ID A0A452RM59_URSAM Unreviewed; 485 AA.
AC A0A452RM59;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=RasGEF domain family member 1A {ECO:0000313|Ensembl:ENSUAMP00000020243.1};
GN Name=RASGEF1A {ECO:0000313|Ensembl:ENSUAMP00000020243.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000020243.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000020243.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A452RM59; -.
DR Ensembl; ENSUAMT00000022639.1; ENSUAMP00000020243.1; ENSUAMG00000015984.1.
DR GeneTree; ENSGT00940000160822; -.
DR OMA; IAKECCE; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF172; RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1A; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 44..174
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 218..465
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 485 AA; 55315 MW; 590A066395A2CE48 CRC64;
MQETMPQTSV IFSSILGPSC SGQVQPGMGE RGSGAGGSGD LVFQEGRLIS GSLEALMEHL
VPTVDYYPDR TYIFTFLLSS RVFIPPHDLL ARVGQICLEQ RQQLETGSEK VKVLMEAPSK
IVQLLKEWTE AFPYDFQDEK AMAELKAITH RVTQCDEENG TVKKAIAQMT QSLLLSLAAR
SQLQELREKL RSPAMDKGSV LKAKPPATQK DILGVCCDPL VLAQQLTHIE LERVNSIHPE
DLMQIVSHMD SRDKHRCRGD LTKTYSLEAY DNWFNCLSML VATEVCRVVK KKHRTRMLEF
FIDVARECFN IGNFNSMMAI ISGMNLSPVA RLKKTWSKVK TAKFDVLEHH MDPSSNFCNY
RTALQGATQR SQMANSSREK IVIPVFNLFV KDIYFLHKIH TNHLPNGHVN FKKFWEISRQ
IHEFMTWTQV ECPFEKDKKI QNYLLTAPIY SEEALFIASF ESEGPENHME KDSWKTLRTT
LLNRA
//
