ID   A0A452RW54_URSAM        Unreviewed;       348 AA.
AC   A0A452RW54;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Heparan sulfate 2-O-sulfotransferase 1 {ECO:0000256|ARBA:ARBA00039773};
GN   Name=HS2ST1 {ECO:0000313|Ensembl:ENSUAMP00000023713.1};
OS   Ursus americanus (American black bear) (Euarctos americanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000023713.1, ECO:0000313|Proteomes:UP000291022};
RN   [1] {ECO:0000313|Proteomes:UP000291022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA   Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT   "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT   in black bear kidneys.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSUAMP00000023713.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC       pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC   -!- SIMILARITY: Belongs to the sulfotransferase 3 family.
CC       {ECO:0000256|ARBA:ARBA00010569}.
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DR   AlphaFoldDB; A0A452RW54; -.
DR   STRING; 9643.ENSUAMP00000023713; -.
DR   Ensembl; ENSUAMT00000026483.1; ENSUAMP00000023713.1; ENSUAMG00000018570.1.
DR   GeneTree; ENSGT00530000063408; -.
DR   OMA; NITANMH; -.
DR   Proteomes; UP000291022; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR007734; Heparan_SO4_2-O-STrfase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005331; Sulfotransferase.
DR   PANTHER; PTHR12129; HEPARAN SULFATE 2-O-SULFOTRANSFERASE; 1.
DR   PANTHER; PTHR12129:SF17; HEPARAN SULFATE 2-O-SULFOTRANSFERASE 1; 1.
DR   Pfam; PF03567; Sulfotransfer_2; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..348
FT                   /note="Heparan sulfate 2-O-sulfotransferase 1"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5019042392"
SQ   SEQUENCE   348 AA;  40889 MW;  D2E6B77F46435AA3 CRC64;
     LSAPRGVCFS LSLCLLLFLL MLSLLSSQLF FFSERAIARH EVREIEQRHT MDGPRQEAVL
     DEEEDMVIIY NRVPKTASTS FTNIAYDLCA KNKYHVLHIN TTKNNPVMSL QDQVRFVKNI
     TSWKEMKPGF YHGHVSYLDF AKFGVKKKPI YINVIRDPIE RLVSYYYFLR FGDDYRPGLR
     RRKQGDKKTF DECVAEGGSD CAPEKLWLQI PFFCGHSSEC WNVGSRWAMD QAKYNLINEY
     FLVGVTEELE DFIMLLEAAL PRFFRGATEL YRTGKKSHLR KTTEKKLPTK QTIAKLQQSD
     IWKMENEFYE FALEQFQFIR AHAVREKDGD LYILAQNFFY EKIYPKSN
//