ID A0A452R8B2_URSAM Unreviewed; 1052 AA.
AC A0A452R8B2;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Early endosome antigen 1 {ECO:0000313|Ensembl:ENSUAMP00000014728.1};
GN Name=EEA1 {ECO:0000313|Ensembl:ENSUAMP00000014728.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000014728.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000014728.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A452R8B2; -.
DR Ensembl; ENSUAMT00000016522.1; ENSUAMP00000014728.1; ENSUAMG00000011452.1.
DR GeneTree; ENSGT00940000156910; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15730; FYVE_EEA1; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23164; EARLY ENDOSOME ANTIGEN 1; 1.
DR PANTHER; PTHR23164:SF17; EARLY ENDOSOME ANTIGEN 1; 1.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 993..1051
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT COILED 89..766
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 813..988
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1052 AA; 121065 MW; DD3C225A7451B6A2 CRC64;
KDFICVRERE NMSGGRGKGR GRSRLPVEQG DLGLDPSDVM SVCVFLHMYY TNFSFSFLKL
HSKLLETERQ LGEAHGRLKE QRQLSSEKLM DKEQQVADLQ LKLSRLEEQL KEKVTNSTEL
QHQLDKTKQQ HQEQQALQQS TTAKLREAQN DLEQVLRQIG DKDQKIQNLE ALLQKSKENI
SLLEKEREDL YAKIQAGEGE TAVLNQLQEK NHTLQEQVTQ LTEKLKNQSE SHKQAQENLH
DQVQEQKAHL RAAQDRVLSL ETNVSELTGQ LNESKEKVSQ LDIQIKAKTE LLLSAEAAKT
AQRADLQNHL DTAQNALQDK QQELNKITTQ LDQVTTKLQD KQEHCSQLES HLKEYKEKHL
SLEQKTEELE GQIKKLEADT LEVKGSKEQA LQDLQLQRQL NTDLELRATE LSKQLEMEKE
IVSSTKLDLQ KKSEALENIK QMLTKQEEEK KILKQEIENL SQDAKMQHKE LNNKIQTAAT
ELQKVKMEKE TLMTELSATK ENLSKVSDSL KNSKSEFEKE NQKGKAAILD LEKTCKELKH
QLQVQMENTL KEQGELKKSL EKEKQTSHQL KVELNSVQGQ VVQAQNTLKQ KEKEEQQLQG
NINELKQLTE QKKKQIEALQ GEVKIAISQK TELESKLQQQ STQAAQELAA EKEKMSLLQN
TYEKSQENLK QLQSDFYGKE SELLATRQDL KSVEEKLSLA QEDLISNRNQ IGNQNKLIQE
LKTAKAALEQ ESAKKEQQLK EQCKTLQDIQ KEKSLKEKEL VNEKSKLAEI EEIKCRQEKE
IAKLSEELKS HKQESIKEVT NLKDAKQLLI QQKLELQGKV DTLKATLEQE KRNQQMLKEQ
VKKEEDELKK EFTEKEAKLQ SEIKEKEIGM KKREENEAKL TMQITALNEN LGTVKKEWQS
SQRRVSELEK QTDDLRGEIA VLEATVQNNQ DERRALLERC LKGEGEIEKL QTKVLELQRK
LDNTTAAVQE LGRENQSLQI KHTQALNRKW AEDNEVQNCM ACGKGFSVTV RRHHCRQCGN
IFCAECSAKN ALTPSSKKPV RVCDACFNDL QG
//
