ID A0A452RP60_URSAM Unreviewed; 570 AA.
AC A0A452RP60;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=FERM domain containing 1 {ECO:0000313|Ensembl:ENSUAMP00000021037.1};
GN Name=FRMD1 {ECO:0000313|Ensembl:ENSUAMP00000021037.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000021037.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000021037.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A452RP60; -.
DR STRING; 9643.ENSUAMP00000021037; -.
DR Ensembl; ENSUAMT00000023496.1; ENSUAMP00000021037.1; ENSUAMG00000016544.1.
DR GeneTree; ENSGT00940000162787; -.
DR OMA; SYGCVYS; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13185; FERM_C_FRMD1_FRMD6; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR041781; FRMD6-FERM_C.
DR InterPro; IPR047145; FRMD6-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR13429; FERM DOMAIN (PROTEIN4.1-EZRIN-RADIXIN-MOESIN) FAMILY; 1.
DR PANTHER; PTHR13429:SF7; FERM DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 58..363
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 1..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 570 AA; 63555 MW; A0BC34664A299579 CRC64;
MENTAHPRPW ASPHGPGQRQ QAPHTRGLSP PGWVGGPPVS SLGRHQGAWV GSSGGPPAPL
RLRTPSPGPE PPHVLQVQAT GRELFQQVCD MASIRDAHFF GLSVVRNNEY MFMDLEQKLS
KYFSKDWKRE GHKDSGRPRA PFVTFLRVQF YVENGRLLRD RTARHLYYCH LKERVLRSQC
AHREEAYFLL AAYGLQADLG NHREPVHVGR YFEPHAYFPP WIIARRGSAY ILRHAPAMHR
EQRGLNPTEA VLRFIREACR LEDVPVHFFR LYKDKKDDRP TVILGLTLNG MQIYQETSHA
PELLYDFPWS HVGKVVFLGK KFEVWPDGLP SARKLVFYTG CAWRSRHLLR LLGASHQLRL
VLQPALRRLQ QREEAEEKKH YRESYISDTL DLDLDLDPGG RGSPGSPHSG GSRDSGGSSQ
HLHHRLSVRS ADSHSSSHTS GIEADVRPLE PGEMSVDVPL GAEAPRAEAP PCSSSTSQSS
HCTDGGSGDR PEGDTKGWAD ASGPGPTAVV QVPLTGVRGR SAKALHQMPE ADPQHRSPDH
ALPGTHAVRS TNSLLLVLCK DDQLPQEFVV
//
