ID A0A452RA50_URSAM Unreviewed; 1208 AA.
AC A0A452RA50;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=ATPase 13A3 {ECO:0000313|Ensembl:ENSUAMP00000015509.1};
GN Name=ATP13A3 {ECO:0000313|Ensembl:ENSUAMP00000015509.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000015509.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000015509.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type V subfamily. {ECO:0000256|ARBA:ARBA00006000}.
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DR AlphaFoldDB; A0A452RA50; -.
DR Ensembl; ENSUAMT00000017381.1; ENSUAMP00000015509.1; ENSUAMG00000011019.1.
DR GeneTree; ENSGT00940000155941; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015662; F:P-type ion transporter activity; IEA:InterPro.
DR CDD; cd07542; P-type_ATPase_cation; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006544; P-type_TPase_V.
DR InterPro; IPR047819; P5A-ATPase_N.
DR InterPro; IPR047821; P5B-type_ATPase.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR NCBIfam; TIGR01657; P-ATPase-V; 1.
DR PANTHER; PTHR45630; CATION-TRANSPORTING ATPASE-RELATED; 1.
DR PANTHER; PTHR45630:SF12; POLYAMINE-TRANSPORTING ATPASE 13A3; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00690; Cation_ATPase_N; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF12409; P5-ATPase; 1.
DR PRINTS; PR00119; CATATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 432..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 918..942
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 948..971
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 983..1010
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1056..1074
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1086..1110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1122..1142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 13..104
FT /note="P5B-type ATPase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12409"
FT DOMAIN 158..208
FT /note="Cation-transporting P-type ATPase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00690"
SQ SEQUENCE 1208 AA; 136015 MW; 0D0963532F69A7DC CRC64;
MDKEERKTIN QGQEDEMEIY GYNLCRWKLA VVSLGVVCTG GFLLLLLYWM PEWRVKATCI
RAAIRDCEVV LLRTTDEFRM WFCAKIRFLS LETHPFLSPK SMTNKVANGH AVHLSENLAE
ETRHEMSKYS QTQPQQEYRK MRGLDEGVSC TSIYEKHSAG LTKGMHAYRK LLYGVNEITV
KVPSVFKLLI KEVLNPFYIF QLFSVILWST DEYYYYALAI VIMSIVSIVS SLYSIRKQYI
MLHDMVAAHS TVRVSVCRVN EEIEEIFSTD LVPGDVMVIP LNGTVMPCDA VLINGTCIVN
ESMLTGESVP VTKTNLPNPS VDIKGMGDEF YSPEIHKRHT LFCGTTVIQT RFYTGELVKA
VVVRTGFSTS KGQLVRSILY PKPTDFKLYR DAYLFLLCLV AVAGIGFIYT IINSILNKVE
IGVIIIESLD IITITVPPAL PAAMTAGIVY AQRRLKKIGI FCISPQRINI CGQLNLVCFD
KTGTLTEDGL DLWGIQRVEN TRFLLPEENV CNEILVKSQF VACMATCHSL TKIEGVLSGD
PLDLKMFEAI GWILEEATEE ETALHNRIMP TVVRPAKQLL PESTPAGNQE MELFELPAIY
EIGIVRQFPF SSALQRMSVV ARVLGDKKMD AYMKGAPEVI ASLCKPETVP VDFEKVLEDY
TKQGFRVIAL AHRKLESKLT WHKVQNISRD VIENNMDFMG LIVMQNKLKQ ETPAVLEDLH
KANIRTVMVT GDNMLTAVSV ARDCGMILPQ DKVIIAEALP PKDGKVAKIN WHYADTLTQC
SNSSAIDSEA IPIKLVHDSL EDLQVTRYHF AMNGKSFSVI LEHFQDLAPK LMLHGTVFAR
MAPDQKTQLI EALQNVDYFV GMCGDGANDC GALKRAHGGI SLSELEASVA SPFTSKTPSI
SCVPNLIREG RAALMTSFCV FKFMALYSII QYFSVTLLYS ILSNLGDFQF LFIDLAIILV
VVFTMSLNPA WKELVAQRPP SGLISGALLF SVLSQIIICI GFQSLGFFWV KQQPWYEVWH
PQSDACNTTG SLYWNSSHLY NETDLDTHNI QNYENTTVFF ISSFQYLIVA IAFSKGKPFR
QPCYKNYFFV VSVIILYVFI LLIMLHPVAS IDQVLQIVCV PYQWRITMLM IVLVNALVSI
MVEESVDRWG KCCLSWALGC RKKIPKAKYM YLAQELLVDP EWPPKPQTTT EAKALVKENG
SCQIITIT
//
