ID A0A452RNC8_URSAM Unreviewed; 1513 AA.
AC A0A452RNC8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Polybromo 1 {ECO:0000313|Ensembl:ENSUAMP00000020681.1};
GN Name=PBRM1 {ECO:0000313|Ensembl:ENSUAMP00000020681.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000020681.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000020681.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR STRING; 9643.ENSUAMP00000020681; -.
DR Ensembl; ENSUAMT00000023120.1; ENSUAMP00000020681.1; ENSUAMG00000012214.1.
DR GeneTree; ENSGT00390000003017; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0016586; C:RSC-type complex; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR CDD; cd04717; BAH_polybromo; 2.
DR CDD; cd05520; Bromo_polybromo_III; 1.
DR CDD; cd05518; Bromo_polybromo_IV; 1.
DR CDD; cd05515; Bromo_polybromo_V; 1.
DR CDD; cd05526; Bromo_polybromo_VI; 1.
DR CDD; cd21984; HMG-box_PB1; 1.
DR Gene3D; 2.30.30.490; -; 2.
DR Gene3D; 1.20.920.10; Bromodomain-like; 5.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR037968; PBRM1_BD5.
DR InterPro; IPR037382; Rsc/polybromo.
DR PANTHER; PTHR16062:SF19; PROTEIN POLYBROMO-1; 1.
DR PANTHER; PTHR16062; SWI/SNF-RELATED; 1.
DR Pfam; PF01426; BAH; 2.
DR Pfam; PF00439; Bromodomain; 5.
DR Pfam; PF00505; HMG_box; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00439; BAH; 2.
DR SMART; SM00297; BROMO; 5.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47370; Bromodomain; 5.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS51038; BAH; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 3.
DR PROSITE; PS50014; BROMODOMAIN_2; 5.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 25..80
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 209..279
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 362..432
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 500..570
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 641..686
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 780..898
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 980..1096
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 1203..1271
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 1203..1271
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 726..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 930..957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1178..1202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1255..1284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..757
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1513 AA; 172871 MW; CB945C7096C6E3A0 CRC64;
CQCASLFSHY LDTFSYLACL VFVFQQYPDY YAIIKEPIDL KTIAQRIQNG SYKSIHAMAK
DIDLLAKNAK TYNEPGSQVF KDANSIKKIF YMKKAEIEHH EMAKSSLRMR TPSNLATARL
TGPSHSKGSL EERNPTSKYY RNKRTVQGGR LSAITMALQY GSESEEDAAL AAARYEEGES
EAESITSFMD VSNPFYQLYD TVRSCRNNQG QLIAEPFFHL PSKKKYPDYY QQIKMPISLQ
QIRTKLKNQE YETLDHLEGD LNLMFENAKR YNVPSSAIYK RVLKLQQVMQ AKKKELARRD
DIEDGDSMIS SATSDAGSAK RKRNTLDSEM LGLRRLSSKK NIRKQRMKIL FNVVLEAREP
GSGRRLCDLF MVKPSKKDYP DYYKIILEPM DLKIIEHNIR NDKYAGEEGM IEDMKLMFRN
ARHYNEEGSQ VYNDAHILEK LLKDKRKELG PLPDDDDVAS PKLKLSRKSG ISPKKSKYMT
PMQQKLNEVY EAVKNYTDKR GRRLSAIFLR LPSRSELPDY YLTIKKPMDM EKIRSHMMAN
KYQDIDSMVE DFVMMFNNAC TYNEPESLIY KDALVLHKVL LETRRDLEGD EDSHVPNVTL
LIQELIHNLF VSVMSHQDDE GRCYSDSLAE IPAVDPNFPN KPPLTFDIIR KNVENNRYRR
LDLFQEHMFE VLERARRMNR TDSEIYEDAV ELQQFFIKIR DELCKNGEIL LSPALSYTTK
HLHNDVEKEK KEKLPKELEE DKLKREEEKR EAEKSEDSSG AAGLSSLQRT YSQDCSFKNS
MYHVGDYVYV EPAEASLQPH IVCIERLWED SAGEKWLYGC WFYRPNETFH LATRKFLEKE
VFKSDYYNKV PVSKILGKCV VMFVKEYFKL CPENFRDEDV FVCESRYSAK TKSFKKIKLW
TMPISSVRFV PRDVPLPVVR VASVFANADK GDDEKNTDNS EDSRTEDSFN LEKEKEDVPV
EMSNGEPGCH YFEQLRYNDM WLKVGDCVFI KSHGLVRPRV GRIEKVWVRD GAAYFYGPIF
IHPEETEHEP TKMFYKKEVF LSNLEETCPM TCILGKCAVL SFKDFLSCRP TEIPENDILL
CESRYNESDK QMKKFKGLKR FSLSAKVVDD EIYYFRKPIV PQKEPSPLLE KKIQLLEAKF
AELEGGDDDI EEMGEEDSEV IEPPSLPQLQ TPLASELDLM PYTPPQSTPK SAKGSAKKEG
SKRKINMSGY ILFSSEMRAV IKAQHPDYSF GELSRLVGTE WRNLETAKKA EYEERAAKVA
EQQERERAAQ QQQPSASPRA GTPVGALMGV VPPPTPMGML NQQLTPVAGM MGGYPPGLPP
LQGPVDGLVS MGSMQPLHPG GPPPHHLPPG VPGLPGIPPP GVMNQGVAPM VGTPAPGGSP
YGQQVGVLGP PGQQAPPPYP GPHPAAPPVI QQPTTPMFVA PPPKTQRLLH SEAYLKYIEG
LSAESNSISK WDQTLAARRR DVHLSKEQES RLPSHWLKSK GAHTTMADAL WRLRDLMLRD
TLNIRQAYNL ENL
//
