ID   A0A452RGN3_URSAM        Unreviewed;       405 AA.
AC   A0A452RGN3;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Potassium channel tetramerization domain containing 18 {ECO:0000313|Ensembl:ENSUAMP00000018000.1};
GN   Name=KCTD18 {ECO:0000313|Ensembl:ENSUAMP00000018000.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000018000.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000018000.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A452RGN3; -.
DR   STRING; 9643.ENSUAMP00000018000; -.
DR   Ensembl; ENSUAMT00000020152.1; ENSUAMP00000018000.1; ENSUAMG00000014291.1.
DR   GeneTree; ENSGT00530000064234; -.
DR   OMA; CKAGPKP; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   CDD; cd18372; BTB_POZ_KCTD18; 1.
DR   InterPro; IPR045704; KCTD18_C.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   PANTHER; PTHR14499:SF4; BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD18; 1.
DR   PANTHER; PTHR14499; POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING; 1.
DR   Pfam; PF02214; BTB_2; 1.
DR   Pfam; PF19321; KCTD18_C; 1.
DR   SUPFAM; SSF54695; POZ domain; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT   DOMAIN          14..98
FT                   /note="Potassium channel tetramerisation-type BTB"
FT                   /evidence="ECO:0000259|Pfam:PF02214"
FT   DOMAIN          114..391
FT                   /note="BTB/POZ"
FT                   /evidence="ECO:0000259|Pfam:PF19321"
FT   REGION          263..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        279..302
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        384..398
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   405 AA;  44097 MW;  B941C8A864B6933D CRC64;
     MEGHKAEEKV LDILRLNVGG CIYTARRESL CRFKDSMLAS MFSGRFPLKT DESGACVIDR
     DGHLFKYLLD YLHGEVHIPT DEQTRIALQE EADYFGIPYP YSLSDHLANE METYSLRSNI
     ELKKALTDFC DSYGLVCNKP TVWVLHYLNT SGASCESRII GVYSTKTDGT DAIDKQLGGR
     IHSKSIFKRE AGNNVQYIWS YYSVAELKKM MDAFDAWEGK GVSYWRVPHE LIECWTLEER
     PLLGSLRHMA PIRKRRLMAF NEEEDEGVNC KTGPKPVRFL GPSTSTQIKV KNSASVRVSP
     AGTLQSAGGK AALRSAPPKA PSPAGTALPG QPQAPRGAGS AENGAAHPPP AKVLLSDKKA
     TPPRVIKLKR TPLCAAGPCP PAGAGARPAG PPVPAPEAPG AHART
//