ID A0A452RV69_URSAM Unreviewed; 519 AA.
AC A0A452RV69;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Rho guanine nucleotide exchange factor 3 {ECO:0000256|ARBA:ARBA00023847};
GN Name=ARHGEF3 {ECO:0000313|Ensembl:ENSUAMP00000023335.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000023335.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000023335.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for RhoA
CC and RhoB GTPases. {ECO:0000256|ARBA:ARBA00043905}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; A0A452RV69; -.
DR Ensembl; ENSUAMT00000026068.1; ENSUAMP00000023335.1; ENSUAMG00000018291.1.
DR GeneTree; ENSGT00940000158385; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd10572; PH_RhoGEF3_XPLN; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR044129; PH_RhoGEF3_XPLN.
DR PANTHER; PTHR46006:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291022}.
FT DOMAIN 115..297
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 284..442
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 456..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 519 AA; 58969 MW; 3B3E9F47112710CE CRC64;
ASLAFSIKIC CLHVLSSKGN CPLCLCKINK RVKPLSRVTS LANLIPPVKA TPLKRFSQTL
QRSISFRSES RPDILAPRPW SRNAAPSSTK RRDSKLWSET FDVCVNQMLP SKEIKRQEAI
FELSQGEEDL IEDLKLAKKA YHDPMLKLSI MTEQELNQIF GTLDSLIPLH EELLSQLRDA
RKPDGSTEHV GPILVGWLPC LSSYDSYCSN QVAAKALLDH KKQDHRVQDF LQRCLESPFS
RKLDLWNFLD IPRSRLVKYP LLLREILRHT PNDNPDQQHL EEAINIIQGI VAEINTKTGE
SECRYYKERL LYLEEGQKDS LIDNSRVLCC HGELKNNRGV KLHVFLFQEV LVITRAVTHN
EQLCYQLYRQ PIPVKDLLLE DLQDGEVRLG GSLRGAFSNN ERIKNFFRVS FKNGSQSQTH
SLQANDTFNK QQWLNCIRQA KETVLCAAGQ AGVLDSEGPF LNPTTGSQEP QGETKLEQMD
QSDSESDCSM DTSEVSLDCE RMEQTDSSCG NSRHIESNV
//
