ID   A0A452RS30_URSAM        Unreviewed;       260 AA.
AC   A0A452RS30;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Transmembrane protein 184C {ECO:0000256|ARBA:ARBA00040417};
DE   AltName: Full=Transmembrane protein 34 {ECO:0000256|ARBA:ARBA00042686};
GN   Name=TMEM184C {ECO:0000313|Ensembl:ENSUAMP00000022127.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000022127.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000022127.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Possible tumor suppressor which may play a role in cell
CC       growth. {ECO:0000256|ARBA:ARBA00037365}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the TMEM184 family.
CC       {ECO:0000256|ARBA:ARBA00038513}.
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DR   AlphaFoldDB; A0A452RS30; -.
DR   STRING; 9643.ENSUAMP00000022127; -.
DR   Ensembl; ENSUAMT00000024739.1; ENSUAMP00000022127.1; ENSUAMG00000017411.1.
DR   GeneTree; ENSGT00940000155201; -.
DR   OMA; MITLQYF; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR005178; Ostalpha/TMEM184C.
DR   PANTHER; PTHR23423; ORGANIC SOLUTE TRANSPORTER-RELATED; 1.
DR   PANTHER; PTHR23423:SF10; TRANSMEMBRANE PROTEIN 184C; 1.
DR   Pfam; PF03619; Solute_trans_a; 1.
DR   SMART; SM01417; Solute_trans_a; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        49..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        181..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        211..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   260 AA;  30454 MW;  E006DDEF0B0E4D4A CRC64;
     MPCTCTWRNW RQWIRPLAVV IYLVSIVVAV PLCVWELQKL EVGIHTKAWF IAGIFLLLTI
     PISLWVILQH LVHYTQPELQ KPIIRILWMV PIYSLDSWIA LKYPSIAIYV DTCRECYEAY
     VIYNFMGFLT NYLTNRYPNL VLILEAKDQQ KHFPPLCCCP PWTMGEVLLF RCKLGVLQYT
     VVRPFTTIVA LICELLGIYD EGNFSFSNAW TYLVIINNMS QLFAMYCLLL FYKVLKEELS
     PIQPVGKFLC VKLVVFVSFW
//