ID A0A452RC04_URSAM Unreviewed; 2117 AA.
AC A0A452RC04;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Dedicator of cytokinesis 9 {ECO:0000313|Ensembl:ENSUAMP00000016201.1};
GN Name=DOCK9 {ECO:0000313|Ensembl:ENSUAMP00000016201.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000016201.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000016201.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR STRING; 9643.ENSUAMP00000016201; -.
DR Ensembl; ENSUAMT00000018151.1; ENSUAMP00000016201.1; ENSUAMG00000010670.1.
DR GeneTree; ENSGT00940000155972; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11698; DHR2_DOCK9; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF77; DEDICATOR OF CYTOKINESIS PROTEIN 9; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 171..278
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 637..815
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1626..2079
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 287..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1239..1281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..303
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2117 AA; 241825 MW; 005C46F7387E6111 CRC64;
MQADKCRTSS RSVKKELVIE SPLRRKDAAQ GEVEAEGPGP AKPKLIEPLD YENVIVQKKT
QILNDCLREM LLFPYDDFQT ATLRRQGRYM CSTVPADAQE EAQSLFVTEC IKTYNSDWHL
VNYKFEDYSG EFRQLPNKVA KLDKLPVHVY EVDEEVDKDE DAASLGSQKG GITKHGWLYK
GNVNSAISVT MRSFKRRFFH LLQLGDGSYN LNFYKDEKIS KEPKGSIFLD SCMGVVQNNK
VRRFAFELKM QDKSSYLLAA DSEAEMEEWI TILNKILQLN FEAAMQEKRN GDSHEDDEQS
KLEGSGSGLD SYLPELAKST REAEMKLKSE SRVKLFYLDP DAQKLDFTSA EPEVKPFEEK
FGKRILVKCN DLSFNLQCCV AENEEGPTTN VEPFFVTLSL FDIKYNRKIS ADFHVDLNHF
SVRQMLATTS PALMNGGRQS APALQDILHE AAMQYPKQGI FSVTCPHPDI FLVARIEKVL
QGSITHGAEP YMKSSDSSKV AQKVLKNAKQ ACQRLGQYRM PFAWAARTLF KDASGNLDKN
ARFSALYRQD SNKLSNDDML KFLADFRKPE KMAKLPVILG NLDITIDNVS SDFPNYVNSS
YIPMKQFETC SKTPITFEVE EFVPCIPRHT QPYTIYNNHL YVYPKYLKYD SQKSFAKARN
IAICIEFKDS DEEDSQPLKC IYGRPGGPVF TRSAFAAVLH HHQNPEFYDE IKIELPTQLH
EKHHLLFTFF HVSCDNSSKG STKKKDVVET QVGYSWLPLL KDGRVVTSEQ HVPVSANLPS
GYLGYQELGM GRHYGPEIKW VDGSKPLLKV STHLVSTVYT QDQHLHNFFQ YCQKTESGAQ
ALGSELVKYL KSLHAMEGHV MIAFLPTILN QLFRVLTRAT QEEVAVNVTR VIIHVVAQCH
EEGLESHLRS YVKYAYKAEP YIASEYKTVH EELTKAMTTI LKPSADFLTS NKLLKYSWFF
FDVLIKSMAQ HLIENSKVKL LRNQRFPASY HHAVETVVTM LMPHITQKFR DNPEASKNAN
HSLAVFIKRC FTFMDRGFVF KQINNYISCF APGDPKTLFE YKFEFLRVVC NHEHYIPLNL
PMPFGKGRIQ RYQDLQLDYS LTDEFCRNHF LVGLLLREVG TALQEFREVR LIAISVLKNL
LIKHSFDDRY ASRSHQARIA TLYLPLFGLL IENVQRINVR DVSPFPVNPG STMKEESLPL
PAANPLVTPQ KPGIALDNSL HKDLFGAISG IASPYTTSTP NINSVRNADS RGSLISTDSG
NSLPERNSEK SNSLDKHQQS GTLGNSVVRC DKLDQSEIKS LLMCFLYILK SMSDDALFTY
WNKASTAELM DFFTISEVCL HQFQYMGKRY IARTQEGLGP IVHDRKSQTL PVSRNRTGMM
HARLQQLGSL DNSLTFNHSY GHSDADVLHQ SLLEANIATE VCLTALDTLS LFTLAFKNQL
LADHGHNPLM KKVFDVYLCF LQKHQSETAL KNVFTALRSF IYKFPSTFYE GRADMCAALC
YEILKCCNSK LSSIRTEASQ LLYFLMRNNF DYTGKKSFVR THLQVIISVS QLIADVVGIG
GTRFQQSLSI INNCANSDRL IKHTTFSSDV KDLTKRIRTV LMATAQMKEH ENDPEMLVDL
QYSLAKSYAS TPELRKTWLD SMARIHVKNG DLSEAAMCYV HVTALVAEYL TRKEADIVLR
PEPPLFPSSH STCQRRRRGG MFRQGCTAFR VITPNIDEEA SMMEDVGMQD VHFNEDVLME
LLEQCADGLW KAERYELIAD IYKLIIPIYE KRRDFERLAH LYDTLHRAYS KVTEVMHSGR
RLLGTYFRVA FFGQGFFEDE DGKEYIYKEP KLTPLSEISQ RLLKLYSDKF GSENVKMIQD
SGKVNPKDLD SKYAYIQVTH VIPFFDEKEL QERKTEFERS HNIRRFMFEM PFTQTGKRQG
GVEEQCKRRT ILTAIHCFPY VKKRIPVMYQ HHTDLNPIEV AIDEMSKKVA ELRQLCSSAE
VDMIKLQLKL QGSVSVQVNA GPLAYARAFL DDTNTKRYPD NKVKLLKEVF RQFVEACGQA
LAVNERLIKE DQLEYQEEMK ANYREMAKEL SEIMHEQICP LEEKTSVLPN SLHIFNAISG
TPTSTMVHGM TSSSSVV
//
