ID A0A452RXT0_URSAM Unreviewed; 2467 AA.
AC A0A452RXT0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Spectrin alpha, non-erythrocytic 1 {ECO:0000313|Ensembl:ENSUAMP00000024446.1};
GN Name=SPTAN1 {ECO:0000313|Ensembl:ENSUAMP00000024446.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000024446.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000024446.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826}.
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DR Ensembl; ENSUAMT00000027298.1; ENSUAMP00000024446.1; ENSUAMG00000006711.1.
DR GeneTree; ENSGT00940000156662; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR CDD; cd00051; EFh; 1.
DR CDD; cd11808; SH3_Alpha_Spectrin; 1.
DR CDD; cd00176; SPEC; 12.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.60; -; 20.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035825; Alpha_Spectrin_SH3.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014837; EF-hand_Ca_insen.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF435; SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 5; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF08726; EFhand_Ca_insen; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF00435; Spectrin; 20.
DR PRINTS; PR00452; SH3DOMAIN.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00054; EFh; 2.
DR SMART; SM01184; efhand_Ca_insen; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00150; SPEC; 20.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 16.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 967..1026
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 2318..2353
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 2361..2396
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT COILED 290..324
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 386..416
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 858..889
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1126..1160
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1687..1721
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2166..2198
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2467 AA; 283365 MW; D08BC6ED80EAC834 CRC64;
MDPSGVKVLE TAEDIQERRQ QVLDRYHRFK ELSTLRRQKL EDSYRFQFFQ RDAEELEKWI
QEKLQIASDE NYKDPTNLQG KLQKHQAFEA EVQANSGAIV KLDETGNLMI SEGHFASETI
RTRLMELHRQ WELLLEKMRE KGVKLLQAQK LVQYLRECED VMDWINDKEA IVTSEELGQD
LEHVEVLQKK FEEFQTDMAA HEERVNEVNQ FAAKLIQEQH PEEDTIKTKQ DEVNAAWQRL
KGLALQRQGK LFGAAEVQRF NRDVDETISW IKEKEQLMAS DDFGRDLASV QALLRKHEGL
ERDLAALEDK VKALCAEADR LQQSHPLSAA QIQVKREELI ANWEQIRTLA AERHARLNDS
YRLQRFLADF RDLTSWVTEM KALINADELA NDVAGAEALL DRHQEHKGEI DAHEDSFKSA
DESGQALLAA GHYASDEVRE KLSVLAEERA ALLELWELRR QQYEQCMDLQ LFYRDTEQVD
NWMSKQEAFL LNEDLGDSLD SVEALLKKHE DFEKSLSAQE EKITALDEFA TKLIQNNHYA
MDDVATRRDA LLSRRNALHE RAMGRRAQLA DSFHLQQFFR DSDELKSWVN EKMKTATDEA
YKDPSNLQGK VQKHQAFEAE LSANQSRIDA LEKAGQKLID VNHYAKDEVA ARMNEVISLW
KKLLEATELK GIKLREANQQ QQFNRNVEDI ELWLYEVEGH LASDDYGKDL TNVQNLQKKH
ALLEADVAAH QDRIDGITIQ ARQFQDAGHF DAENIKKKQE ALVARYEALK EPMIARKQKL
ADSLRLQQLF RDVEDEETWI REKEPIAAST NRGKDLIGVQ NLLKKHQALQ AEIAGHEPRI
KAVTQKGNAM VEEGHFAAED VKAKLSELNQ KWESLKSKAS QRRQDLEDSL QAQQYFADAN
EAESWMREKE PIVGSTDYGK DEDSAEALLK KHEALMSDLS AYGSSIQALR DQAQSCRQQV
APMDDETGKE LVLALYDYQE KSPREVTMKK GDILTLLNST NKDWWKVEVN DRQGFVPAAY
VKKLDPAQSA SRENLLEEQG SIAVRQEQID HQTRVTKEAG SVSLRMKQVE ELYHSLLELG
EKRKGMLEKS CKRFMLFREA NELQQWINEK EAALTSEEVG ADLEQVEVLQ KKFDDFQKDL
KANESRLKDI NKVAEDLESE GLMAEEVQAV QQQVSSWGSR GGPDSKTASP WKVGLTAVLP
QELNERWRSL QQLAEERSQL LGSAHEVQRF HRDADETKEW IEEKNQALNT DNYGHDLASV
QALQRKHEGF ERDLAALGDK VNSLGETAER LIQSHPESAE DLQEKCTELD QAWGSLGKRA
DQRKAKLGDS HDLQRFLSDF RDLMSWINGI RGLVSSDELA KDVTGAEALL ERHQEHRTEI
DARAGTFQAF EQFGQQLLAH GHYASPEVKE KLDILDRERA GLEKAWAQRR MMLDQCLELQ
LFHRDCEQAE NWMAAREAFL NTEDKGDSLD SVEALIKKHE DFDKAINVQE EKIAALQSFA
DQLVAAGHYA KGDICSRRNE VLDRWVWRRL KAQMIEKRSK LGESQTLQQF SRDVDEIEAW
ISEKLQTASD ESYKDPTNIQ SKHQKHQAFE AELHANADRI RGVIDTGNSL IERGACAGSE
DAVKARLAAL ADQWQFLVQK SAEKSQKLKE ANKQQNFNTG IKDFDFWLSE VEALLASEDY
GKDLASVNNL LKKHQLLEAD ISAHEDRLKD LNSQADSLMT SSAFDTSQVK DKRDTINGRF
QKIKTMAASR RAKLNESHRL HQFFRDMDDE ESWIKEKKLL VSSEDYGRDL TGVQNLRKKH
KRLEAELAAH EPAIQGVLDT GKKLSDDNTI GKEEIQQRLA QFVEHWKELK QLATARGQRL
EESLEYQQFV ANVEEEEAWI NEKMTLVASE DYGDTLAAIQ GLLKKHEAFE TDFTVHKDRV
NDVCSNGQDL IKKNNHHEEN ISSKMKGLNG KVSDLEKAAA QRKAKLEENS AFLQFNWKAD
VVESWIGEKE NSLKTDDYGR DLSSVQTLLT KQETFDAGLQ AFQQEGIANI TALKDQLLAA
KHIQSKAIEA RHASLMKRWS QLLANSATRK KKLLEAQSHF RKVEDLFLTF AKKASAFNSW
FENAEEDLTD PVRCNSLEEI RALREAHDAF RSSLSSAQAD FSQLAELDRQ IKSFRVASNP
YTWFTMEALE ETWRNLQKII KERELELQKE QRRQEENDKL RQEFAQHANA FHQWIQETRC
PPAPGASCMV EESGTLESQL EATKRKHQEI RAMRSQLKKI EDLGAAMEEA LILDNKYTEH
STVGLAQQWD QLDQLGMRMQ HNLEQQIQAR NTTGVTEEAL KEFSMMFKHF DKDKSGRLNH
QEFKSCLRSL GYDLPMVEEG EPDPEFEAIL DTVDPNRDGH VSLQEYMAFM ISRETENVKS
SEEIESAFRA LSSEGKPYVT KEELYQNLTR EQADYCVSHM KPYVDGKGRE LPTAFDYVEF
TRSLFVN
//