ID A0A452RDB0_URSAM Unreviewed; 497 AA.
AC A0A452RDB0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Rac/Cdc42 guanine nucleotide exchange factor 6 {ECO:0000313|Ensembl:ENSUAMP00000016685.1};
GN Name=ARHGEF6 {ECO:0000313|Ensembl:ENSUAMP00000016685.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000016685.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000016685.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A452RDB0; -.
DR Ensembl; ENSUAMT00000018680.1; ENSUAMP00000016685.1; ENSUAMG00000013242.1.
DR GeneTree; ENSGT00940000158723; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01225; PH_Cool_Pix; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR032409; GEF6/7_CC.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR046376; PH_Cool_Pix.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46026:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6; 1.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF16523; betaPIX_CC; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16614; RhoGEF67_u2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 16..196
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 218..322
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 329..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 439..480
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 329..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 497 AA; 56781 MW; 726629A20603E729 CRC64;
MILCLLRPFP RINDLKPMKV LQNILDTEKD YAKELQSLLV TYLRPLQSNN NLSSVEFTSL
LGNFEEVCSF QQTLCQALEE CSKFPENQHK VGGCLLNLMP HFKSMYLSYC ANHPAAVSVL
TQHSDDLEQF MESQGASSPG ILILTTSLSK PFMRLEKYVT LLQELERHME DTHPDHQDIL
KAIIAFKTLM GQCQDLRKRK QLELQILSEP IQAWEGESIK TLGNVLFMSQ VMVQYGTCEE
KEERYLLLFS SVLIMLSASP RMSGFIYQGK IPVAGMVVTR LDEIEGNDNT FEITGNMERI
VIHCNNSQDF QEWLEQLCRL IRGPASCSSL SKTSSSSCSA HSESSKSPKT MKKFLHKRKT
ERKPSEEEYV IRKSTAALEE DAQILKVIEA YCTSANFQQG ARKDSLPQVL LPEEEKLIIE
ETRSNGQTII EEKSLVDTVY ALKDEVKELK QENKRMKQCL EEELKSRRDL EKLVRRLLKQ
TDECIRAESS SKTSILP
//
