ID A0A452RYG7_URSAM Unreviewed; 1262 AA.
AC A0A452RYG7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=LDL receptor related protein 2 {ECO:0000313|Ensembl:ENSUAMP00000024691.1};
GN Name=LRP2 {ECO:0000313|Ensembl:ENSUAMP00000024691.1};
OS Ursus americanus (American black bear) (Euarctos americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX NCBI_TaxID=9643 {ECO:0000313|Ensembl:ENSUAMP00000024691.1, ECO:0000313|Proteomes:UP000291022};
RN [1] {ECO:0000313|Proteomes:UP000291022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Korstanje R., Srivastava A., Sarsani V.K., Sheehan S.M., Seger R.L.,
RA Barter M.E., Lindqvist C., Brody L.C., Mullikin J.C.;
RT "De novo assembly and RNA-Seq shows season-dependent expression and editing
RT in black bear kidneys.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSUAMP00000024691.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR AlphaFoldDB; A0A452RYG7; -.
DR Ensembl; ENSUAMT00000027565.1; ENSUAMP00000024691.1; ENSUAMG00000019021.1.
DR GeneTree; ENSGT00940000157232; -.
DR OMA; GKTVIHG; -.
DR Proteomes; UP000291022; Unassembled WGS sequence.
DR GO; GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 15.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 15.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 3.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722:SF11; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2; 1.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR Pfam; PF00057; Ldl_recept_a; 14.
DR Pfam; PF00058; Ldl_recept_b; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 15.
DR SMART; SM00135; LY; 7.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 15.
DR SUPFAM; SSF63825; YWTD domain; 2.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS01209; LDLRA_1; 7.
DR PROSITE; PS50068; LDLRA_2; 15.
DR PROSITE; PS51120; LDLRB; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000291022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 58..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 424..438
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REPEAT 530..572
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 657..672
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REPEAT 696..737
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 738..781
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 782..825
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 88..106
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 100..115
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 161..173
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 168..186
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 180..195
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 205..223
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 217..232
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 236..248
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 243..261
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 255..270
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 275..287
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 282..300
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 294..309
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 926..938
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 933..951
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 945..960
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 967..979
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 974..992
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 986..1001
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1009..1021
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1016..1034
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1028..1043
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1049..1061
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1056..1074
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1068..1083
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1107..1122
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1171..1183
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1178..1196
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1190..1205
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1262 AA; 141080 MW; 6AB338BC74D1A972 CRC64;
MWIATLEKSH VFPFILELGE IFLFLSLFAS SLSFFGVREH RAVVKITQIL ELELSGPNLC
FAHVCCLILG KLLNCFVPQV LCFEQFRCED GQCISASWRC DGTRDCLDDS DEVGCPSPSC
KSDQFLCQGE SLCIPNFWEC DGDLDCEDGS DEHQHCPGRT CSSHQITCSN GECIPNEYRC
DHVRDCSDGT DEKDCQYPTC EQLTCANGAC YNSSQKCDGK VDCRDFSDEN NCTKVCLQHE
FQCDGGVCLP HAYVCDHYPD CEDGSDEHSC TYETCRGNQF TCHSGYCISQ NSVCDGENDC
KDNSDENGCE SSSHHIRECY PGEWACPESG KCIPIGNVCD GTIDCPGGED ENNSTKGRYC
DVNLCSLLSC EYQCRMSPNG GMCYCPPGFI VDQNNTRNCV DFNDCQIWGV CDQICEDRVG
HHQCHCAEGY VLEHQRHCKA NTSSEQASVI FSNGRDLLIG DIHGRTFAML VQSQNHGVAV
GVDFHYHLHR VFWTDTVQDK VFSVDIDGLN IQEVVSLDDP ENVAVDWVNN KLYLVETKVN
RIDMVNLDGS HRVILITGNL GHPRGIALDP TVGKTVVQGD HVFFTDWTKM AVMKANKFTE
PSPQEYHQTS LRPFGVTVYH SLRQPYVSNP CRDNNGGCEH VCVLSHRTDN DGLGYRCRCT
LGFSLDVDNR HCVGREILTA NRVESVESLT FDWISKNLYW TDASYRSVSV MRLADKSRRA
IIQKLNNPRS IVVHPIAGYI FFTDWFRPAK IMRAWSDGSN LLPIVNTTLG WPNGLAIDWG
ALRLYWVDAF FDKIEHSTFD GLDRRNLGHI QQMTHPFGLT VFEDHVFFTD WRLGAIVRVR
KTDGGDMRVI RSGITNIMHV KSYDANTQTG SNYCNRPTHP NGDCSHFCFP VPNFQRVCGC
PYGMSLTSNH LTCQEDPSRE PPMQQCGSFS FPCSNGRCVP SNYRCDGVDD CHDNSDEHLC
GKFNNTCAPS AFTCGHGECI PAHWKCDKQY DCVDGSDEQN CPSQAPTSCP ASFFTCDNHM
CIPRSWLCDT DNDCADGSDE KNCQFTETCL PSQFRCPDHR CIDLSFVCDG DKDCVDGSDE
AGCVINCTAF QFKCASEDRC ISNIYHCDGV SDCSDHSDEI DCSTRPPGMC HPDEFQCQAD
GVCIPKSWEC DGHSDCVFGS DEHRGCAPRT CPPSRFLCDN GNCIHRDWLC DGDNDCRDMS
DEKDCPTQAF HCPSWQWHCP GYSICVNLSA VCDGIFDCPN GTDESPLCSK FPDHSLMAIN
SL
//
