ID A0A452RDC7_URSAM Unreviewed; 747 AA.
AC A0A452RDC7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN Name=CLCN7 {ECO:0000313|Ensembl:ENSUAMP00000016729.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000016729.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000016729.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
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DR AlphaFoldDB; A0A452RDC7; -.
DR STRING; 9643.ENSUAMP00000016729; -.
DR Ensembl; ENSUAMT00000018732.1; ENSUAMP00000016729.1; ENSUAMG00000013295.1.
DR GeneTree; ENSGT00940000158458; -.
DR OMA; MFMNPSP; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0034707; C:chloride channel complex; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030321; P:transepithelial chloride transport; IEA:Ensembl.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03685; ClC_6_like; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR002249; Cl_channel-7.
DR PANTHER; PTHR11689; CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER; 1.
DR PANTHER; PTHR11689:SF166; H(+)_CL(-) EXCHANGE TRANSPORTER 7; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR PRINTS; PR01118; CLCHANNEL7.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703}; Chloride {ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 69..90
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 118..139
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 169..187
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 230..253
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 265..287
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 317..341
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 353..375
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 430..448
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 460..483
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 489..511
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 523..544
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 683..741
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 747 AA; 82586 MW; BAED3579CC1BB3B0 CRC64;
MSNVELDDEL LDPEMDPPHP FPKEIPHNEK LLSLKYESLD YDNSENQLFL EEERRINHTA
FRTVEMKRWV ICAMIGILTG LVACFIDIVV ENVAGLKYKV VKDNIDKFTE RGGLSFSLLL
WATLNSAFVL VGSAIVAFVE PVAAGSGIPQ IKCFLNGVKI PHVVRLKTLV IKVSGVILSV
VGGLAVGKEG PMIHSGSVIA AGISQGRSTS LKRDFKIFEY FRRDTEKRDF VSAGAAAGVS
AAFGAPVGGV LFSLEEGASF WNQFLTWRIF FASMISTFTL NFVLSIYHGN IWDLSSPGLI
NFGRFDTETM VYTIHEIPIF IAMGVVGGIL GAVFNALNYW LTMFRIRYIH RPCLQVIEAM
LVAAVTATVA FVLIYSSRDC QPLQGSSVSY PLQLFCADGE YNSMAAAFFN TPEKSVVSLF
HDPPGSYNPM TLGLFTLVYF FLACWTYGLT VSAGVFIPSL LIGAAWGRLF GISLSYLTGA
AIWADPGKYA LMGAAAQLGG IVRMTLSLTV IMMEATSNVT YGFPIMLVLM TAKIVGDIFI
EGLYDMHIQL QSVPFLHWEA PVTSHSLTAR EVMSTPVTCL RRREKVGVIV DILSNTASNH
NGFPVVEFAG DTQPARLQGL ILRSQLIVLL KHKVFVERSS MGLVRRRLRL KDFRDAYPRF
PPIQSIHVSQ DERECTMDLS EFMNPSPYTV PQDASLPRVF KLFRALGLRH LVVVDNCNQV
VGLVTRKDLA RYRLGKGGLE ELSLAQT
//
