GenomeNet

Database: UniProt
Entry: A0A452RIQ3_URSAM
LinkDB: A0A452RIQ3_URSAM
Original site: A0A452RIQ3_URSAM 
ID   A0A452RIQ3_URSAM        Unreviewed;      2043 AA.
AC   A0A452RIQ3;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=Spectrin beta chain {ECO:0000256|PIRNR:PIRNR002297};
GN   Name=SPTBN2 {ECO:0000313|Ensembl:ENSUAMP00000018845.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000018845.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000018845.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the spectrin family.
CC       {ECO:0000256|ARBA:ARBA00006826, ECO:0000256|PIRNR:PIRNR002297}.
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DR   Ensembl; ENSUAMT00000021084.1; ENSUAMP00000018845.1; ENSUAMG00000005142.1.
DR   GeneTree; ENSGT00940000158847; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProt.
DR   GO; GO:0008091; C:spectrin; IEA:InterPro.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:UniProtKB-UniRule.
DR   GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-UniRule.
DR   CDD; cd21246; CH_SPTB-like_rpt1; 1.
DR   CDD; cd21321; CH_SPTBN2_rpt2; 1.
DR   CDD; cd10571; PH_beta_spectrin; 1.
DR   CDD; cd00176; SPEC; 7.
DR   Gene3D; 1.20.58.60; -; 12.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR001589; Actinin_actin-bd_CS.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041681; PH_9.
DR   InterPro; IPR001605; PH_dom-spectrin-type.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR016343; Spectrin_bsu.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   PANTHER; PTHR11915:SF325; SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 2; 1.
DR   PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR   Pfam; PF00307; CH; 2.
DR   Pfam; PF15410; PH_9; 1.
DR   Pfam; PF00435; Spectrin; 13.
DR   PIRSF; PIRSF002297; Spectrin_beta_subunit; 2.
DR   PRINTS; PR00683; SPECTRINPH.
DR   SMART; SM00033; CH; 2.
DR   SMART; SM00150; SPEC; 15.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF46966; Spectrin repeat; 11.
DR   PROSITE; PS00019; ACTININ_1; 1.
DR   PROSITE; PS00020; ACTININ_2; 1.
DR   PROSITE; PS50021; CH; 2.
PE   3: Inferred from homology;
KW   Actin capping {ECO:0000256|ARBA:ARBA00022467,
KW   ECO:0000256|PIRNR:PIRNR002297};
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW   ECO:0000256|PIRNR:PIRNR002297}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR002297};
KW   Cytoskeleton {ECO:0000256|PIRNR:PIRNR002297};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          57..161
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          176..281
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   REGION          1811..1888
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1900..1921
