ID A0A452RSK1_URSAM Unreviewed; 1007 AA.
AC A0A452RSK1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Pleckstrin homology domain containing A5 {ECO:0000313|Ensembl:ENSUAMP00000022313.1};
GN Name=PLEKHA5 {ECO:0000313|Ensembl:ENSUAMP00000022313.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000022313.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000022313.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 9643.ENSUAMP00000022313; -.
DR Ensembl; ENSUAMT00000024945.1; ENSUAMP00000022313.1; ENSUAMG00000017549.1.
DR Ensembl; ENSUAMT00000024946.1; ENSUAMP00000022314.1; ENSUAMG00000017549.1.
DR GeneTree; ENSGT00940000155728; -.
DR OMA; AXTESAG; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR CDD; cd13248; PH_PEPP1_2_3; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR040392; PKHA4-7_PH.
DR PANTHER; PTHR12752; PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN; 1.
DR PANTHER; PTHR12752:SF3; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 5; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 61..160
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 31..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 709..753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 838..898
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 909..928
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..955
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 959..1001
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1007 AA; 114891 MW; 8DF55A7E75C7EAD7 CRC64;
MTSEEKKERP ISMINEASNY NMTSDYAAHP MSPVGRTSRA SKKVHNFGKR SNSIKRNPNA
PVVRRGWLYK QDSTGMKLWK KRWFVLSDLC LFYYRDEKEE GILGSILLPS FQIAMLTSED
HINRKYAFKA AHPNMRTYYF CTDTGKEMEL WMKAMLDAAL VQTEPVKRVD KITSENAPAK
EINNFPNHRV LIKPEVQNNQ KNKEISKNEE KKALEAEKYG FQKDGQDRPL TKINSVKLNS
LPSEYEIGST CPAQTGHYRP VNVNSSENKT VNVSLADLRG GNHPNTGPLH TEADRVIQRT
NSMQQLEQWI KIQKGRGHEE ETRGVISYQT LPRNMPSHRA QVMARYPEGY RTLPRNSKTR
PESICSVTPS SHDRTVGPGA EEKRRSMRDD TMWQLYEWQQ RQFYNKQSTL PRHGTLTSPK
TMVNISDQTM HSIPTSPSHG SIAAYQGYSP QRTYRSEVSS PIQRGDVTID RRHRVHHPKH
VYVPDRRSMP AGLTLQSISP QSLQGKTLSQ DECRGTLYKY RPEEVDIDAK LSRLCEQDKV
VHALEEKLQQ LHKEKYTLEQ ALLSASQEIE MNADNPAAIQ TVVLQRDDLQ NGLLSTCREL
SRATAELERA WREYDKLEYD VTVTRNQMQE QLDRLGEVQT ESAGIQRAQI QKELWRIQDV
MEGLSKHKQQ RGTTETGMAG SKPFSAVKYK NEGPDYRLYK SEPELTTVAE VDESNGEEKS
EPVSEMETSV KGPHFPVGVV PPRTKSPTPE SSTIASYVTL RKTKKMMDSR TERPRSAVEQ
LCLAESTRPR MTVEEQMERI RRHQQACLRE KKKGLNVIGA LDQSPLQSPS GLRDNPFRIT
QTRRRDENIK ESDAVIREHD VKPNHETPAA EIVRLKEVEP QNTDFSKELE KTEDIFSKTP
SKPEPNGVSS EEVMDKEANK EKVPEDVSYS PQDETQITNH KAESHPEENI KDNILEQEET
IVSYEQTPEA SRGNQTTAVK SLSPSPESSP VPATQPQLTE GSHFMCV
//
