DOCK; 1.
DR   PROSITE; PS51651; DOCKER; 1.
PE   3: Inferred from homology;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT   DOMAIN          422..591
FT                   /note="C2 DOCK-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51650"
FT   DOMAIN          1466..1900
FT                   /note="DOCKER"
FT                   /evidence="ECO:0000259|PROSITE:PS51651"
SQ   SEQUENCE   1933 AA;  219925 MW;  EC174876C90C0E82 CRC64;
     NAVPLEREIF FWSHFRPTIS LLHKMGLFLQ ARPRHLNVLC DVSGKVPLTA CGFDLRSLQP
     DQRLENLLRQ VSAEDFEKQN EEARRTNRHA ELFALYPSVD EDAVEIRPVP ECPKEHLGNR
     ILVKVLTLKF EIEIEPLFAS IALYDVKERK KISENFHCDL NSDQFKGFLR AHTPSVAPSS
     QAKSAVFSVT YPSSDIYLVV KIEKVLQQGE IGDCAEPYMV IKEGDGGKSK EKIEKLKLQA
     ESFCQRLGKY RMPFAWAPIS LTSFFNVSTL EREVTDVESM VGKISTAVGR GGSVGERRTL
     SQSRRLSERA LSLEENGVGS NYKTTTMTVN SFFKQEGDRL SDEDLFKFLA DYKRSSSLQR
     RSRFPSLGLL RLEISPAPEI INCSLTPEML PVKPFPENRT RPHKEILEFP IREVYVPHTV
     YRNLLYVYPQ RLNFANKLAS ARNITIKIQF MCGEDASNAM PVIFGKSNGP EFLQEVYTAI
     TYHNKSPDFY EEVKIKLPAK LTVNHHLLFT FYHISCQQKQ GASVESLLGY SWLPILLNER
     LQTGSYCLPV ALEKLPPNYS MHSAEKVPLQ NPPIKWAEGH KGVFNIEVQA VSSVHTQDNH
     LEKFFTLCHS LESQVTFPIR VLDQKISETS LEHELKLSLI CLNSSRLEPL VLFLHLVLDK
     LFQLSVQPMV IAGQTANFSQ FAFESVVAIA NSLHNSKDLA KDQHGRNCLL ASYVHYVFRL
     PEPPRDPPKS GGAATLPDPR YHTYGRTSAA AVSSKLLQAR VMSSSNPDLA GTHCAADEEV
     KNIMSSKRRG VCVGSTCHLR LVFVLVVQHF HEELALQMVV STGMVRETVF KYAWFFFELL
     VKSMAQYVHN MDKRDNFRRT RFSDRFKDDI TTIVNVVTSE TAEKINISLA FFLYDLLSLM
     DRGFVFNLIK HYCNQVSLSA KLTNLPTLIS MRLEFLRILC SHEHYLNLNL FFMNSDTAPA
     SPCPSISSQN SSSCSSFQDQ KIASMFDLTP EYRQQHFLTG LLFTELVAAL DAEGLHPLQR
     KAVSAIHSLL SSHDLDPRCV KPEVKVKIAA LYLPLVGIIL DALPQLYDFT GNDASVGKNR
     ANGSDEDQEG TSAINQNVAL AIAGNNFTSK TSGTMLSSLP YKQYNMLNAD TTRNLMICFL
     WIMKNADQSL IKKWIADLPS MQLNRILDLL FICVSCFEYK VSARWLSLTA KSRDVKARLE
     EALLRGEGAR GEMMRRCRAP GVLALPVPAF RLNENLRWRK EQTHWRQANE KTKAELDQEA
     LISGNLATEA NLIILDMQEN IIQASSALDC KDSLLGGVLR VLVNSLSCDQ STTYLTHCFA
     TLRALIAKFG DLLFEEEVEQ CADLCQRVLH HCSSSMDVTR SQACATLYLL MRFSFGNFAR
     VKMQVTMSLA SLVGKAPDFN EEYLRRSLRT ILAYAEEDTA MQATPFPTQV EELLCNLNSI
     LYDTVKMREF QEDPEMLMDL MYRIAKSYQT SPDLRLTWLQ NMAEKHTKKK CYTEAAMCLV
     HAAALVAEYL SMLEDHSYLP VGSVSFQNIS SNVLEESAVS DDTLSPDEDG VCSGRYFTES
     GLVGLLEHAA ELFSTGGLYE TVNEVYKLVI PILEAHRDFR KLTSTHDKLQ KAFDSIISKG
     HKRMFGTYFR VGFYGSKFGD LDEQEFIYKE PAITKLPEIS HRLEGFYGQC FGEEFVEVIK
     DSAPVDKTKL DPNKAYIQIT FVEPYFDEYE MKDRVTYFEK NFNLRRFMYT TPFTLEGRPR
     GELHEQYRRN TVLTTMHAFP YIKTRISVIQ KEEFVLTPIE VAIEDMKKKT LQLAVAIHQE
     PPDAKMLQMV LQGSVGATVN QGPLEVAQVF LAEIPADPKL YRHHNKLRLC FKEFIMRCGE
     AVEKNKRLIT ADQREYQQEL KKNYHKLKEN LRPMIERKIP ELYKPIFRVE SHKRDSFHRS
     SFRKCETQLS QGS
//