ID A0A452RIQ3_URSAM Unreviewed; 2043 AA.
AC A0A452RIQ3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Spectrin beta chain {ECO:0000256|PIRNR:PIRNR002297};
GN Name=SPTBN2 {ECO:0000313|Ensembl:ENSUAMP00000018845.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000018845.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000018845.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826, ECO:0000256|PIRNR:PIRNR002297}.
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DR Ensembl; ENSUAMT00000021084.1; ENSUAMP00000018845.1; ENSUAMG00000005142.1.
DR GeneTree; ENSGT00940000158847; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProt.
DR GO; GO:0008091; C:spectrin; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:UniProtKB-UniRule.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-UniRule.
DR CDD; cd21246; CH_SPTB-like_rpt1; 1.
DR CDD; cd21321; CH_SPTBN2_rpt2; 1.
DR CDD; cd10571; PH_beta_spectrin; 1.
DR CDD; cd00176; SPEC; 7.
DR Gene3D; 1.20.58.60; -; 12.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR016343; Spectrin_bsu.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF325; SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 2; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF00435; Spectrin; 13.
DR PIRSF; PIRSF002297; Spectrin_beta_subunit; 2.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00033; CH; 2.
DR SMART; SM00150; SPEC; 15.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 11.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467,
KW ECO:0000256|PIRNR:PIRNR002297};
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR002297}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR002297};
KW Cytoskeleton {ECO:0000256|PIRNR:PIRNR002297};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 57..161
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 176..281
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 1811..1888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1900..1921
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 992..1019
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1098..1125
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1830..1852
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2043 AA; 232133 MW; 1E6DAD5A8654BA88 CRC64;
MSSTLSPTDF DSLEIQGQYS DINNRWDLPD SDWDNDSSSA RLFERSRIKA LADEREAVQK
KTFTKWVNSH LARVTCRVGD LYSDLRDGRN LLRLLEVLSG ETLPKPTKGR MRIHCLENVD
KALQFLKEQK VHLENMGSHD IVDGNHRLTL GLVWTIILRF QIQDISVETE DNKEKKSAKD
ALLLWCQMKT AGYPNVNVHN FTTSWRDGLA FNAIVHKHRP DLLDFESLKK CNAHYNLQNA
FNLAEKELGL TKLLDPEDVN VDQPDEKSII TYVATYYHYF SKMKALAVEG KRIGKVLDHA
MEAERLVEKY ESLASELLQW IEQTIVTLND RQLANSLSGV QNQLQSFNSY RTVEKPPKFT
EKGNLEVLLF TIQSKLRANN QKVYTPREGR LISDINKAWE RLEKAEHERE LALRTELIRQ
EKLEQLAARF DRKAAMRETW LSENQRLVSQ DNFGLELAAV EAAVRKHEAI ETDIVAYSGR
VQAVDAVAAE LAAERYHDIK RIAARQHNVA RLWDFLRQMV AARRERLLLN LELQKVFQDL
LYLMDWMEEM KQGRLQSPDL GKHLAGVEDL LQLHELVEAD IAVQAERVRA VSASALRFCD
PGKEYKPCDP QLVSERVASL ERSYEALCKL AAARRARLEE SRRLWRFLWE VGEAEAWVRE
QQHLLASAET GRDLTGVLRL LNKHTALRGE MSGRLGPLKL TLEQGQQLVA EGHPGAGQAA
ARTAELQAQW ERLEALAEER AQRLAQAASL YQFQADANDM EAWLVDALRL VSSPELGHDE
FSTQALARQH RALEEEIRSH RPALDALREQ AAALPPALSH TPEVQGRVPS LERHYEQLQA
RAGERARALE AALALYTMLS EAGACGLWVE EKEQWLNGLA LPERLEDLEV VQQRFETLEP
EMNALAARIT AVNDIAEQLL KAKPPSRDSI VDTQKQLNHR WAWGGEPRRA ALTSALSIQN
YHLECTETQA WMREKTKVIE STQGLGNDLA GVLALQRKLA GTERDLEAIA ARVGELTREA
NALAAGHPAQ APAINARLGE VQAGWEDLRA TMRRREESLG EARRLQDFLR SLDDFQAWLG
RTQTSVASEE GPATLPEAEA LLAQHAALRG EVERARGEYS RLRALGEEVT RDQADPQCLF
LRQRLEALGT GWEELGRMWE SRQGRLAQAH GFQGFLRDAR QAEGVLSSQE YVLSHTEMPG
TLQAADAAIK NLEDFMSTMD ANGERIRGLL EAGRQLVSAG NIHAEKIQEK ADSIERRHKK
NQEVVQQLLG RLRDNREQQH FLQDCHELKL WIDEKMLTAQ DVSYDEARNL HTKWQKHQAF
MAELAANKDW LDKVDKEGRE LTLEKPELKA LVSEKLEDLH KRWDRLESTT QAKARSLFDA
NRAELFAQSC SALESWLESL QAQLHSDDYG KDLTSVNILL KKQQMAVREK EVEAIQAQAT
ALAQEDQGAG EVERTSRAVE EKFRALCQPM KERCRRLQAS REQHQFHRDV EDEIVRGPRQ
SVLFCHRGQT LQKEIQGHEP RIADLTERQR ALGAVAAGPE LAELQEMWKR LSRELELRGK
RLEAALRAQQ FYRDAAEAEA WMGEQELHMM GQEKAKDELS AQAEVKKHQG LEQALADYAQ
TVHQLAASIP RCLPRSHSTR ISIRQAQVDK LYASLKELAG ERRERLQEHL RLCQLRRELD
DLEQWIQERE VVAASHELGQ DYEHVTVSAG WTPAISEKLS QLQARRQETA DKWQEKMDWL
QLVLEVLVFG RDAGMAEAWL CSQEPLVRSA ELGCTVDEVE SLIKRHEAFQ KSAVAWEERF
SALEKLTAVR AGGPQECPPS PTAPGLCSPL EEQEKERKRK REEEERRKQP PAPEPTAIRP
EGDLADGRMA PDAAWDGGFP AVPSWKDGEE GPCRRRVLWD RGGPREESGT GSPWTPEPVT
RLTYTTVPPR SWQNVYCVLR RGSLGFYKDA KAASTGVPYH GEVPVSLARA QGSVAFDYRK
RKHVFKLGLQ DGKEYLFQAK DEVSWPLLLP RSHLSAPFSV HSSCRFPSLP SFSLSKCLVP
PDR
//