ID   A0A452RH93_URSAM        Unreviewed;       457 AA.
AC   A0A452RH93;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Catenin alpha 1 {ECO:0008006|Google:ProtNLM};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000018323.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000018323.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the vinculin/alpha-catenin family.
CC       {ECO:0000256|ARBA:ARBA00008376}.
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DR   AlphaFoldDB; A0A452RH93; -.
DR   Ensembl; ENSUAMT00000020508.1; ENSUAMP00000018323.1; ENSUAMG00000014537.1.
DR   GeneTree; ENSGT01030000234543; -.
DR   OMA; ESHILEY; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0045296; F:cadherin binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 2.
DR   Gene3D; 1.20.120.810; Vinculin, Vh2 four-helix bundle; 1.
DR   InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR   InterPro; IPR001033; Alpha_catenin.
DR   InterPro; IPR006077; Vinculin/catenin.
DR   PANTHER; PTHR18914; ALPHA CATENIN; 1.
DR   PANTHER; PTHR18914:SF24; CATENIN ALPHA-1; 1.
DR   Pfam; PF01044; Vinculin; 1.
DR   PRINTS; PR00805; ALPHACATENIN.
DR   SUPFAM; SSF47220; alpha-catenin/vinculin-like; 3.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT   REGION          415..445
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        415..435
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   457 AA;  50573 MW;  A36551563770C398 CRC64;
     VRMSASQLEA LCPQVINAAL ALAAKPQSKL AQENMDLFKE QWEKQVRVLT DAVDDITSID
     DFLAVSENHI LEDVNKCVIA LQEKDVDGLD RTAGAIRGRA ARVIHVVTSE MDNYEPGVYT
     EKVLEATKLL SNTVMPRFTE QVEAAVEALS SDPAQPMDEN EFIDASRLVY DGIRDIRKAV
     LMIRTPEELD DSDFETEDFD VRSRTSVQTE DDQLIAGQSA RAIMAQLPQE QKAKIAEQVA
     SFQEEKSKLD AEVSKWDDSG NDIIVLAKQM CMIMMEMTDF TRGKGPLKNT SDVISAAKKI
     AEAGSRMDKL GRTIADHCPD SACKQDLLAY LQRIALYCHQ LNICSKVKAE VQNLGGELVV
     SGVDSAMSLI QAAKNLMNAV VQTVKASYVA STKYQKSQGM ASLNLPAVSW KMKAPEKKPL
     VKREKQDETQ TKIKRASQKK HVNPVQALSE FKAMDSI
//