ID A0A452RCL0_URSAM Unreviewed; 1891 AA.
AC A0A452RCL0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRS {ECO:0000313|Ensembl:ENSUAMP00000016421.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000016421.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000016421.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR Ensembl; ENSUAMT00000018390.1; ENSUAMP00000016421.1; ENSUAMG00000012727.1.
DR GeneTree; ENSGT00940000153617; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 8.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR CDD; cd14627; R-PTP-S-2; 1.
DR CDD; cd14625; R-PTPc-S-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF8; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S; 1.
DR Pfam; PF00041; fn3; 6.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 7.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 7.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1246..1269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..111
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 123..218
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 231..299
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 306..396
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 401..495
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 594..692
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 697..805
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 806..903
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 904..1006
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1009..1100
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1336..1591
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1511..1582
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1623..1882
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1800..1873
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1891 AA; 210802 MW; B75A2EFE5E19F22B CRC64;
HFPEPVPSGT LPLPSLSPEP PRFIKEPKDQ IGVSGGVASF VCQATGDPKP RVTWNKKGKK
VNSQRFETIE FDQSAGAVLR IQPLRTPRDE NVYECVAQNS AGEVTVHAKL TVLREDQLPP
GFPNIDMGPQ LKVVERTRTA TMLCAASGNP DPEITWFKDF LPVDPSASNG RIKQLRSGDT
PIRGALQIES SEETDQGKYE CVATNSAGVR YSSPANLYVR GRERRIQIMP GGNVNITCVA
VGSPMPYVKW MQGAEDLTPE DDMPVGRNVL ELTDVKDSAN YTCVAMSSLG VIEAVAQITV
KSLPKAPGTP VVTENTATSI TITWDSGNPD PVSYYVIEYK SKSQDGPYQI KEDITTTRYS
IGGLSPNSEY EIWVSAVNSI GQGPPSESVV TRTGEQAPAS APRNVQARML SATTMIVQWE
EPVEPNGLIR GYRVYYTMEP EHPVGNWQKH NVDDSLLTTV GSLLEDETYT VRVLAFTSVG
DGPLSDPIQV KTQQGVPGQP MNFRAEAKSE TSIGLSWSPP RQDSIIKYEL LFREGDHGRE
VPRAQCTETD RPPRWPCPPR QGPPLPGAGV GGVGVQVPGQ ALESLELFAV PALPPCHRQV
TFCTRSTAIL VSWRPPPPET HNGALVSYSV RYRPLGSEDP QPKEVNGIPP TTTQILLEAL
DKWTEYRITT VAHTEVGPGP ESSPVVIRTD EDVPSAPPRK VEAEALNATA IRVLWRSPAP
GRQHGQIRGY QVHYVRMEGA EARGPPRIKD IMLADAQWEM DDTAEYEMVI ANLQPETAYS
ITVAAYTMKG DGARSKPKVV VTKGAVLGRP TLSVQQTPEG SLLAHWEPPA GTAEDQVLGY
RLQFGREDSP LATLEFPPTE DHYTALGVHK GATYVFRLAA RSRGGLGEEA AEVLSIPEDT
PRGHPQILEA AGNASAGTVL LRWLPPVPAE RNGAIVKYTV AVREAGALGP ARETELPAAA
EPGAENVLTL QGLKPDTAYD LQVRAHTRQG PGPYSPPVRY RTFLRDQVSP KNFKVKMIMK
TSVLLSWEFP DNYNSPTPYK IQYNGLTLDV DGRTTKKLIT HLKPNTFYNF VLTNRGSSLG
GLQQTVTAWT AFNLLRTPLP TSSRHCSHVA PDPSSPYRSY FIVMVPLRKS RGGQFLTPLG
SPEDMDLEEL IQDISRLQRR SLRHSRQLEA PRPYIAARFS MLPSTFHPGD QKQYGGFDNR
GLEPGHRYVL FVLAVLQKSE PVSPKRYPFQ LDNPDPQPIV DGEEGLIWVI GPVLAVVFII
CIVIAILLYK NKRKDSEPRT KCLLNNADLA PHHPKDPVEM RRINFQTPGM LSHPPIPIAD
MAEHTERLKA NDSLKLSQEY ESIDPGQQFT WEHSNLEVNK PKNRYANVIA YDHSRVILQP
IEGIVGSDYI NANYVDGYRR QNAYIATQGP LPETFGDFWR MVWEQRSATI VMMTRLEEKS
RIKCDQYWPN RGTETYGFIQ VTLLDTIELA TFCVRTFSLH KNGSSEKREV RQFQFTAWPD
HGVPEYPTPF LAFLRRVKTC NPPDAGPVVV HCSAGVGRTG CFIVIDAMLE RIKPEKTVDV
YGHVTLMRSQ RNYMVQTEDQ YSFIHEALLE AVGCGNTEVP ARSLYAYIQK LAQVEPGEHV
TGMELEFKRL ANSKAHTSRF ISANLPCNKF KNRLVNIMPY ESTRVCLQPI RGVEGSDYIN
ASFIDGYRQQ KAYIATQGPL AETTEDFWRM LWENNSTIVV MLTKLREMGR EKCHQYWPAE
RSARYQYFVV DPMAEYNMPQ YILREFKVTD ARDGQSRTVR QFQFTDWPEQ GVPKSGEGFI
DFIGQVHKTK EQFGQDGPIS VHCSAGVGRT GVFITLSIVL ERMRYEGVVD IFQTVKMLRT
QRPAMVQTED EYQFCYQAAL EYLGSFDHYA T
//