ID A0A452RCZ3_URSAM Unreviewed; 964 AA.
AC A0A452RCZ3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=IQ motif and Sec7 domain ArfGEF 1 {ECO:0000313|Ensembl:ENSUAMP00000016589.1};
GN Name=IQSEC1 {ECO:0000313|Ensembl:ENSUAMP00000016589.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000016589.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000016589.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BRAG family.
CC {ECO:0000256|ARBA:ARBA00006248}.
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DR AlphaFoldDB; A0A452RCZ3; -.
DR Ensembl; ENSUAMT00000018572.1; ENSUAMP00000016589.1; ENSUAMG00000013109.1.
DR GeneTree; ENSGT00940000156915; -.
DR OMA; AGHSAHH; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13318; PH_IQSEC; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR033742; IQSEC_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF327; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF16453; IQ_SEC7_PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 497..690
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 910..929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..384
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 964 AA; 108057 MW; 41DAF3A522A1A31C CRC64;
MYVEGEAPSS ETGTSLDSPS AYHQGPLAPA SSLSPDRYEH TSVGAYGLYS GPPGQQQRTR
RPKLQHSTSI LRKQAEEEAI KRSRSLSESY ELSSDLQDKQ VEMLERKYGG RLVTRHAART
IQTAFRQYQM NKNFERLRSS MSENRMSRRI VLSNMRMQFS FEGPEKVHSS YFEGKQVSVT
DDGSQLGALV PSECSDLGEP PTLKSPAPSS DFTDAITELE DAFSRQVKSL AESIDDALNC
RSLHAEEAPA PDAGRARDAE PKPALHGVDH HKLDEMTASY SDVTLYIDEE ELSPPLPLSQ
AGHRPPSTES DLRLRAGGAA QDYWALAHKD DKGDTDTSCR STPSLERQEQ RLRVEHLPLL
TIEPPSDSSV ELSDRSDRSS LKRQSAYERS LGGPQGSPKH GPLGGPPKGL PREEPELRPR
PPRPLDSHLA INGSANRQSK SESDYSDGDN DSINSTSNSN DTINCSSESS SRDSLREQTL
SKQTYHKETR NSWDSPAFSN DVIRKRHYRI GLNLFNKKPE KGVQYLIERG FVPDTPVGVA
HFLLQRKGLS RQMIGEFLGN RQKQFNRDVL DCVVDEMDFS AMELDEALRK FQAHIRVQGE
AQKVERLIEA FSQRYCICNP GVVRQFRNPD TIFILAFAII LLNTDMYSPN VKPERKMKLE
DFVKNLRGVD DGEDIPREML VGIYERIRKR ELKTNEDHVS QVQKVEKLIV GKKPIGSLHH
GLGCVLSLPH RRLVCYCRLF EVPDPNKPQK LGLHQREIFL FNDLLVVTKI FQKKKNSVTY
SFRQSFSLYG MQVLLFENQY YPNGIRLTSA VPGADIKVLI NFNAPNPQDR KKFTDDLRES
IAEVQEMEKH RIESELEKQK GVVRPSMSQC SSLKKESGNG TLSRACLDDS YASGEGLKRS
ALSSSLRDLS EAGKSRAGPP FLAQRMQDSD RAAGARIVRQ EGHAVVAGGG RAQTEHFPVT
IPKP
//
