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Database: UniProt
Entry: A0A452R9D9_URSAM
LinkDB: A0A452R9D9_URSAM
Original site: A0A452R9D9_URSAM 
ID   A0A452R9D9_URSAM        Unreviewed;       614 AA.
AC   A0A452R9D9;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Arachidonate 15-lipoxygenase {ECO:0000313|Ensembl:ENSUAMP00000015197.1};
GN   Name=ALOX15 {ECO:0000313|Ensembl:ENSUAMP00000015197.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000015197.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000015197.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC         Evidence={ECO:0000256|PIRSR:PIRSR601885-1};
CC       Note=Binds 1 Fe cation per subunit. {ECO:0000256|PIRSR:PIRSR601885-1};
CC   -!- SIMILARITY: Belongs to the lipoxygenase family.
CC       {ECO:0000256|RuleBase:RU003974}.
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DR   AlphaFoldDB; A0A452R9D9; -.
DR   Ensembl; ENSUAMT00000017044.1; ENSUAMP00000015197.1; ENSUAMG00000012138.1.
DR   GeneTree; ENSGT00940000162807; -.
DR   OMA; SFCPPED; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR   GO; GO:0034440; P:lipid oxidation; IEA:InterPro.
DR   Gene3D; 3.10.450.60; -; 1.
DR   InterPro; IPR000907; LipOase.
DR   InterPro; IPR013819; LipOase_C.
DR   InterPro; IPR036226; LipOase_C_sf.
DR   InterPro; IPR020834; LipOase_CS.
DR   InterPro; IPR020833; LipOase_Fe_BS.
DR   InterPro; IPR001885; LipOase_mml.
DR   PANTHER; PTHR11771; LIPOXYGENASE; 1.
DR   PANTHER; PTHR11771:SF33; POLYUNSATURATED FATTY ACID LIPOXYGENASE ALOX15; 1.
DR   Pfam; PF00305; Lipoxygenase; 1.
DR   PRINTS; PR00087; LIPOXYGENASE.
DR   PRINTS; PR00467; MAMLPOXGNASE.
DR   SUPFAM; SSF48484; Lipoxigenase; 1.
DR   PROSITE; PS00711; LIPOXYGENASE_1; 1.
DR   PROSITE; PS00081; LIPOXYGENASE_2; 1.
DR   PROSITE; PS51393; LIPOXYGENASE_3; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Dioxygenase {ECO:0000256|ARBA:ARBA00022964, ECO:0000256|RuleBase:RU003974};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR601885-1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR601885-1};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003974};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT   DOMAIN          66..614
FT                   /note="Lipoxygenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51393"
FT   REGION          36..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         312
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601885-1"
FT   BINDING         317
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601885-1"
FT   BINDING         492
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601885-1"
FT   BINDING         614
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601885-1"
SQ   SEQUENCE   614 AA;  69715 MW;  BBC3867ED0E1E1DA CRC64;
     HGFLRDPRVH RLLVCAGSHT RVQLWLVGST VRRRSGRGLR RRPGRDRERH SGEASLPVPS
     SPHLGRTVGD DPQGLFKQHR EQELEERRKL YRWGNWKDGL ILNMAGAKIS DLPVDERFLE
     DKKIDFEASL AKGLADLAIK DSLNVLTCWN DLDDFNRIFW CGQSKLAEKV RDSWKEDALF
     GYQFLNGTNP VLLRRSASLP SRLVFPPGME ELKDQLEQEL QTSTLFEADF SLLDGVKANV
     ILCSQQHLAA PLVMLKLQPD GKLLPMVIQL QLPRVGSPPP PLFLPTDPPM AWLLAKCWVR
     SADFQMHELQ SHLLRGHLMA EVITVATMRC LPSIHPIFKL IIPHLRYTLE INVRARNGLV
     SDMGIFDQVV STGGGGHVEL LQRAGAFLTY RSFCPPDDLA DRGLLGVKAS FYAQDALRLW
     EILARYVQVM VQLHYKTDEA VRDDSELQSW CREITEVGLR GAQDRGFPNS LQTRDQMCHF
     VTMCIFTCTG QHSSTHLGQL DWYSWVPNAP CTMRMPPPTT KDVTLKTLMA TLPNFHQASL
     QMSIVWQLGR RQPLMVALGQ HQEEYFSGPG PKAVLQKFRE ELTVLQKEIE TRNAKLDMPY
     EYLLPSLVEN SVAI
//
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