ID A0A452RFW4_URSAM Unreviewed; 874 AA.
AC A0A452RFW4;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=F-box protein 11 {ECO:0000313|Ensembl:ENSUAMP00000017708.1};
GN Name=FBXO11 {ECO:0000313|Ensembl:ENSUAMP00000017708.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000017708.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000017708.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR AlphaFoldDB; A0A452RFW4; -.
DR Ensembl; ENSUAMT00000019818.1; ENSUAMP00000017708.1; ENSUAMG00000013908.1.
DR GeneTree; ENSGT00530000063425; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd22091; F-box_FBXO11; 1.
DR CDD; cd19676; UBR-box_UBR6_FBXO11; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 3.
DR InterPro; IPR039448; Beta_helix.
DR InterPro; IPR006633; Carb-bd_sugar_hydrolysis-dom.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR047505; F-box_FBXO11.
DR InterPro; IPR047504; FBXO11_UBR-box.
DR InterPro; IPR022441; Para_beta_helix_rpt-2.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR InterPro; IPR003126; Znf_UBR.
DR NCBIfam; TIGR03804; para_beta_helix; 4.
DR PANTHER; PTHR22990; F-BOX ONLY PROTEIN; 1.
DR PANTHER; PTHR22990:SF20; F-BOX ONLY PROTEIN 11; 1.
DR Pfam; PF13229; Beta_helix; 2.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF02207; zf-UBR; 1.
DR SMART; SM00722; CASH; 3.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00710; PbH1; 19.
DR SMART; SM00396; ZnF_UBR1; 1.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF51126; Pectin lyase-like; 3.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS51157; ZF_UBR; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..874
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019487771"
FT DOMAIN 100..146
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT DOMAIN 780..851
FT /note="UBR-type"
FT /evidence="ECO:0000259|PROSITE:PS51157"
FT ZN_FING 780..851
FT /note="UBR-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00508"
FT REGION 60..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 874 AA; 97299 MW; 4915190E24C4B483 CRC64;
QTSFLPFLSS STLCHSLSLC TVCVDDDVPA DMVAEESGPG AQNSPYQLRR KTLLPKRTAC
PTKSSMEGAS TSTTENFGHR AKRARVSGKS QDLSAAPAEQ YLQEKLPDEV VLKIFSYLLE
QDLCRAACVC KRFSELANDP ILWKRLYMEV FEYTRPMMHP EPGKFYQINP EEYEHPNPWK
ESFQQLYKGA HVKPGFAEHF YSNPARYKGR ENMLYYDTIE DALGGVQEAH FDGLIFVHSG
IYTDEWIYIE SPITMIGAAP GKVADKVIIE NTRDSTFVFM EGSEDAYVGY MTIRFNPDDK
SAQHHNAHHC LEITVNCSPI IDHCIIRSTC TVGSAVCVSG QGACPTIKHC NISDCENVGL
YITDHAQGIY EDNEISNNAL AGIWVKNHGN PIIRRNHIHH GRDVGVFTFD HGMGYFESCN
IHRNRIAGFE VKAYANPTVV RCEIHHGQTG GIYVHEKGRG QFIENKIYAN NFAGVWITSN
SDPTIRGNSI FNGNQGGVYI FGDGRGLIEG NDIYGNALAG IQIRTNSCPI VRHNKIHDGQ
HGGIYVHEKG QGVIEENEVY SNTLAGVWVT TGSTPVLRRN RIHSGKQVGV YFYDNGHGVL
EDNDIYNHMY SGVQIRTGSN PKIRRNKIWG GQNGGILVYN SGLGCIEDNE IFDNAMAGVW
IKTDSNPTLR RNKIHDGRDG GICIFNGGRG LLEENDIFRN AQAGVLISTN SHPVLRKNRI
FDGFAAGIEI TNHATATLEG NQIFNNRFGG LFLASGVNVT MKDNKIMNNQ DAIEKAVSRG
QCLYKISSYT SYPMHDFYRC HTCNTTDRNA ICVNCIKKCH QGHDVEFIRH DRFFCDCGAG
TLSNPCTLAG EPTHDTDTLY DSAPPIESNT LQHN
//
