ID A0A452RHF9_URSAM Unreviewed; 2049 AA.
AC A0A452RHF9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Spectrin beta chain {ECO:0000256|PIRNR:PIRNR002297};
GN Name=SPTBN2 {ECO:0000313|Ensembl:ENSUAMP00000018344.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000018344.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000018344.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826, ECO:0000256|PIRNR:PIRNR002297}.
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DR Ensembl; ENSUAMT00000020530.1; ENSUAMP00000018344.1; ENSUAMG00000005142.1.
DR GeneTree; ENSGT00940000158847; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProt.
DR GO; GO:0008091; C:spectrin; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:UniProtKB-UniRule.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-UniRule.
DR CDD; cd21246; CH_SPTB-like_rpt1; 1.
DR CDD; cd21321; CH_SPTBN2_rpt2; 1.
DR CDD; cd10571; PH_beta_spectrin; 1.
DR CDD; cd00176; SPEC; 6.
DR Gene3D; 1.20.58.60; -; 12.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR016343; Spectrin_bsu.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF325; SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 2; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF00435; Spectrin; 14.
DR PIRSF; PIRSF002297; Spectrin_beta_subunit; 3.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00033; CH; 2.
DR SMART; SM00150; SPEC; 15.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 10.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467,
KW ECO:0000256|PIRNR:PIRNR002297};
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR002297}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR002297};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR002297};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 57..161
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 176..281
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1883..1987
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1814..1879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1990..2049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 992..1019
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1098..1125
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1855..1869
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2028..2049
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2049 AA; 232434 MW; 5FFEBFF4C7A3450D CRC64;
MSSTLSPTDF DSLEIQGQYS DINNRWDLPD SDWDNDSSSA RLFERSRIKA LADEREAVQK
KTFTKWVNSH LARVTCRVGD LYSDLRDGRN LLRLLEVLSG ETLPKPTKGR MRIHCLENVD
KALQFLKEQK VHLENMGSHD IVDGNHRLTL GLVWTIILRF QIQDISVETE DNKEKKSAKD
ALLLWCQMKT AGYPNVNVHN FTTSWRDGLA FNAIVHKHRP DLLDFESLKK CNAHYNLQNA
FNLAEKELGL TKLLDPEDVN VDQPDEKSII TYVATYYHYF SKMKALAVEG KRIGKVLDHA
MEAERLVEKY ESLASELLQW IEQTIVTLND RQLANSLSGV QNQLQSFNSY RTVEKPPKFT
EKGNLEVLLF TIQSKLRANN QKVYTPREGR LISDINKAWE RLEKAEHERE LALRTELIRQ
EKLEQLAARF DRKAAMRETW LSENQRLVSQ DNFGLELAAV EAAVRKHEAI ETDIVAYSGR
VQAVDAVAAE LAAERYHDIK RIAARQHNVA RLWDFLRQMV AARRERLLLN LELQKVFQDL
LYLMDWMEEM KGRLQSPDLG KHLAGVEDLL QLHELVEADI AVQAERVRAV SASALRFCDP
EYKPCDPQLV SERVASLERS YEALCKLAAA RRARLEESRR LWRFLWEVGE AEAWVREQQH
LLASAETGRD LTGVLRLLNK HTALRGEMSG RLGPLKLTLE QGQQLVAEGH PGAGQAAART
AELQAQWERL EALAEERAQR LAQAASLYQF QADANDMEAW LVDALRLVSS PELGHDEFST
QALARQHRAL EEEIRSHRPA LDALREQAAA LPPALSHTPE VQGRVPSLER HYEQLQARAG
ERARALEAAL ALYTMLSEAG ACGLWVEEKE QWLNGLALPE RLEDLEVVQQ RFETLEPEMN
ALAARITAVN DIAEQLLKAK PPSRDSIVDT QKQLNHRWQQ FRTLADGKKA ALTSALSIQN
YHLECTETQA WMREKTKVIE STQGLGNDLA GVLALQRKLA GTERDLEAIA ARVGELTREA
NALAAGHPAQ APAINARLGE VQAGWEDLRA TMRRREESLG EARRLQDFLR SLDDFQAWLG
RTQTSVASEE GPATLPEAEA LLAQHAALRG EVERARGEYS RLRALGEEVT RDQADPQCLF
LRQRLEALGT GWEELGRMWE SRQGRLAQAH GFQGFLRDAR QAEGVLSSQE YVLSHTEMPG
TLQAADAAIK NLEDFMSTMD ANGERIRGLL EAGRQLVSAG NIHAEKIQEK ADSIERRHKK
NQEVVQQLLG RLRDNREQQH FLQDCHELKL WIDEKMLTAQ DVSYDEARNL HTKWQKHQAF
MAELAANKDW LDKVDKEGRE LTLEKPELKA LVSEKLEDLH KRWDRLESTT QAKARSLFDA
NRAELFAQSC SALESWLESL QAQLHSDDYG KDLTSVNILL KKQQVLCRCW NGRWLCERRR
TSRAVEEKFR ALCQPMKERC RRLQASREQH QFHRDVEDEI LWVTERLPMA SSMEHGKDLP
SVQLLMKKNQ TLQKEIQGHE PRIADLTERQ RALGAVAAGP ELAELQEMWK RLSRELELRG
KRLEAALRAQ QFYRDAAEAE AWMGEQELHM MGQEKAKDEL SAQAEVKKHQ GLEQALADYA
QTVHQLAASS QDMIDHDHPE STRISIRQAQ VDKLYASLKE LAGERRERLQ EHLRLCQLRR
ELDDLEQWIQ EREVVAASHE LGQDYEHVTV SAGWTPAISE KLSQLQARRQ ETADKWQEKM
DWLQLVLEVL VFGRDAGMAE AWLCSQEPLV RSAELGCTVD EVESLIKRHE AFQKSAVAWE
ERFSALEKLT AVRAGGPQEC PPSPTAPGLC SPGSGTGDEA NGPRGEKQPR TRGPAPSVMP
QSRSSESARV ATLPPRGPEL SAQEQMEGML CRKQEMEAFG KKAANRSWQN VYCVLRRGSL
GFYKDAKAAS TGVPYHGEVP VSLARAQGSV AFDYRKRKHV FNCLRAPASQ QPCEMSSWLR
VVNAAIATAS SASGEPEEPA VPSATRGMTR AMTMPPVSPV GAEGPVVLRS KDGREREREK
RFSFFKKSK
//
