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Database: UniProt
Entry: A0A452R9H1_URSAM
LinkDB: A0A452R9H1_URSAM
Original site: A0A452R9H1_URSAM 
ID   A0A452R9H1_URSAM        Unreviewed;       639 AA.
AC   A0A452R9H1;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
GN   Name=SLCO2A1 {ECO:0000313|Ensembl:ENSUAMP00000015233.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000015233.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000015233.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC       {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU362056}.
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DR   AlphaFoldDB; A0A452R9H1; -.
DR   Ensembl; ENSUAMT00000017081.1; ENSUAMP00000015233.1; ENSUAMG00000011345.1.
DR   GeneTree; ENSGT01080000257336; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR   CDD; cd17461; MFS_SLCO2A_OATP2A; 1.
DR   Gene3D; 3.30.60.30; -; 1.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR004156; OATP.
DR   NCBIfam; TIGR00805; oat; 1.
DR   PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR   PANTHER; PTHR11388:SF14; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 2A1; 1.
DR   Pfam; PF07648; Kazal_2; 1.
DR   Pfam; PF03137; OATP; 1.
DR   SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR   PROSITE; PS51465; KAZAL_2; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Ion transport {ECO:0000256|RuleBase:RU362056};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362056};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT   TRANSMEM        67..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362056"
FT   TRANSMEM        95..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362056"
FT   TRANSMEM        165..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362056"
FT   TRANSMEM        201..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362056"
FT   TRANSMEM        249..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362056"
FT   TRANSMEM        322..344
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362056"
FT   TRANSMEM        356..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362056"
FT   TRANSMEM        394..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362056"
FT   TRANSMEM        509..533
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362056"
FT   TRANSMEM        545..563
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362056"
FT   TRANSMEM        601..619
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362056"
FT   DOMAIN          1..624
FT                   /note="Major facilitator superfamily (MFS) profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50850"
FT   DOMAIN          433..491
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51465"
SQ   SEQUENCE   639 AA;  70386 MW;  064E42AB9D17CB58 CRC64;
     DGVLPLPPHV QASFWSEEQG GRRLRKEVFV LCHGLLQLCQ LLYSAYFKSS LTTIEKRFGL
     SSSSSGLISS LNEISNAILI IFVSYFGSRV HRPRLIGIGG LLLASGAFVL TLPHFLSEPY
     QYTVASVGNS SHFQAELCQK HWKDLPPSKC HSTTQDSRKE TSSMWGLMVV AQLLAGVGTV
     PIQPFGISYV DDFSEPNNSP LYISILFAIS VFGPAFGYLL GSVMLQIFVD YGRVDTAAVN
     LTPRDPRWIG AWWLGLLISS ASLVLTSFPF FFFPRTMLRE TERSPAIVDE ARKMDEVKTR
     SSLVDFIKRF PRIFLRLLMN PLFMLVVLAQ CTFSSVIAGL STFLNKFLEK QYGASAAYAN
     FLIGAVNLPA AALGMLFGGI LMKRFVFSLQ TIPRVAATII TISMVLCAPL FFMGCSTPTV
     AEVYPPRTSS SIHLQPLACR RHCSCPDAIF HPVCGDNGVE YLSPCHAGCS NVNFSSMASK
     QLTYLNCSCV TGASSSAKTG SCPIPCAHFL LPAIFLISFV ALIACISHNP LYMMVLRVVN
     QEEKSFAIGV QFLLMRLLAW LPSPALYGLT IDYSCIRWGS QCSGRRGACA YYDNDALRDR
     YLGLQVGYKA LGALLLLFIS WRVKKSKEYN VQEKAAGLI
//
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