ID A0A452RNP0_URSAM Unreviewed; 222 AA.
AC A0A452RNP0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Neuromodulin {ECO:0000256|ARBA:ARBA00021591, ECO:0000256|RuleBase:RU368113};
DE AltName: Full=Axonal membrane protein GAP-43 {ECO:0000256|ARBA:ARBA00030597, ECO:0000256|RuleBase:RU368113};
DE AltName: Full=Growth-associated protein 43 {ECO:0000256|ARBA:ARBA00033250, ECO:0000256|RuleBase:RU368113};
GN Name=GAP43 {ECO:0000313|Ensembl:ENSUAMP00000020831.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000020831.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000020831.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: This protein is associated with nerve growth. It is a major
CC component of the motile 'growth cones' that form the tips of elongating
CC axons. Plays a role in axonal and dendritic filopodia induction.
CC {ECO:0000256|ARBA:ARBA00025215, ECO:0000256|RuleBase:RU368113}.
CC -!- SUBUNIT: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1,
CC FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with
CC calmodulin. Binds calmodulin with a greater affinity in the absence of
CC Ca(2+) than in its presence. {ECO:0000256|RuleBase:RU368113}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU368113};
CC Peripheral membrane protein {ECO:0000256|RuleBase:RU368113};
CC Cytoplasmic side {ECO:0000256|RuleBase:RU368113}. Cell projection,
CC growth cone membrane {ECO:0000256|ARBA:ARBA00004503,
CC ECO:0000256|RuleBase:RU368113}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004503, ECO:0000256|RuleBase:RU368113};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004503,
CC ECO:0000256|RuleBase:RU368113}. Synapse {ECO:0000256|ARBA:ARBA00034103,
CC ECO:0000256|RuleBase:RU368113}. Cell projection, filopodium membrane
CC {ECO:0000256|ARBA:ARBA00004516, ECO:0000256|RuleBase:RU368113};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004516,
CC ECO:0000256|RuleBase:RU368113}. Perikaryon
CC {ECO:0000256|RuleBase:RU368113}. Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279, ECO:0000256|RuleBase:RU368113}. Cell
CC projection, axon {ECO:0000256|RuleBase:RU368113}. Cytoplasm
CC {ECO:0000256|RuleBase:RU368113}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}. Note=Cytoplasmic surface of growth
CC cone and synaptic plasma membranes. {ECO:0000256|RuleBase:RU368113}.
CC -!- PTM: Palmitoylated. Palmitoylation is essential for plasma membrane
CC association. {ECO:0000256|RuleBase:RU368113}.
CC -!- SIMILARITY: Belongs to the neuromodulin family.
CC {ECO:0000256|ARBA:ARBA00005890, ECO:0000256|RuleBase:RU368113}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A452RNP0; -.
DR STRING; 9643.ENSUAMP00000020831; -.
DR Ensembl; ENSUAMT00000023282.1; ENSUAMP00000020831.1; ENSUAMG00000016404.1.
DR GeneTree; ENSGT00730000111265; -.
DR OMA; PNQTNDK; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0031527; C:filopodium membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032584; C:growth cone membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0051489; P:regulation of filopodium assembly; IEA:Ensembl.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.5.190; -; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001422; Neuromodulin.
DR InterPro; IPR017454; Neuromodulin_C.
DR InterPro; IPR018947; Neuromodulin_gap-junction_N.
DR InterPro; IPR033137; Neuromodulin_P_site.
DR PANTHER; PTHR10699; NEUROMODULIN; 1.
DR PANTHER; PTHR10699:SF15; NEUROMODULIN; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF06614; Neuromodulin; 1.
DR Pfam; PF10580; Neuromodulin_N; 1.
DR PRINTS; PR00215; NEUROMODULIN.
DR SMART; SM00015; IQ; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS00413; NEUROMODULIN_2; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860,
KW ECO:0000256|RuleBase:RU368113};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU368113};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273,
KW ECO:0000256|RuleBase:RU368113}; Cytoplasm {ECO:0000256|RuleBase:RU368113};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU368113};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782,
KW ECO:0000256|RuleBase:RU368113};
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604,
KW ECO:0000256|RuleBase:RU368113};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288, ECO:0000256|RuleBase:RU368113};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902,
KW ECO:0000256|RuleBase:RU368113}; Palmitate {ECO:0000256|RuleBase:RU368113};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU368113};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU368113}.
FT DOMAIN 5..25
FT /note="Neuromodulin gap junction N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10580"
FT DOMAIN 62..222
FT /note="Neuromodulin (GAP-43) C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06614"
FT REGION 1..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..80
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..222
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 222 AA; 22925 MW; EE2D0E9B1B3D9B03 CRC64;
RLCCVEKNDE DQKIEQDGIK PEDKAHKAAT KIQASFRGHI TRKKLKGEKK GDAQAAEAEA
NEKDEAPAAN GVEKKEGEGP TPTDAAPASG PKPEENGKAG ETPSEEKKGE GAPAPSEEKA
GSAETESATK ASTDNSPSSK AEDAPAKEEP KPADVPAAVT AAAATPPAAE DAAAKATAQP
PTDAAESSQA EEKIAVDETK PKESARQDEG KGEEREADQE HA
//
