ID A0A452RAC6_URSAM Unreviewed; 1128 AA.
AC A0A452RAC6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Large proline-rich protein BAG6 {ECO:0000256|ARBA:ARBA00021614};
DE AltName: Full=BCL2-associated athanogene 6 {ECO:0000256|ARBA:ARBA00030033};
DE AltName: Full=HLA-B-associated transcript 3 {ECO:0000256|ARBA:ARBA00029739};
GN Name=BAG6 {ECO:0000313|Ensembl:ENSUAMP00000015571.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000015571.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000015571.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Released extracellularly via exosomes, it is a ligand of the
CC natural killer/NK cells receptor NCR3 and stimulates NK cells
CC cytotoxicity. It may thereby trigger NK cells cytotoxicity against
CC neighboring tumor cells and immature myeloid dendritic cells (DC).
CC {ECO:0000256|ARBA:ARBA00002067}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC Secreted, extracellular exosome {ECO:0000256|ARBA:ARBA00004550}.
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DR AlphaFoldDB; A0A452RAC6; -.
DR Ensembl; ENSUAMT00000017452.1; ENSUAMP00000015571.1; ENSUAMG00000012447.1.
DR GeneTree; ENSGT00390000016199; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR CDD; cd01809; Ubl_BAG6; 1.
DR InterPro; IPR021925; BAG6.
DR InterPro; IPR048926; Bag6_BAGS.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR019954; Ubiquitin_CS.
DR PANTHER; PTHR15204; LARGE PROLINE-RICH PROTEIN BAG6; 1.
DR PANTHER; PTHR15204:SF0; LARGE PROLINE-RICH PROTEIN BAG6; 1.
DR Pfam; PF12057; BAG6; 1.
DR Pfam; PF20960; Bag6_BAGS; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00299; UBIQUITIN_1; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Spermatogenesis {ECO:0000256|ARBA:ARBA00022871}.
FT DOMAIN 19..79
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
FT REGION 90..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 383..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 939..1128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..265
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..583
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..679
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 957..971
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1128 AA; 118789 MW; E3EB1A408954BC2E CRC64;
MEPGDSTSTT TSMEEPDSLE VLVKTLDSQT RTFIVGAQMN VKEFKEHIAA SVSIPSEKQR
LIYQGRVLQD DKKLQEYNVG GKVIHLVERA PPQTQLPSGA PSGIGSASAT HGGGPPPGTR
GPGTSVHDRN ANSYVMVGTF NLPSDGSAVD VHINMEQAPI QSEPRVRLVM AQHMIRDIQT
LLSRMECRGG PQAQHSQPPP QTPTMAPEPA ALSSPTSEAV ESEVPPREPM EAEEVEERAP
AQSPELTPSG PAPVGPAPAP ETNAPNHPSP AEYVEVLQEL QRLESRLQPF LQRYYEVLGA
AATTDYNNNQ EGREEDQRLI NLVGESLRLL GNTFVALSDL RCNLACAPPR HLHVVRPMSH
YTTPMVLQQA AIPIQINVGT TVTMTGNGTR PPPAANAEAA PPGPGQASSL APTSATVESS
TEGVPPPGPA PPPTTSHPRV IRISHQSVEP VVMMHMNIQD SGTQPGGVPS APTGPLGPPG
HGQTLGQQVP GFPTAPTRVV IARPTPPQAR PSHPGGPPVS GTLQGAGLGT NASLAQMVSG
LVGQLLMQPV LVAQGTPGMA PPPAPATASA SAGTTNTATT AGPAPGGPAQ PPPPQPSAAD
LQFSQLLGNL LGPAGPGAGG PGMASPTITV AMPGVPAFLQ GMTDFLQATQ TAPPPPPPPP
PPPPAPEQQT MPPPGSPSGG AGSPGGLGLE SLSPEFFTSV VQGVLNSLLG SLGARAGSSE
SIAAFIQRLS GSSNIFEPGA DGALGFFGAL LSLLCQNFSM VDVVMLLHGH FQPLQRLQPQ
LRSFFHQHYL GGQEPTPGNI RTATHTLITG LEEYVRESFS LVQVQPGVDI IRTNLEFLQE
QFNSIAAHVL HCTDSGFGAR LLELCNQGLF ECLALNLHCL GGQQMELAAV INGRIRRMSR
GVNPSLVSWL TTMMGLRLQV VLEHMPVGPD AILRYVRRVG DPPQPLPEEP MEVQGSERTS
PEPQRENASP APGTTAEEAM SRGPPPPEGG GSREEQDGAS AETEPWAAAV PPEWVPIIQQ
DIQSQRKVKP QPPLSDAYLS GMPAKRRKTM QGEGPQLLLS EAVSRAAKAA GARPLTSPES
LSRDLEAPEV QESYRQQLRA DIQKRLQEDP NYSPQRFPNA HRAFADDP
//