ID A0A452RLT0_URSAM Unreviewed; 762 AA.
AC A0A452RLT0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Seizure related 6 homolog {ECO:0000313|Ensembl:ENSUAMP00000020087.1};
GN Name=SEZ6 {ECO:0000313|Ensembl:ENSUAMP00000020087.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000020087.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000020087.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR AlphaFoldDB; A0A452RLT0; -.
DR Ensembl; ENSUAMT00000022467.1; ENSUAMP00000020087.1; ENSUAMG00000015071.1.
DR GeneTree; ENSGT00940000156995; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 5.
DR CDD; cd00041; CUB; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 5.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR45656; PROTEIN CBR-CLEC-78; 1.
DR PANTHER; PTHR45656:SF1; SEIZURE PROTEIN 6 HOMOLOG; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00084; Sushi; 5.
DR SMART; SM00032; CCP; 5.
DR SMART; SM00042; CUB; 2.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 5.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS50923; SUSHI; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 695..717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 138..197
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 199..312
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 312..373
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 375..486
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 490..549
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 551..614
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 618..679
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DISULFID 199..226
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 520..547
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 762 AA; 83102 MW; B412945AF757D3C4 CRC64;
WAAAPQALEP ASCFLAAVEP GPGRGWLPGT VPPKQTALSP SQVGSNLILT TLSSGHDPPT
PHTKPGFRKV QNISLREGET VTVEGLGGPD PLPLANQSFL LRGQVIRSPT HQAALRFQSL
PPPAGPGTFH FHYQAYLLNC HFPQRPAYGA VTVTSLHPGG SARFRCATGY QLKGARLLTC
LNATQPFWDF QEPVCIAACG GVTRNATTGR IVSPGFPGNY SSNLTCHWLL EAPEGQRLHL
HFEKVSLAED DDRLIIRNGD NVEAPPVYDS YEVEYLPIEG LLSSGRHFFV ELSTDTEAEL
GWAPWFAAFQ QGHCYEPFVK YGNFSSSAPS YPVGTTVEFS CDPGYTLEQG SIIIECIDPH
DPQWNETEPA CRAVCSGEIT DSAGVVLSPN WPEPYSRGQD CIWGVHVEED KRILLDIRVL
RIGPGDVLTF YDGDDLTARV LGQYSGPRGH FKLFTSMADV TIQFQSDPGA SVLGYQQGFV
IHFFEVPRND TCPELPEIPN GWKSPSQPEL VHGTVVTYQC YPGYQVVGSS VLMCQWDLTW
SEDLPSCQRV TSCHDPGDVE HSRRLISSPK FPVGATVQYI CDQGFVLTGS AILTCHDRQA
SSPKWSDRAP KCLLEQLKPC HGLSAPENGA HSPEKRLHPA GATVHFSCAP GYVLKGQASI
KCVPGHPSHW SDPPPICRAV AKAPAASSTL DAAHVAAAIF LPLVVMALLV GGVYLYFSRL
QGKSPLRLPR TRPRPYDRIT VESAFDNPTY EIGETKEYEV SI
//