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          992..1019
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1098..1125
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1830..1852
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2043 AA;  232133 MW;  1E6DAD5A8654BA88 CRC64;
     MSSTLSPTDF DSLEIQGQYS DINNRWDLPD SDWDNDSSSA RLFERSRIKA LADEREAVQK
     KTFTKWVNSH LARVTCRVGD LYSDLRDGRN LLRLLEVLSG ETLPKPTKGR MRIHCLENVD
     KALQFLKEQK VHLENMGSHD IVDGNHRLTL GLVWTIILRF QIQDISVETE DNKEKKSAKD
     ALLLWCQMKT AGYPNVNVHN FTTSWRDGLA FNAIVHKHRP DLLDFESLKK CNAHYNLQNA
     FNLAEKELGL TKLLDPEDVN VDQPDEKSII TYVATYYHYF SKMKALAVEG KRIGKVLDHA
     MEAERLVEKY ESLASELLQW IEQTIVTLND RQLANSLSGV QNQLQSFNSY RTVEKPPKFT
     EKGNLEVLLF TIQSKLRANN QKVYTPREGR LISDINKAWE RLEKAEHERE LALRTELIRQ
     EKLEQLAARF DRKAAMRETW LSENQRLVSQ DNFGLELAAV EAAVRKHEAI ETDIVAYSGR
     VQAVDAVAAE LAAERYHDIK RIAARQHNVA RLWDFLRQMV AARRERLLLN LELQKVFQDL
     LYLMDWMEEM KQGRLQSPDL GKHLAGVEDL LQLHELVEAD IAVQAERVRA VSASALRFCD
     PGKEYKPCDP QLVSERVASL ERSYEALCKL AAARRARLEE SRRLWRFLWE VGEAEAWVRE
     QQHLLASAET GRDLTGVLRL LNKHTALRGE MSGRLGPLKL TLEQGQQLVA EGHPGAGQAA
     ARTAELQAQW ERLEALAEER AQRLAQAASL YQFQADANDM EAWLVDALRL VSSPELGHDE
     FSTQALARQH RALEEEIRSH RPALDALREQ AAALPPALSH TPEVQGRVPS LERHYEQLQA
     RAGERARALE AALALYTMLS EAGACGLWVE EKEQWLNGLA LPERLEDLEV VQQRFETLEP
     EMNALAARIT AVNDIAEQLL KAKPPSRDSI VDTQKQLNHR WAWGGEPRRA ALTSALSIQN
     YHLECTETQA WMREKTKVIE STQGLGNDLA GVLALQRKLA GTERDLEAIA ARVGELTREA
     NALAAGHPAQ APAINARLGE VQAGWEDLRA TMRRREESLG EARRLQDFLR SLDDFQAWLG
     RTQTSVASEE GPATLPEAEA LLAQHAALRG EVERARGEYS RLRALGEEVT RDQADPQCLF
     LRQRLEALGT GWEELGRMWE SRQGRLAQAH GFQGFLRDAR QAEGVLSSQE YVLSHTEMPG
     TLQAADAAIK NLEDFMSTMD ANGERIRGLL EAGRQLVSAG NIHAEKIQEK ADSIERRHKK
     NQEVVQQLLG RLRDNREQQH FLQDCHELKL WIDEKMLTAQ DVSYDEARNL HTKWQKHQAF
     MAELAANKDW LDKVDKEGRE LTLEKPELKA LVSEKLEDLH KRWDRLESTT QAKARSLFDA
     NRAELFAQSC SALESWLESL QAQLHSDDYG KDLTSVNILL KKQQMAVREK EVEAIQAQAT
     ALAQEDQGAG EVERTSRAVE EKFRALCQPM KERCRRLQAS REQHQFHRDV EDEIVRGPRQ
     SVLFCHRGQT LQKEIQGHEP RIADLTERQR ALGAVAAGPE LAELQEMWKR LSRELELRGK
     RLEAALRAQQ FYRDAAEAEA WMGEQELHMM GQEKAKDELS AQAEVKKHQG LEQALADYAQ
     TVHQLAASIP RCLPRSHSTR ISIRQAQVDK LYASLKELAG ERRERLQEHL RLCQLRRELD
     DLEQWIQERE VVAASHELGQ DYEHVTVSAG WTPAISEKLS QLQARRQETA DKWQEKMDWL
     QLVLEVLVFG RDAGMAEAWL CSQEPLVRSA ELGCTVDEVE SLIKRHEAFQ KSAVAWEERF
     SALEKLTAVR AGGPQECPPS PTAPGLCSPL EEQEKERKRK REEEERRKQP PAPEPTAIRP
     EGDLADGRMA PDAAWDGGFP AVPSWKDGEE GPCRRRVLWD RGGPREESGT GSPWTPEPVT
     RLTYTTVPPR SWQNVYCVLR RGSLGFYKDA KAASTGVPYH GEVPVSLARA QGSVAFDYRK
     RKHVFKLGLQ DGKEYLFQAK DEVSWPLLLP RSHLSAPFSV HSSCRFPSLP SFSLSKCLVP
     PDR
//
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