ID A0A452RP25_URSAM Unreviewed; 352 AA.
AC A0A452RP25;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Chromobox 8 {ECO:0000313|Ensembl:ENSUAMP00000020993.1};
GN Name=CBX8 {ECO:0000313|Ensembl:ENSUAMP00000020993.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000020993.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000020993.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A452RP25; -.
DR STRING; 9643.ENSUAMP00000020993; -.
DR Ensembl; ENSUAMT00000023450.1; ENSUAMP00000020993.1; ENSUAMG00000016512.1.
DR GeneTree; ENSGT00940000158476; -.
DR OMA; HPENHGH; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0035102; C:PRC1 complex; IEA:Ensembl.
DR GO; GO:0035064; F:methylated histone binding; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd18627; CD_polycomb_like; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR InterPro; IPR033773; CBX7_C.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR023779; Chromodomain_CS.
DR PANTHER; PTHR46389:SF1; CHROMOBOX PROTEIN HOMOLOG 8; 1.
DR PANTHER; PTHR46389; POLYCOMB GROUP PROTEIN PC; 1.
DR Pfam; PF17218; CBX7_C; 1.
DR Pfam; PF00385; Chromo; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR PROSITE; PS00598; CHROMO_1; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 1..44
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REGION 66..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 352 AA; 38930 MW; B547B6E1617DB8CD CRC64;
MEYLVKWKGW SQKYSTWEPE ENILDARLLA AFEEREREME LYGPKKRGPK PKTFLLKAQA
KAKAKTYEFR SDSARGIRIP YPGRSPQDLA STSRAREGLR NMGLSPPGSS SSTSSTCRVE
PPRDRDRERE RERERERERE RERGASRTDD KPSSPGDSSK KRGPKPRKEL LDPSQRPLGE
ASDGLGDYLK GRKLDEAPSG AGKFPAGHSV IQLARRQDSD LAQCGVASPS PAEATGKLAM
DTFPARVIKH RATFLEARGQ GTLDPGGPRV RHGSGTPGSV GGLYRDMGAQ GGRPSLIARI
PVARILGDPE EESWSPSLTN LEKVVVTDVT SNFLTVTIKE SNTDQGFFKE KR
//
