ID A0A452RJG2_URSAM Unreviewed; 503 AA.
AC A0A452RJG2;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=TBL1X receptor 1 {ECO:0000313|Ensembl:ENSUAMP00000019151.1};
GN Name=TBL1XR1 {ECO:0000313|Ensembl:ENSUAMP00000019151.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000019151.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000019151.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat EBI family.
CC {ECO:0000256|ARBA:ARBA00025741}.
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DR AlphaFoldDB; A0A452RJG2; -.
DR Ensembl; ENSUAMT00000021421.1; ENSUAMP00000019151.1; ENSUAMG00000015061.1.
DR GeneTree; ENSGT00940000153421; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.20.960.30; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045183; Ebi-like.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22846:SF40; F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN TBL1XR1; 1.
DR PANTHER; PTHR22846; WD40 REPEAT PROTEIN; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 4.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 6.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 154..195
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 217..241
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 251..292
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 334..375
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 376..426
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 427..468
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 99..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 503 AA; 54569 MW; 72754B382530A56D CRC64;
MDCDFERLQR SFTSFTFGIE SHISQSNING ALVPPAALIS IIQKGLQYVE AEVSINEDGT
LFDGRPIESL SLIDAVMPDV VQTRQQAYRD KLAQQQAAAA ATSTAATNQQ GSAKNGENTA
NGEENGAHTI ANNHTDMMEV DGDVEIPPNK AVVLRGHESE VFICAWNPVS DLLASGSGDS
TARIWNLSEN STSGSTQLVL RHCIREGGQD VPSNKDVTSL DWNSEGTLLA TGSYDGFARI
WTKDGNLAST LGQHKGPIFA LKWNKKGNFI LSAGVDKTTI IWDAHTGEAK QQFPFHSAPA
LDVDWQSNNT FASCSTDMCI HVCKLGQDRP IKTFQGHTNE VNAIKWDPTG NLLASCSDDM
TLKIWSMKQD SCVHDLQAHN KEIYTIKWSP TGPGTNNPNA NLMLASASFD STVRLWDVDR
GICIHTLTKH QEPVYSVAFS PDGRYLASGS FDKCVHIWNT QTGALVHSYR GTGGIFEVCW
NAAGDKVGAS ASDGSVCVLD LRK
//
