ID A0A452R9D9_URSAM Unreviewed; 614 AA.
AC A0A452R9D9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Arachidonate 15-lipoxygenase {ECO:0000313|Ensembl:ENSUAMP00000015197.1};
GN Name=ALOX15 {ECO:0000313|Ensembl:ENSUAMP00000015197.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000015197.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000015197.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000256|PIRSR:PIRSR601885-1};
CC Note=Binds 1 Fe cation per subunit. {ECO:0000256|PIRSR:PIRSR601885-1};
CC -!- SIMILARITY: Belongs to the lipoxygenase family.
CC {ECO:0000256|RuleBase:RU003974}.
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DR AlphaFoldDB; A0A452R9D9; -.
DR Ensembl; ENSUAMT00000017044.1; ENSUAMP00000015197.1; ENSUAMG00000012138.1.
DR GeneTree; ENSGT00940000162807; -.
DR OMA; SFCPPED; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR GO; GO:0034440; P:lipid oxidation; IEA:InterPro.
DR Gene3D; 3.10.450.60; -; 1.
DR InterPro; IPR000907; LipOase.
DR InterPro; IPR013819; LipOase_C.
DR InterPro; IPR036226; LipOase_C_sf.
DR InterPro; IPR020834; LipOase_CS.
DR InterPro; IPR020833; LipOase_Fe_BS.
DR InterPro; IPR001885; LipOase_mml.
DR PANTHER; PTHR11771; LIPOXYGENASE; 1.
DR PANTHER; PTHR11771:SF33; POLYUNSATURATED FATTY ACID LIPOXYGENASE ALOX15; 1.
DR Pfam; PF00305; Lipoxygenase; 1.
DR PRINTS; PR00087; LIPOXYGENASE.
DR PRINTS; PR00467; MAMLPOXGNASE.
DR SUPFAM; SSF48484; Lipoxigenase; 1.
DR PROSITE; PS00711; LIPOXYGENASE_1; 1.
DR PROSITE; PS00081; LIPOXYGENASE_2; 1.
DR PROSITE; PS51393; LIPOXYGENASE_3; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964, ECO:0000256|RuleBase:RU003974};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR601885-1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR601885-1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003974};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 66..614
FT /note="Lipoxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51393"
FT REGION 36..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 312
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR601885-1"
FT BINDING 317
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR601885-1"
FT BINDING 492
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR601885-1"
FT BINDING 614
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR601885-1"
SQ SEQUENCE 614 AA; 69715 MW; BBC3867ED0E1E1DA CRC64;
HGFLRDPRVH RLLVCAGSHT RVQLWLVGST VRRRSGRGLR RRPGRDRERH SGEASLPVPS
SPHLGRTVGD DPQGLFKQHR EQELEERRKL YRWGNWKDGL ILNMAGAKIS DLPVDERFLE
DKKIDFEASL AKGLADLAIK DSLNVLTCWN DLDDFNRIFW CGQSKLAEKV RDSWKEDALF
GYQFLNGTNP VLLRRSASLP SRLVFPPGME ELKDQLEQEL QTSTLFEADF SLLDGVKANV
ILCSQQHLAA PLVMLKLQPD GKLLPMVIQL QLPRVGSPPP PLFLPTDPPM AWLLAKCWVR
SADFQMHELQ SHLLRGHLMA EVITVATMRC LPSIHPIFKL IIPHLRYTLE INVRARNGLV
SDMGIFDQVV STGGGGHVEL LQRAGAFLTY RSFCPPDDLA DRGLLGVKAS FYAQDALRLW
EILARYVQVM VQLHYKTDEA VRDDSELQSW CREITEVGLR GAQDRGFPNS LQTRDQMCHF
VTMCIFTCTG QHSSTHLGQL DWYSWVPNAP CTMRMPPPTT KDVTLKTLMA TLPNFHQASL
QMSIVWQLGR RQPLMVALGQ HQEEYFSGPG PKAVLQKFRE ELTVLQKEIE TRNAKLDMPY
EYLLPSLVEN SVAI
//