ID A0A452R8V3_URSAM Unreviewed; 634 AA.
AC A0A452R8V3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Forkhead box N1 {ECO:0000313|Ensembl:ENSUAMP00000014855.1};
GN Name=FOXN1 {ECO:0000313|Ensembl:ENSUAMP00000014855.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000014855.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000014855.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR AlphaFoldDB; A0A452R8V3; -.
DR STRING; 9643.ENSUAMP00000014855; -.
DR Ensembl; ENSUAMT00000016658.1; ENSUAMP00000014855.1; ENSUAMG00000011915.1.
DR GeneTree; ENSGT00940000158029; -.
DR OMA; SHSLCEP; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0030858; P:positive regulation of epithelial cell differentiation; IEA:Ensembl.
DR CDD; cd20056; FH_FOXN1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047401; FH_FOXN1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR049624; FOXN1_4.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46721; FORKHEAD BOX PROTEIN N1; 1.
DR PANTHER; PTHR46721:SF1; FORKHEAD BOX PROTEIN N1; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 269..365
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 269..365
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 1..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 634 AA; 68045 MW; 88EE4291129E5A80 CRC64;
MVSLLPPQSD ATLPGPARLE GEPQGDLMQA PGLPGSPVPQ NKLAGFSCSS FVPDGPPERA
SSLPPQSPSV ASPGPEQVHC PAGPGPGPFR LSPSDKYPSF GFDEGPASSP GRFLKGGHGP
FHPYKRHFHE DVFPEAQTAL ALNGHSFKTP GALEAFEEIP VDVGEAEAFL PGFSAEAWCN
GLPYPSQEHS PQVLGSEVKV KPPALETGPG MYCYQPPLQH MYCPSQAPFH QYSPGGGSYP
IPYLGSSHYP YQRIAPQAST DGHQPLFPKP IYSYSILIFM ALKNSKTGSL PVSEIYNFMT
EHFPYFKTAP DGWKNSVRHN LSLNKCFEKV ENKSGSSSRK GCLWALNPAK IDKMQEELQK
WKRKDPMAVR KSMAKPEELD SLIGEKREKL GSPLLGCPAP GLASSGPIRP LAPPVGLSQP
LHSIHPAPGP IPGKNPLQDL LGGHVPSCYG QTYSHLSPGL APPGPPQPLF PQPDGHLELR
AQPGTPQDSP LPANTPPSHS AKLLAEPSPA RTMHDTLLPD GDLGTDLDAI NPSLTDFDFQ
GEMTAWPLTL GTLVDLVPNH LQCPHLPPPH GFPPGPVWQR QQWGRRLGTA RQWGLWGIGR
PALTTLYSAF MGGAHTPRPA GPSVYLAPAP GPWP
//
