ID A0A452RHH5_URSAM Unreviewed; 779 AA.
AC A0A452RHH5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Rho GTPase activating protein 17 {ECO:0000313|Ensembl:ENSUAMP00000018418.1};
GN Name=ARHGAP17 {ECO:0000313|Ensembl:ENSUAMP00000018418.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000018418.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000018418.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A452RHH5; -.
DR Ensembl; ENSUAMT00000020611.1; ENSUAMP00000018418.1; ENSUAMG00000014069.1.
DR GeneTree; ENSGT00940000156201; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04386; RhoGAP_nadrin; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047165; RHG17/44/SH3BP1-like.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14130; 3BP-1 RELATED RHOGAP; 1.
DR PANTHER; PTHR14130:SF3; RHO GTPASE-ACTIVATING PROTEIN 17; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 1..224
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 230..420
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 437..761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..551
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 642..666
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..687
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..716
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 723..755
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 779 AA; 84418 MW; D6DCD5DEE84B2C6A CRC64;
MARLSLFCQI ERRLDTVRSM CHHSHKRLMA CFQGQHGTDA ERRYKKLPLT ALAQNMQEAS
TQLEESLLGK MLETCGDAEN QLALELTQHE VFVEREIVEP LCSIAEVEIP NIQKQRKQLA
KLVLDWDSVR ARWNQAHKSS GTNFQGLPSK IDTLKEEMDE AGNKVELCKD QLAADMYNFM
AKEGEYGKFF VTLLEAQADY HRKALAVLEK ALPEMRAHQD KWAEKPAFGT PLEEHLKRSG
REIALPIEAC VMLLLETGMK EEGLFRIGAG ASKLKKLKAA LDCSTSHLDE FYSDPHAVAG
ALKSYLRELP EPLMTFNLYE EWTQVASVQD QDKKLQDLWR TCQKLPPQNF VNFRYLIKFL
AKLAQTSDVN KMTPSNIAIV LGPNLLWAKT EGTLAEMAAA TSVHVVAVIE PIIQHADWFF
PEEVEFNVSE AFVPLVTPNS NHSSHTGNDS DSGTLERKRP ASMAVMEGDL VKKESPPKPK
DSTPAPAPGR NSSQMAASQN QAPMAAGSHQ LSVGPGHNSA GPSPHTLRRA VKKPAPAPPK
PGNPPPGHPG GQSSPGTSQH PPSLSPKPAT RSPSPPTQHA GQAPGQPCTT SQPSAPRRYS
SSLSPIQAPS HPPPQPPTQT ALLGHSKPGS QGPSAPATLP SEPGLEQPPH TPPQTPTPPS
TPPLGKQNPS LPASQTQAVS NPETAQPHAG TLPRPRPVPK PRNRPSVPPP PHPPGAHSAG
DGTLTNAAPT ASKIVTDTSS RVSEPLRSTF PDMHSDSASK DLPGRILLDI DNDTESTAL
//
