ID A0A452RM08_URSAM Unreviewed; 907 AA.
AC A0A452RM08;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Kinesin-like protein {ECO:0000256|RuleBase:RU000394};
GN Name=KIF5B {ECO:0000313|Ensembl:ENSUAMP00000020170.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000020170.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000020170.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283,
CC ECO:0000256|RuleBase:RU000394}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR AlphaFoldDB; A0A452RM08; -.
DR Ensembl; ENSUAMT00000022555.1; ENSUAMP00000020170.1; ENSUAMG00000011679.1.
DR GeneTree; ENSGT00940000154801; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd01369; KISc_KHC_KIF5; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 6.10.250.1590; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 2.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47968; CENTROMERE PROTEIN E; 1.
DR PANTHER; PTHR47968:SF57; KINESIN FAMILY MEMBER 5C; 1.
DR Pfam; PF00225; Kinesin; 2.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000394};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|RuleBase:RU000394};
KW Motor protein {ECO:0000256|RuleBase:RU000394};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000394};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 1..270
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 852..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 275..316
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 363..488
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 907 AA; 102997 MW; 08E6FA6FB4053E9B CRC64;
MADPAECNIK VMCRFRPLNE SEVNRGDKYV AKFQGEDTVM IAVSDPRIKI SYFLIDVLEG
YNGTIFAYGQ TSSGKTHTME ENVADTVHFS FSVSKTNLSV HEDKNRVPYV KGCTERFVCS
PDEVMDTIDE GKSNRHVAVT NMNEHSSRSH SIFLINVKQE NTQTEQKLSG KLYLVDLAGS
EKVSKTGAEG AVLDEAKNIN KSLSALGNVI SALAEGSTYV PYRDSKMTRI LQDSLGGNCR
TTIVICCSPS SYNESETKST LLFGQRAKTI KNTVCVNVEL TAEQWKKKYE REKEKNKTLR
NTIQWLENEL NRWRNGETVP IDEQFDKEKA NLEAFAVDKD ITITNDKPAA TIGVTGNFTD
AERRKCEEEI AKLYKQLDDK DEEINQQSQL VEKLKTQMLD QEELLASTRR DQDNMQAELN
RLQAENDASK EEVKEVLQAL EELAVNYDQK SQEVEDKTKE YELLSDELNQ KSATLASIDA
ELQKLKEMTN HQKKRAAEMM ASLLKDLAEI GIAVGNNDVK PEGTGMIDEE FTVARLYISK
MKSEVKTMVK RCKQLESTQT ESNKKMEENE KELAACQLRI SQHEAKIKSL TEYLQNVEQK
KRQLEESVDS LSEELVQLRA QEKVHEMEKE HLNKVQTANE VKATVEQQIQ SHRETHQKQI
SSLRDEVEAK EKLITDLQDQ NQKMMLEQER LRVEHEKLKA TDQEKSRKLH ELTVMQDRRE
QARQDLKGLE ETVAKELQTL HNLRKLFVQD LATRVKKSAE IDSDDTGGSA AQKQKISFLE
NNLEQLTKVH KQLVRDNADL RCELPKLEKR LRATAERVKA LESALKEAKE NASRDRKRYQ
QEVDRIKEAV RSKNMARRGH SAQIAKPIRP GQHPAASPTH PSAIRGGGAF VQNSQPVAVR
GGGGKQV
//
